Impact of xerostomia on the quality of life of patients submitted to head and neck radiotherapy

Nascimento, Michele Lopes do; Farias, Andreza Barkokebas Santos de; Carvalho, Alessandra Albuquerque Tavares; Albuquerque, Raylane Farias De; Ribeiro, Lucas Nascimento; Leão, Jair Carneiro; Silva, Igor Henrique Morais

doi:10.4317/medoral.23131

Cited by 29 publications

(21 citation statements)

References 24 publications

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“…Similar studies have reported that xerostomia significantly reduced OHRQOL. 12 , 29 , 37 Niklander et al. reported a significant difference between OHRQOL and the presence or absence of xerostomia, with a mean S–OHIP score of 20.1 ± 14.32 in the xerostomic group 12 compared to our study, in which comparatively lower median scores were reported on S–OHIP.…”

Section: Discussioncontrasting

confidence: 70%

Determining the relationship among stress, xerostomia, salivary flow rate, and the quality of life of undergraduate dental students

Atif

Syed

Sherazi

et al. 2021

Journal of Taibah University Medical Sciences

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Objective Xerostomia may result in several oral conditions, which ultimately affect oral health-related quality of life (OHRQOL). This study aims to evaluate the relationship of stress, xerostomia, salivary flow rate, and OHRQOL among young adults. Method We invited 72 participants to complete three validated questionnaires including the Perceived Stress Scale-10 (PSS-10), a shortened version of the Xerostomia Inventory (SXI), and the shortened Oral Health Impact Profile (S–OHIP). Unstimulated saliva was collected, and flow rate was determined. Based on the SXI scores and hyposalivation, the participants were categorised into four groups: subjective xerostomia, subjective and objective xerostomia, objective xerostomia, and true non-xerostomia. Based on the median PSS score, participants were categorised into high stress and low stress groups. Data were analysed using the Mann–Whitney U test, Kruskal–Wallis H test, and Spearman's correlation coefficient. A p value of 0.05 was set for all tests. Results A significant difference was observed in the unstimulated salivary flow rate (χ 2 (3) = 26.677, p < 0.001) and PSS scores (X 2 (3) = 8.552, p = 0.036) between xerostomia groups, while OHIP scores were not statistically different (X 2 (3) = 5.488, p = 0.139). A significant correlation was observed between SXI and S–OHIP scores ( r = 0.348, p = 0.003) and unstimulated salivary flow rate and PSS ( r = −0.259, p = 0.028). Conclusion This study shows that perceived stress can influence salivary flow rate. Among the xerostomia groups, stress scores and salivary flow rates varied significantly. Additionally, subjective xerostomia has an impact on OHRQOL.

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Section: Discussioncontrasting

confidence: 70%

Determining the relationship among stress, xerostomia, salivary flow rate, and the quality of life of undergraduate dental students

Atif

Syed

Sherazi

et al. 2021

Journal of Taibah University Medical Sciences

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“…Xerostomia may develop because of salivary gland injury and reduced or absent salivary flow among patients with head and neck cancer (HNC) 1,2 . Xerostomia may lead to oral problems, including pain, dysphagia, speech difficulty, a reduced or altered sense of taste, an increased risk of dental caries, infections, and osteoradionecrosis 3 . Xerostomia has been numbered among the top 5 most severely reported symptoms in patients with long‐term oropharyngeal cancer (OPC) 4 .…”

Section: Introductionmentioning

confidence: 99%

Determinants of patient‐reported xerostomia among long‐term oropharyngeal cancer survivors

Aggarwal

Hutcheson

Garden

et al. 2021

Cancer

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Background This study was conducted to identify clinicodemographic risk factors for xerostomia among long‐term oropharyngeal cancer (OPC) survivors. Methods This cross‐sectional study included 906 disease‐free, adult OPC survivors with a median survival duration at the time of survey of 6 years (range, 1‐16 years); self‐reported xerostomia scores were available for 877 participants. Study participants had completed curative treatment between January 2000 and December 2013 and responded to a survey administered from September 2015 to July 2016. The primary outcome variable was cancer patient–reported xerostomia measured with the MD Anderson Symptom Inventory Head and Neck Cancer Module. Clinicodemographic risk factors for moderate to severe xerostomia were identified via multivariable logistic regression. Results Moderate to severe xerostomia was reported by 343 of the respondents (39.1%). Female sex (odds ratio [OR], 1.82; 95% CI, 1.22‐2.71; P = .003; Bayesian false‐discovery probability [BFDP] = 0.568), high school or lower education (OR, 1.73; 95% CI, 1.19‐2.52; P = .004; BFDP = 0.636), and current cigarette smoking at the time of survey (OR, 2.56; 95% CI, 1.19‐5.47; P = .016; BFDP = 0.800) were risk factors for moderate to severe xerostomia, and bilateral intensity‐modulated radiotherapy (IMRT) combined with proton therapy and ipsilateral IMRT were protective. Conclusions In this large xerostomia study, modern radiotherapy was a protective factor, and continued cigarette smoking at the time of survey, female sex, and high school or lower education were identified as other contributing risk factors associated with moderate to severe xerostomia. Importantly, these findings need to be confirmed in prospective studies. These results can inform future research and targeted patient‐centered interventions to monitor and manage radiation therapy–associated xerostomia and preserve quality of life among patients with OPC.

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“…In the current study, 86.8% of people complained of xerostomia more often or always. One study showed that 97.5% of individuals complained of xerostomia at the end of radiotherapy [24]. The xerostomia is one of the most common and unpleasant side effects of radiotherapy of head and neck cancers [25].…”

Section: Discussionmentioning

confidence: 99%

Quality of Life in Iranian Patients with Oral and Head and Neck Cancer

Torabi

Jahanian

Afshar

2021

Pesqui. Bras. Odontopediatria Clín. Integr.

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Objective: To assess sociodemographic factors and cancer information on patients' quality of life with head and neck cancer. Material and Methods: This cross-sectional study was conducted on 69 patients with head and neck cancer who attended in one of the oncology centers in Mashhad, Iran, from September 2019 to December 2019. Data was collected through a questionnaire consisted of demographic information (gender, age, educational level, and job) and cancer information (type, location, treatment, clinical stage) and standard quality of life questionnaire (QLQ-H&N35). Data analyzed in SPSS22 software using T, ANOVA, Linear regression tests at 0.05 significant levels. Results: 49 participants (72.1%) were men. The mean age was 60.48 ± 13.74 years. Forty-nine participants (72.1%) had squamous cell carcinoma and 26 participants (38.2%) had a larynx tumor. Forty-six participants (67.6%) were in clinical stage 3, mainly with a problem and complain about hard food swallowing, xerostomia and speech. The mean score of QLQ-H&N35 was 42.06 ± 20.12 from 90. Quality of life in 47.1% of cases was moderate. There was no significant relationship between gender, job, educational level, type and location of cancer (p>0.05). There was a significant relationship between the patient's age, clinical stage, type of treatment, and quality of life (p<0.05). Conclusion: Quality of life in 47.1% was moderate. Clinical stage, age of patients and type of treatment statically and significantly affected the quality of life. Assessing quality of life in HNC patients can identify important side effects of treatment that affected quality of life and look for ways to improve QoL.

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Impact of xerostomia on the quality of life of patients submitted to head and neck radiotherapy

Cited by 29 publications

References 24 publications

Determining the relationship among stress, xerostomia, salivary flow rate, and the quality of life of undergraduate dental students

Determining the relationship among stress, xerostomia, salivary flow rate, and the quality of life of undergraduate dental students

Determinants of patient‐reported xerostomia among long‐term oropharyngeal cancer survivors

Quality of Life in Iranian Patients with Oral and Head and Neck Cancer

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