Impact of walnut consumption on cardio metabolic and anthropometric parameters in metabolic syndrome patients: GRADE-assessed systematic review and dose-response meta-analysis of data from randomized controlled trials

Arabi, Seyyed Mostafa; Bahrami, Leila Sadat; Milkarizi, Narges; Nematy, Mohsen; Kalmykov, Vladislav; Sahebkar, Amirhossein

doi:10.1016/j.phrs.2022.106190

Cited by 15 publications

(20 citation statements)

References 59 publications

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“…The results of our study showed no significant effects of walnut intake on inflammatory markers. These findings concur with recently published data showing that the hs-CRP level was not influenced by walnut consumption [ 53 ]. Moreover, our findings agree with a recently published meta-analysis of both interventional and observational studies, which established that walnut intake had no statistical significance on glucose homeostasis and inflammation [ 22 ].…”

Section: Discussionsupporting

confidence: 93%

“…In our study, the effect on blood pressure was analyzed in eight trials. Neither SBP nor DBP was significantly modified by walnut-enhanced diets, confirming the results of previous analyses [ 53 , 55 , 60 ]. Furthermore, our study did not show statistically significant changes in terms of glycemic markers, which also corroborated prior studies [ 22 , 51 , 53 ].…”

Section: Discussionsupporting

confidence: 90%

“…Neither SBP nor DBP was significantly modified by walnut-enhanced diets, confirming the results of previous analyses [ 53 , 55 , 60 ]. Furthermore, our study did not show statistically significant changes in terms of glycemic markers, which also corroborated prior studies [ 22 , 51 , 53 ]. After following walnut-enriched diets, the anthropometric parameters did not show significant differences compared to the control.…”

Section: Discussionsupporting

confidence: 90%

“…Different doses of walnut showed that the subgroup exposed to walnut portions greater than 42 g per day had statistically significant results. This result reinforces the Food and Drug Administration (FDA) [ 52 ] recommendation for the inclusion of 42 g (1.5 ounces) of walnuts in the daily diet and differs from the conclusions of another meta-analysis, which states that the TG lowering effects reach a plateau at doses higher than 20 g [ 53 ].…”

Section: Discussionsupporting

confidence: 57%

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Walnut Intake Interventions Targeting Biomarkers of Metabolic Syndrome and Inflammation in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2022

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Biomarkers of metabolic syndrome and inflammation are pathophysiological predictors and factors of senescence and age-related diseases. Recent evidence showed that particular diet components, such as walnuts rich in antioxidant bioactive compounds and with a balanced lipid profile, could have positive outcomes on human health. A systematic search in PubMed, EMBASE, Cochrane Library, Scopus, and ClinicalTrials.gov databases was performed to retrieve randomized controlled trials published from the beginning of each database through November 2021, reporting on the outcomes of walnut consumption over 22 metabolic syndrome and inflammatory markers in middle-aged and older adults. The search strategy rendered 17 studies in the final selection, including 11 crossover and 6 parallel trials. The study revealed that walnut-enriched diets had statistically significant decreasing effects for triglyceride, total cholesterol, and LDL cholesterol concentrations on some inflammatory markers and presented no consequences on anthropometric and glycemic parameters. Although further studies and better-designed ones are needed to strengthen these findings, the results emphasize the benefits of including walnuts in the dietary plans of this age group.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 57%

See 2 more Smart Citations

Walnut Intake Interventions Targeting Biomarkers of Metabolic Syndrome and Inflammation in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2022

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“…However, the PCOS with Oligo/amenorrhoea were combined into a group, without comparing with each other. Because the dose-response relationship is a powerful instructor for quantitatively showing the strength of association [17][18][19], and is widely used for metabolic indexes [20,21], the association between IR and abnormal menstrual cycles in PCOS should be further studied.…”

Section: Introductionmentioning

confidence: 99%

Association between insulin resistance and abnormal menstrual cycle in Chinese patients with polycystic ovary syndrome

Niu¹,

Lu²,

Liu³

2022

Preprint

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Background: Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, which is characterized by insulin resistance (IR) and menstrual cycle disorders. IR is thought of as a pivotal cause of PCOS and related comorbidities. However, the link between IR and abnormal menstrual cycles in PCOS should be further studied. In this study, we aimed to clarify the dose-response relationship between IR and abnormal menstrual cycles in patients with PCOS. Results: In this retrospective study including140 patients with PCOS, we found that there was a dose-response relationship between the increased HOMA-IR index and the level of menstrual cycle disorders (1.610 [95%CI: 1.37-1.85] for normal menstruation, 2.020 [95%CI: 1.61-2.44] for oligomenorrhea, 2.350 [95%CI:1.96-2.75] for amenorrhea, Pfor trend = 0.003). Further stratification analyses showed that this dose-response relationship was more evident in the patients who were younger than 25 years, had higher AFC numbers and had elevated levels of testosterone, anti-Müllerian hormone, inhibin B, and prolactin levels. Conclusions: Our study has established an association between IR and abnormal menstrual cycles in patients with PCOS, which can be affected by age and aberrant hormone levels. Our results might be helpful for further prevention and treatment of amenorrhea in PCOS.

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Medicinal and Nutritional Importance of Juglans regia Linn. on Human Health

Quratul-ain,

Shadab,

Siddiqui

2024

Medicinal Plants and Their Bioactive Compounds in Human Health: Volume 1

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Impact of walnut consumption on cardio metabolic and anthropometric parameters in metabolic syndrome patients: GRADE-assessed systematic review and dose-response meta-analysis of data from randomized controlled trials

Cited by 15 publications

References 59 publications

Walnut Intake Interventions Targeting Biomarkers of Metabolic Syndrome and Inflammation in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Walnut Intake Interventions Targeting Biomarkers of Metabolic Syndrome and Inflammation in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Association between insulin resistance and abnormal menstrual cycle in Chinese patients with polycystic ovary syndrome

Medicinal and Nutritional Importance of Juglans regia Linn. on Human Health

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