Impact of WNT1-inducible signaling pathway protein-1 (WISP-1) genetic polymorphisms and clinical aspects of breast cancer

Abstract

Breast cancer is the most common diagnosed malignancy in women. This study genotyped blood samples from 236 Han Chinese women with breast cancer and 128 healthy controls for single nucleotide polymorphisms (SNPs) rs2977537, rs2929970, rs2929973, rs2977530, and rs62514004, to determine whether these WNT1-inducible signaling pathway protein 1 (WISP-1) genetic polymorphisms increase the risk of developing breast cancer. Compared with wild-type (AA) carriers, those carrying the WISP1 rs62514004 AG or AG + GG genetic variants had a greater risk of developing breast cancer. In an evaluation of the association between clinicopathological aspects and the WISP1 SNP rs62514004 in the breast cancer cohort, patients with the GG genotype were less likely than those with the AA genotype to develop stage III/IV disease. Patients carrying the WISP1 rs2929973 GG + TT variant were almost twice as likely as those carrying the GT genotype to have estrogen receptor (ER)- and progesterone receptor (PR)-positive tumors, while those with the WISP1 rs62514004 AG + GG genetic variants were around twice as likely as those with the AA genotype to have HER2-positive tumors. This study details risk associations between WISP1 SNPs and breast cancer susceptibility in women of Han Chinese ethnicity.

Association of WNT-1 Inducible Signaling Pathway Protein-1 (WISP1) Genetic Polymorphisms with the Risk of Gastric Cancer in Guangxi Chinese

“…WISP1 polymorphisms have been identi ed in various cancers, including breast cancer [13], urothelial cell carcinoma [14], hepatocellular carcinoma [15], oral squamous cell carcinoma [16], lung cancer [17], uterine cervical cancer [18], but data are scant as to the involvement of WISP1 polymorphisms in gastric cancer. As far as we are aware, our study is the rst to investigate the distributions of the rs2929973, rs7843546 and rs10956697 SNPs and their associations with the development gastric cancer in Guangxi Chinese population.…”

“…In this study, SNPs were selected based on data from the International HapMap Project (http://hapmap.ncbi.nlm.nih.gov/), dbSNP database (http://www.ncbi.nlm.nih.gov/projects/SNP/) and the nding of previous studies reported the effect of WISP1 genetic polymorphisms on cancer susceptibility [14][15][16][17][18][19]21]. All SNPs had minor allele frequencies (MAF) of > 5% to prevent false negative results.…”

“…WISP1 gene is constituted of 5 exons and 4 introns, located on chromosome 8q24.1 to 8q24.3 and has been shown to be highly polymorphic [13]. Several clinical studies have indicated a signi cant association between WISP1 polymorphisms and various cancers, such as breast cancer [14], urothelial cell carcinoma [15], hepatocellular carcinoma [16], oral squamous cell carcinoma [17], lung cancer [18], uterine cervical cancer [19]. Up until now, to our knowledge, no study has established a connection between WISP1 genetic polymorphisms and gastric cancer.…”

An Update to the WISP-1/CCN4 Role in Obesity, Insulin Resistance and Diabetes

“…The role of WISP-1 in tumorigenesis has been studied in many types of neoplasms, where it acts as an autocrine and paracrine modulator, increasing cell migration [ 10 ]. Furthermore, the WISP-1 gene’s polymorphisms were shown to impact the breast cancer susceptibility and the expression of oestrogen and progesterone receptors in the tumour [ 16 ].…”

Association between tobacco substance usage and a missense mutation in the tumor suppressor gene P53 in the Saudi Arabian population

“…TSU has been shown to affect the gene expression of P53 [ 25 ] by altering its negative regulator, the MDM2 gene [ 26 ], which in turn causes MDM2 upregulation in the lungs of cancer patients who are smokers [ 27 ]. Recently, single-nucleotide polymorphisms (SNPs) have also been linked to various diseases, including celiac disease [ 28 ], rheumatoid arthritis [ 29 ], bipolar disorder [ 30 ], and asthma [ 31 , 32 ], as well as lung [ 33 ], gastric [ 34 ], ovarian [ 35 ], and breast cancers [ 36 ]. Other studies have also demonstrated that TSU causes SNPs that affect gene expression in various locations in the genome [ 37 , 38 ].…”