Impacto del uso de edulcorantes no calóricos en la salud cardiometabólica

Manzur, Fernando; Morales-Núñez, María Angélica; Ordosgoitia-Morales, José; Quiroz-Mendoza, Rosalinda; Ramos-Villegas, Yancarlos; Corrales-Santander, Hugo

doi:10.1016/j.rccar.2019.11.003

Cited by 8 publications

(4 citation statements)

References 17 publications

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“…Sweeteners are all those substances or additives, other than monosaccharides, disaccharides, oligosaccharides, or sugars, that can give a characteristic sweet taste to the products of different industries, especially the food industry [ 1 ]. The foregoing allows generating a pleasant sensation on the consumer’s palate and arouse preference for these industrialized products, making them the most consumed from the first stages of life [ 1 , 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Caloric and Noncaloric Sweeteners Present in Dairy Products Aimed at the School Market and Their Possible Effects on Health

et al. 2021

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Over the past decades, Mexico has become one of the main sweetener-consuming countries in the world. Large amounts of these sweeteners are in dairy products aimed at the children’s market in various presentations such as yogurt, flavored milk, flan, and cheeses. Although numerous studies have shown the impact of sweeteners in adults, the current evidence for children is insufficient and discordant to determine if these substances have any risk or benefit on their well-being. Therefore, this study aimed to describe the sweeteners present in 15 dairy products belonging to the school-age children’s market in Mexico and their impact on health. These dairy products were selected through a couple of surveys directed at parents of school-age children. After that, the list of ingredients of each product was analyzed to identify their sweetener content. From there, exhaustive bibliographic research on sweeteners and their possible health effects was carried out, which included 109 articles and 18 studies. The results showed that at a neurological, endocrinological, cardiovascular, metabolic, osseous, renal, hepatic, dental, reticular, carcinogenic, and gut microbiota level; sucrose, fructose, high-fructose corn syrup, maltodextrins, sucralose, and acesulfame K, have a negative effect. While maltodextrins, stevia, polydextrose, and modified starch have a positive one. For these reasons, it is necessary to evaluate the advantages and disadvantages that the consumption of each sweetener entails, as well as a determination of the appropriate acceptable daily intake (ADI).

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Section: Introductionmentioning

confidence: 99%

“…On the other hand, noncaloric sweeteners emerge as a strategy to reduce caloric sweetener intake and to prevent noncommunicable diseases (obesity, metabolic syndrome, and diabetes). Among this type of sweetener, sucralose and stevia stand out [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Caloric and Noncaloric Sweeteners Present in Dairy Products Aimed at the School Market and Their Possible Effects on Health

et al. 2021

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“…Al respecto, Pepino [16] propone que estos sustitutivos pueden desempeñar un papel activo a nivel del tracto gastrointestinal al reaccionar con los receptores del sabor dulce como T1R2 y T1R3, mediando así cambios en la respuesta de hormonas y péptidos como los relacionados con glucagón (GLP), presentes en las células L del tracto intestinal, lo cual culmina en un aumento de la secreción de GLP-1 y de la liberación de insulina que afecta tanto al peso como al apetito y a la glucemia. En este sentido, se ha sugerido que la secreción de incretinas (encargadas de regular la secreción de insulina y el glucagón dependientes de la glucosa) aumenta con el uso de edulcorantes, siendo el acesulfame el que tiene mayor capacidad secretora [17]. Otro mecanismo postula que las respuestas siológicas que mantienen la homeostasis energética pueden verse afectadas por el consumo de edulcorantes [18,19].…”

Section: Fisiopatología De Los Edulcorantes No Calóricos En La Enfermedad Renalunclassified

Edulcorantes artificiales y su papel en la enfermedad renal crónica

Bohórquez-Rivero

López

Restom-Arrieta

et al. 2021

Rev. Colomb. Nefrol.

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Los edulcorantes artificiales no calóricos han surgido para ofrecer una opción segura y saludable en el marco de la alimentación. Han abarcado especial atención en las ultimas décadas, precisamente por la cultura de alimentación adquirida en la actualidad, donde ha tomado especial fuerza la alimentación con la comida rápida y el alto consumo de azúcar, lo que repercute negativamente en la incidencia de enfermedades metabólicas. En ese orden de ideas los edulcorantes artificiales no calóricos, proponen una mejor salud sin la necesidad de un cambio drástico en el estilo de vida. Empero, sus beneficios no han sido estudiados a profundidad, además de que no ha habido un cambio significativo en el desarrollo de enfermedades metabólicas asociadas al consumo de azúcar, por el contrario, se han relacionado con enfermedades como la obesidad, diabetes mellitus tipo 2 y síndrome metabólico. Así mismo, provocan una serie de cambios metabólicos por distintos mecanismos que terminan en proteinuria progresiva y el descenso de la tasa de filtrado glomerular. En orden con lo anterior, se hace necesario un análisis del riesgo al que se está sometido al elegir esta opción alimenticia, y no dejarse ensordecer ni mucho menos deslumbrar por los procesos mediáticos, si no mas bien, regirse por los hallazgos científicos.

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“…Originally intended for individuals with obesity and diabetes due to its ability to avert glycemic spikes and reduce caloric intake while maintaining sweetness [ 6 ], sucralose has become a ubiquitous sweetener across diverse demographics. Boasting unique characteristics such as prolonged solid-state stability and resilience in solutions with varying pH levels [ 7 ], it remains 600 times sweeter than regular sugar, with a bacteriostatic effect that prevents dental caries [ 8 , 9 ]. For years, sucralose has been regarded as a harmless substance.…”

Section: Introductionmentioning

confidence: 99%

Sucralose: From Sweet Success to Metabolic Controversies—Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial Sweetener

Aguayo-Guerrero,

Méndez-García,

Solleiro-Villavicencio

et al. 2024

Life

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Sucralose is a food additive initially used to mitigate glycemic peaks and calorie intake in patients with diabetes and obesity. Although sucralose has been considered safe for human consumption, the World Health Organization (WHO) issued a global alert in 2023 concerning the potential health implications of this artificial sweetener. This review aims to comprehensively explore the effects of sucralose intake on human health by understanding sucralose absorption, metabolism, and excretion. We also outline the role of the sweet taste 1 receptor 3 (T1R3) in mediating sucralose-dependent signaling pathways that regulate satiety, incretin release, and insulin response. Finally, we discuss the impact of sucralose on microbiome dysbiosis, inflammatory response origin, liver damage, and toxicity. Gaining a deeper understanding of the manifold effects of sucralose on human physiology will help promote further studies to ensure its consumption is deemed safe for a broader population, including children, adolescents, and pregnant women.

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Impacto del uso de edulcorantes no calóricos en la salud cardiometabólica

Cited by 8 publications

References 17 publications

Analysis of Caloric and Noncaloric Sweeteners Present in Dairy Products Aimed at the School Market and Their Possible Effects on Health

Analysis of Caloric and Noncaloric Sweeteners Present in Dairy Products Aimed at the School Market and Their Possible Effects on Health

Edulcorantes artificiales y su papel en la enfermedad renal crónica

Sucralose: From Sweet Success to Metabolic Controversies—Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial Sweetener

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