Impact of Zygomycosis on Microbiology Workload: a Survey Study in Spain

Torres-Narbona, Marta; Guinea, Jesús; Martínez-Alarcón, José; Muñóz, Patricia; Gadea, Ignacio

doi:10.1128/jcm.02473-06

Cited by 101 publications

(62 citation statements)

References 27 publications

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“…A previous report by our group showed that, in 2005, Spanish microbiology laboratories isolated zygomycetes in only 6 per 100,000 samples [35]. We were unable to demonstrate any substantial increase in the isolation of zygomycetes in our institution in the last 10 years.…”

Section: Discussioncontrasting

confidence: 75%

Workload and clinical significance of the isolation of zygomycetes in a tertiary general hospital

et al. 2008

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Several reports of increases in invasive zygomycosis (IZ) at individual institutions across the USA and Europe have contributed to a generalized concept that IZ is an increasing problem and the overestimation of the clinical significance of the isolation of zygomycetes in microbiology departments. We assessed the workload and clinical significance of zygomycetes isolates recovered from clinical samples in our institution over a 19-year period (1988-2006). We retrospectively reviewed the charts of those patients from who isolates of zygomycetes were obtained and calculated the workload of its isolation, the incidence of IZ during this period and the positive predictive value (PPV) of a positive culture. Zygomycetes were recovered from 210 samples (176 patients), i.e., 0.086/1,000 clinical samples processed and 6.3/1,000 samples submitted for fungal isolation. Zygomycetes represented 0.6% of the total fungi recovered. The mean incidence of the disease was 1.2 cases/100,000 admissions (range 0-20). Only 16 of the samples which grew zygomycetes (7.6%) were from infected patients. The workload generated by zygomycetes in our institution and the PPV for IZ of their isolation in our laboratory were very low and the disease was not found to have significantly increased in recent years in our institution. Data from specific institutions cannot be generalized.

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Section: Discussioncontrasting

confidence: 75%

Workload and clinical significance of the isolation of zygomycetes in a tertiary general hospital

et al. 2008

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“…For mucormycosis, we used a rate of 0.43 cases per 1 million inhabitants, as previously documented [35].…”

Section: Methodsmentioning

confidence: 99%

“…Other cases of cryptococcal meningitis occur, but we have no reliable means to estimate this. For mucormycosis, a Spanish study found an incidence rate of 0.04 cases per 100 000 inhabitants that suggests 20 cases every year [35]. However, in France, a neighbouring country, the incidence recently found was 0.12 cases per 100 000 inhabitants.…”

Section: Other Fungal Infectionsmentioning

confidence: 96%

Burden of serious fungal infections in Spain

Rodriguez-Tudela¹,

Alastruey‐Izquierdo

Gago³

et al. 2015

Clinical Microbiology and Infection

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Estimates of the incidence and prevalence of serious fungal infections, based on epidemiological data, are essential in order to inform public health priorities given the lack of resources dedicated to the diagnosis and treatment of these serious fungal diseases. However, epidemiology of these infections is largely unknown, except for candidaemia and cryptococcosis. The aim of this work is to calculate the burden of serious fungal infections in Spain. All published epidemiology papers reporting fungal infection rates from Spain were identified. Where no data existed, we used specific populations at risk and fungal infection frequencies in those populations to estimate national incidence or prevalence, depending on the condition. Around 8.1 million people suffer a fungal infection every year. Most of them are skin or mucosal infections causing no deaths. Candidaemia is more common than in other European countries and has risen by 1.88-fold in frequency in the last decade (8.1 cases × 100,000). Good estimates of invasive aspergillosis (2.75 cases × 100,000) and mucormycosis (0.04 × 100,000) are available. Fungal infections with a high mortality such as invasive aspergillosis, candidaemia, Pneumocystis pneumonia and mucormycosis are not numerous in Spain, but they affect those with severe underlying diseases and are therefore linked to poor outcomes. Additional studies are required, especially for high burden diseases such as recurrent thrush in women (∼9000 cases × 100,000 women), allergic bronchopulmonary aspergillosis (126 cases × 100,000) and severe asthma with fungal sensitisation (198 cases × 100,000).

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“…En un estudio que reunió datos de 50 hospitales de España, el aislamiento de Zygomycetes fue muy bajo, demostrando que menos del 8% de los pacientes con cultivo positivo estaban realmente infectados, mientras que la gran mayoría presentaban colonización o contaminación de laboratorio (33). Aún así, consideramos que, si bien la trascendencia del cultivo puede ser baja, el aislamiento de estos hongos tiene importancia si se considera el tipo de lesión y procedencia de la muestra clínica.…”

Section: Discusionunclassified

“…En estos últimos años se ha descrito un incremento importante en la incidencia de esta enfermedad en instituciones aisladas o unidades específicas alcanzando un 8% en pacientes con leucemia. Este aumento del número de casos se produce generalmente en pacientes y unidades donde se administra con exceso profilaxis antibacteriana de amplio espectro, sin la sospecha de una micosis (33). …”

Section: Discusionunclassified