IMPACTO-MR: um estudo brasileiro de plataforma nacional para avaliar infecções e
            multirresistência em unidades de terapia intensiva

Tomazini, Bruno Martins; Júnior, Antonio Paulo Nassar; Lisboa, Thiago; Azevedo, Luciano César Pontes; Veiga, Viviane Cordeiro; Catarino, Daniela Ghidetti Mangas; Fogazzi, Débora Vacaro; Arns, Beatriz; Piastrelli, Filipe; Dietrich, Camila; Negrelli, Karina Leal; Jesuíno, Isabella de Andrade; Reis, Luiz F. L.; Mattos, Renata Rodrigues de; Pinheiro, Carla Cristina Gomes; Luz, Mariane Nascimento; Spadoni, Clayse Carla da Silva; Moro, Elisângela Emilene; Bueno, Flávia Regina; Sampaio, Camila Santana Justo Cintra; Silva, Débora Patrício; Baldassare, Franca Pellison; Silva, Ana Cecilia Alcantara; Veiga, Thabata; Barbante, Leticia; Lambauer, Marianne; Campos, Viviane Bezerra; Santos, Elton J. G.; Santos, Renato Hideo Nakawaga; Laranjeiras, Ligia Nasi; Valeis, Nanci; Santucci, Eliana Vieira; Miranda, Tamiris Abait; Patrocínio, Ana Cristina Lagoeiro do; Carvalho, Andréa de; Sousa, Eduvirgens Maria Couto de; Sousa, Ancelmo Honorato Ferraz de; Malheiro, Daniel Tavares; Bezerra, Isabella Lott; Rodrigues, Mirian Batista; Malicia, Julliana Chicuta; Silva, Sabrina Souza da; Gimenes, Bruna dos Passos; Sesin, Guilhermo Prates; Zavascki, Alexandre Prehn; Sganzerla, Daniel; Medeiros, Gregory Saraiva; Santos, Rosa da Rosa Minho dos; Silva, Fernanda Kelly Romeiro; Cheno, Maysa Yukari; Abrahão, Carolinne Ferreira; Oliveira, Haliton Alves de; Rocha, Leonardo Lima; Neto, Pedro Aniceto Nunes; Pereira, Valéria Chagas; Paciência, Luís Eduardo Miranda; Bueno, Elaine Silva; Caser, Eliana Bernadete; Ribeiro, Larissa Zuqui; Fernandes, Caio César Ferreira; Garcia, Juliana Mazzei; Silva, Vanildes de Fátima Fernandes; Santos, Alexandre Bessa dos; Machado, Flávia Ribeiro; Souza, Maria Aparecida de; Ferronato, Bianca Ramos; Urbano, Hugo Corrêa de Andrade; Moreira, Danielle Conceição Aparecida; Souza-Dantas, Vicente Cés de; Duarte, Diego Meireles; Coelho, Juliana Chaves; Figueiredo, Rodrigo Cruvinel; Foreque, Fernanda; Romano, Thiago Gomes; Cubos, Daniel; Spirale, Vladimir Miguel; Nogueira, Roberta Schiavon; Maia, Israel Silva; Zandonai, C.; Lovato, Wilson José; Cerantola, Rodrigo Barbosa; Toledo, Tatiana Gozzi Pancev; Tomba, Pablo Oscar; Almeida, Joyce Ramos de; Sanches, Luciana Coelho; Pierini, Leticia; Cunha, Mariana Regina da; Sousa, Michelle Tereza; Azevedo, Bruna Marcacini; Dal‐Pizzol, Felipe; Damasio, Danusa de Castro; Bainy, Marina Peres; Beduhn, Dagoberta Alves Vieira; Jatobá, Joana D’Arc Vila Nova; Moura, Maria Tereza Farias de; Rego, Leila Rezegue de Moraes; Silva, Adria Vanessa da; Oliveira, Luana Pontes; Filho, Eliene Sá Sodré; Santos, S.; Neves, Itallo de Lima; Leão, Vanessa Cristina de Aquino; Paes, João Lucidio Lobato; Silva, Marielle Cristina Mendes; Oliveira, Cláudio Dornas de; Santiago, Raquel Caldeira Brant; Paranhos, Jorge; Wiermann, Iany Grinezia da Silva; Pedroso, Durval Ferreira Fonseca; Sawada, Priscilla Yoshiko; Prestes, Rejane Martins; Nascimento, Glícia Cardoso; Grion, Cíntia Magalhães Carvalho; Carrilho, Cláudia Maria Dantas de Maio; Dantas, Roberta Lacerda Almeida de Miranda; Silva, Eliane Pereira; Silva, Antônio Carlos da; Oliveira, Sheila Mara Bezerra de; Golin, Nicole Alberti; Tregnago, Rogerio; Lima, Valéria Paes; Silva, Kamilla Grasielle Nunes da; Boschi, Emerson; Buffon, Viviane Aline; Machado, André Sant’Ana; Capeletti, Leticia; Foernges, Rafael Botelho; Carvalho, Andréia Schubert de; Jr, Lúcio Couto de Oliveira; Oliveira, Daniela; Silva, Everton Macêdo; Ribeiro, Julival; Pereira, Francielle Constantino; Salgado, Fernanda Borges; Deutschendorf, Caroline; Silva, Cristófer Farias da; Gobatto, André Luiz Nunes; Oliveira, Carolaine Bomfim de; Dracoulakis, Marianna Deway Andrade; Alvaia, Natália Oliveira Santos; Souza, Roberta Machado de; Araújo, Larissa Liz Cardoso de; Melo, Rodrigo Morel Vieira de; Passos, Luiz Carlos Santana; Vidal, Cláudia Fernanda de Lacerda; Rodrigues, Fernanda Lopes de Albuquerque; Kurtz, Pedro; Shinotsuka, Cássia Righy; Tavares, Maria Brandão; Santana, Igor das Virgens; Gavinho, Luciana Macedo da Silva; Nascimento, Alaís Brito; Pereira, Adriano José; Cavalcanti, Alexandre Biasi

doi:10.5935/0103-507x.20220209-pt

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…Com a participação de mais de 50 unidades de terapia intensiva e o registro de mais de 70 mil pacientes, essa plataforma oferece informações valiosas para o desenvolvimento e pesquisa de unidades de terapia intensiva individuais, bem como para estudos observacionais e prospectivos multicêntricos. (VEIGA, V. et al, 2022).…”

Section: Resultsunclassified

Infecções Associadas À Assistência Em Unidades De Terapia Intensiva: Revisão Integrativa

Machado,

CARTAXO

2023

Anais Do I Congresso Nacional De Avanços Em Terapia Intensiva on-Line

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Section: Resultsunclassified

Infecções Associadas À Assistência Em Unidades De Terapia Intensiva: Revisão Integrativa

Machado,

CARTAXO

2023

Anais Do I Congresso Nacional De Avanços Em Terapia Intensiva on-Line

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Data and ICU registries to improve care delivery in low-resource settings

Amado,

Quintairos,

Lanziotti

et al. 2024

Intensive Care Med

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16S rRNA amplicon sequencing and antimicrobial resistance profile of intensive care units environment in 41 Brazilian hospitals

de Bastiani,

Silva,

Christoff

et al. 2024

Front. Public Health

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IntroductionInfections acquired during healthcare setting stay pose significant public health threats. These infections are known as Healthcare-Associated Infections (HAI), mostly caused by pathogenic bacteria, which exhibit a wide range of antimicrobial resistance. Currently, there is no knowledge about the global cleaning process of hospitals and the bacterial diversity found in ICUs of Brazilian hospitals contributing to HAI.ObjectiveCharacterize the microbiome and common antimicrobial resistance genes present in high-touch Intensive Care Unit (ICU) surfaces, and to identify the potential contamination of the sanitizers/processes used to clean hospital surfaces.MethodsIn this national, multicenter, observational, and prospective cohort, bacterial profiles and several antimicrobial resistance genes from 41 hospitals across 16 Brazilian states were evaluated. Using high-throughput 16S rRNA amplicon sequencing and real-time PCR, the bacterial abundance and resistance genes presence were analyzed in both ICU environments and cleaning products.ResultsWe identified a wide diversity of microbial populations with a recurring presence of HAI-related bacteria among most of the hospitals. The median bacterial positivity rate in surface samples was high (88.24%), varying from 21.62 to 100% in different hospitals. Hospitals with the highest bacterial load in samples were also the ones with highest HAI-related abundances. Streptococcus spp., Corynebacterium spp., Staphylococcus spp., Bacillus spp., Acinetobacter spp., and bacteria from the Flavobacteriaceae family were the microorganisms most found across all hospitals. Despite each hospital particularities in bacterial composition, clustering profiles were found for surfaces and locations in the ICU. Antimicrobial resistance genes mecA, blaKPC-like, blaNDM-like, and blaOXA-23-like were the most frequently detected in surface samples. A wide variety of sanitizers were collected, with 19 different active principles in-use, and 21% of the solutions collected showed viable bacterial growth with antimicrobial resistance genes detected.ConclusionThis study demonstrated a diverse and spread pattern of bacteria and antimicrobial resistance genes covering a large part of the national territory in ICU surface samples and in sanitizers solutions. This data should contribute to the adoption of surveillance programs to improve HAI control strategies and demonstrate that large-scale epidemiology studies must be performed to further understand the implications of bacterial contamination in hospital surfaces and sanitizer solutions.

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IMPACTO-MR: um estudo brasileiro de plataforma nacional para avaliar infecções e multirresistência em unidades de terapia intensiva

Cited by 4 publications

References 16 publications

Infecções Associadas À Assistência Em Unidades De Terapia Intensiva: Revisão Integrativa

Infecções Associadas À Assistência Em Unidades De Terapia Intensiva: Revisão Integrativa

Data and ICU registries to improve care delivery in low-resource settings

16S rRNA amplicon sequencing and antimicrobial resistance profile of intensive care units environment in 41 Brazilian hospitals

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