Introduction: a good state of oral health provides the individual with a state of well-being and physical, mental and social satisfaction; It is due to the ability of the mouth, especially the teeth, to transmit emotions such as joy through a smile.Objective: to describe the impact of gram-negative bacteria on oral healthMethod: the information search was carried out in the databases: Scielo, PubMed and SCOPUS, in addition to other data sources such as search engines and institutional repositories. Selection criteria were applied for the selection of bibliographic sources. 23 sources were used for the development of the researchDevelopment: Oral health in general is considered an important factor in the analysis of the health situation of countries. The mouth is home to the second most diverse microbial community in the body (after the intestine), with more than 700 species of bacteria. Likewise, it is valid to emphasize that these bacteria are potentially greater in virulence than viruses. Odontogenic infections can spread rapidly and compromise neurovascular structures and airway patency; They are not caused by a single organism; instead, they are polymicrobial in nature. Gram-negative bacteria have special relevance in the development of oral diseases. One of the peculiarities of this group of biological agents is their high capacity for antimicrobial resistance.Conclusions: Gram-negative bacteria have a variable impact on oral health. There are many bacterial species and etiological agents that can influence the development of oral conditions. These are made up of diseases such as cavities, gingivitis until they evolve over time without adequate treatment or with a poor response to periodontitis. In turn, gram-negative bacteria provide extensive resistance to the treatment of these pathologies, which is why they require special attention in their management and monitoring due to the multiple systemic complications that can develop