Background: There are several efforts to address impacted teeth, one of which is through a minor surgical intervention called Odontectomy. There are also several complications that may arise after Odontectomy is performed, but this usually only occurs for a few days, and patients will experience a more comfortable feeling compared to before the Odontectomy. This research aims to analyze the difference in the quality of life of patients before and after the Odontectomy surgical procedure. Material and Methods: The method employed in this research was analytical observational, using a Cross-Sectional design. The sampling technique used was Accidental sampling, which involved patients who underwent Odontectomy at Bhayangkara Hospital Semarang Indonesia in October 2023. The total sample size was 10 patients based on inclusion criteria. The research was conducted using the OHIP-14 (Oral Health Impact Profile 14) questionnaire, consisting of 14 questions from 7 dimensions. Data analysis was performed using the Wilcoxon test because the data scale was ordinal. Results: The results of this study indicated that before undergoing Odontectomy, the quality of life of patients at a moderate level was 3 individuals (30%), while those at a low level were 7 individuals (70%). After Odontectomy was performed, the quality of life of patients improved, with 1 individual (10%) at a moderate level, 9 individuals (90%) at a good level, and 1 individual (10%) at a very good level. The statistical analysis results showed that the significance value (P) was 0.005, indicating that p < 0.05. Conclusion: The conclusion that can be drawn from this research is that there was a significant difference in the quality of life of patients before and after undergoing the Odontectomy procedure.