Impact of vitamin D supplementation on C-reactive protein; a systematic review and meta-analysis of randomized controlled trials

Mazidi, Mohsen; Rezaie, Peyman; Vatanparast, Hassan

doi:10.1186/s40795-017-0207-6

Cited by 51 publications

(44 citation statements)

References 48 publications

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“…In Ethiopia, a high national prevalence of Zn deficiency has been estimated previously based on Zn supplies in the food system, which reported that 81% of the population were at risk of deficiency due to inadequate dietary Zn supplies, estimated from food balance sheets and regional food composition data 11 . A high prevalence of Zn deficiency (> 20%) has also been reported based on serum Zn status and dietary Zn intake among young children and school-aged children 13 , 34 – 36 and women and pregnant women 12 , 37 , 38 . Several factors may contribute to a high prevalence of Zn deficiency in Ethiopia, where the consumption of Zn-rich foods such as meat is low 39 .…”

Section: Discussionmentioning

confidence: 96%

“…This high prevalence of Zn deficiency is consistent with reports of low dietary Zn intake. For example, Girmay et al reported that the mean dietary Zn intake among children 6–35 months (n = 6,752) was 1.74 mg day −1 at national level 13 , which is small compared to an Estimated Average Requirement (EAR) of 2.5 mg day −1 . Furthermore, the phytate contents of Ethiopian diets are high which is likely to inhibit Zn absorption 5 .…”

Section: Introductionmentioning

confidence: 99%

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Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia

Belay

Gashu

Joy

et al. 2021

Sci Rep

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Zinc (Zn) is an essential nutrient for human health. In Ethiopia, a high prevalence of Zn deficiency has been reported. To explore demographic variation and spatial dependencies in the Zn status of the Ethiopian population, we analyzed archived serum samples (n = 3373) from the 2015 Ethiopian National Micronutrient Survey (ENMS), a cross-sectional survey of young children, school-age children, women of reproductive age (WRA) and men conducted in all 9 regions and two city administration of Ethiopia. Serum Zn concentrations, measured using inductively coupled plasma-mass spectrometry (ICPMS), were compared to thresholds based on age, sex, fasting status, and time of blood collection, after adjusting for inflammation status. Median serum Zn concentration of the population was 57.5 μg dL−1. Overall, it is estimated that 72% of the population was Zn deficient, with high prevalence in all demographic groups. Spatial statistical analysis showed that there was spatial dependence in Zn status of WRA at distances of up to 45 km. Zinc deficiency is spatially dependent over short distances. Although WRA in most areas are likely to be Zn deficient, prevalence of deficiency varies at regional scale and between rural and urban inhabitants, suggesting there is scope to explore drivers of this variation, prioritize nutritional interventions, and to design more representative surveillance programs.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia

Belay

Gashu

Joy

et al. 2021

Sci Rep

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“…It is suggested that PTH may cause insulin resistance by reducing glucose uptake by the liver, muscle, and adipose cells [51]. A recent study revealed that vitamin D supplementation has no effect on CRP, interleukin-10, or tumor necrosis factor-α concentrations [52].…”

Section: Discussionmentioning

confidence: 99%

Effects of vitamin D supplementation on insulin resistance and dyslipidemia in overweight and obese premenopausal women

Imga¹,

Karci²,

Öztaş

et al. 2019

aoms

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Introduction Vitamin D deficiency is a common problem, and it is related to increased risk of obesity, metabolic syndrome, atherosclerosis, and cardiovascular disease. Vitamin D has a beneficial effect on dyslipidemia and insulin secretion. We aimed to investigate the impact of vitamin D 3 supplementation on anthropometric and laboratory parameters in overweight and obese premenopausal women. Material and methods Seventy-two overweight and 50 obese vitamin-D-deficient premenopausal women (mean age: 43.1 ±10.4 years) were included in the study. Baseline mean 25-hydroxyvitamin D [25(OH)D] level was 6.1 (min.–max. = 2.9–15.8) ng/ml in overweight and was 5.6 (min.–max. = 3.0–22.0) ng/ml in obese subjects. At baseline and at the sixth month of supplementation, serum 25(OH)D, intact parathormone (iPTH), calcium, phosphorus, homeostasis model assessment of insulin resistance (HOMA-IR), and lipid profiles were assessed. Results Following vitamin D 3 supplementation in overweight and obese subjects, serum 25(OH)D increased from 6.1 to 34.7 ng/ml and 5.6 to 34.7 ng/ml, respectively ( p < 0.001). At the sixth month of supplementation in both overweight and obese subjects, a significant reduction was detected in HOMA-IR ( p < 0.001), low-density lipoprotein cholesterol (LDL-C) ( p = 0.046, p = 0.044; respectively) and iPTH levels ( p ≤ 0.001, p < 0.001; respectively). A negative adjusted correlation was found between changes in 25(OH)D and HOMA-IR ( r = –0.581, p < 0.001; r = –0.389, p = 0.005; respectively). A 1 ng/ml increase in serum 25(OH)D level led to a 0.30-fold reduction in HOMA-IR level ( p = 0.002). Conclusions Our results support the effect of vitamin D 3 supplementation in HOMA-IR and LDL-C improvement in both obese and overweight subjects. Further studies focused on low serum 25(OH)D levels with insulin resistance and dyslipidemia are needed.

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“…This study correlated the low serum level of vitamin D with a higher C-reactive protein (CRP) level in COVID-19 patients based on previous findings (85,86). In fact, multiple observational and intervention studies have suggested the beneficial effects of vitamin D on reducing circulating CRP and pro-inflammatory cytokines (86)(87)(88)(89)(90). This has a beneficial impact in lowering a heightened inflammation state that is associated with poorer outcomes (91)(92)(93).…”

Section: Vitamin D Prevents the Maladaptive Cycle Of Local Inflammatimentioning

confidence: 90%

Vitamin D Supplementation Could Potentially Reduce Risk of COVID-19 Infections and Deaths

Tay

Mahajan

Thornton

2020

Preprint

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Vitamin D has long been known to be a major regulator for both the endocrine and the immune system. With the advent of COVID-19 pandemic, there has been a growing interest in looking at the feasibility of using vitamin D as a preventative and therapeutic option in the management of the disease. A low serum level of vitamin D is linked to higher incidence of respiratory tract infection and disease progression. Vitamin D supplementation has proven to be effective in enhancing the immune system, strengthen lung epithelial barrier, and prevention of unchecked inflammatory response. Previous studies on the roles of vitamin D in managing influenza and other enveloped virus infection could shed light on the possible roles of vitamin D in the current pandemic. More randomised controlled trials are needed to explore the effects of vitamin D supplementation on COVID-19 infection. Review Criteria: Papers published in the MEDLINE and EMBASE databases were reviewed for evidence relating viral and respiratory tract infections to vitamin D deficiency; the effects of vitamin D supplementation on the immune and inflammatory responses; and ongoing trials on the use of vitamin D in managing COVID-19 illness. The findings were discussed and dose recommendation for vitamin D supplements summarised. Message for the Clinic: Vitamin D could be a readily accessible and cost-effective adjuvant therapy for COVID-19 that deserves further research.

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Impact of vitamin D supplementation on C-reactive protein; a systematic review and meta-analysis of randomized controlled trials

Cited by 51 publications

References 48 publications

Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia

Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia

Effects of vitamin D supplementation on insulin resistance and dyslipidemia in overweight and obese premenopausal women

Vitamin D Supplementation Could Potentially Reduce Risk of COVID-19 Infections and Deaths

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