The feasibility and efficiency of the degradation of volatile organic compounds (VOCs) by non-thermal plasmas(NTP) has been extensive investigated and proved in laboratory experiments with single target component. In practical, multicomponent VOCs are emitted during industrial production. It is urgent need to study the abatement of multicomponent VOCs to evaluate the effectiveness of NTP technology in application, and explore the impact of interactions between VOCs components on degradation efficiency. This study focused on the degradation of VOCs mixtures composed of toluene (TOL), acetone (AC), and ethyl acetate (EA) by dielectric barrier discharge (DBD) plasma in room temperature. Through changing the target gas in turn and the concentration ratio of additive gas in binary mixture, the influence of the composition and the concentration ratio of the additive gases on the target gas degradation have been investigated by comparing the decomposition of the single compound. The results showed that AC and EA had little or no inhibitory effect on degradation of TOL. When AC was added and degraded together with TOL, the degradation rate of TOL remained almost unchanged with slight fluctuations in the range of 75.3 ± 1.0% as the ratio of added AC increased. However, TOL significantly inhibited the degradation of EA, and AC, and more seriously on AC. When the ratio of added TOL increased, the degradation rates of EA or AC changed from 41.1% or 34.5% to 29.8% or 12.2%, which were 11.3% or 22.3% reduced respectively. It’s indicated that there was a mutual inhibitory effect between the AC and EA when they were degraded together, and a stronger inhibitory effect of EA on AC was observed. When the ratio of added AC to EA changed from 0:1 to 3:1, the degradation rate of EA decreased by 9.5%, from 49.8% to 40.3%. When the ratio of added EA to AC changed from 0:1 to 3:1, the degradation rate of AC decreased by 16.0%, from 37.9% to 21.9%.