Impacts of Aging on Anemia Tolerance, Transfusion Thresholds, and Patient Blood Management

Simon, Geoff; Craswell, Alison; Thom, Ogilvie; Chew, Michelle; Anstey, Chris; Fung, Yoke Lin

doi:10.1016/j.tmrv.2019.03.001

Cited by 30 publications

(25 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anemia in the older population is reported to be related to various medical burdens, including increased morbidity and mortality [7]. In particular, anemia is reported to be related to higher cardiovascular events [8,9], frailty [3,10,11], fractures [12], prolonged hospital stays, and unfavorable outcomes [13][14][15]. Robins et al showed that anemia in older population possesses potential morbidity and mortality by affecting tissue oxygen delivery, accompanying the aging process, and eventually leading to multiple major and minor organ dysfunction, affecting both physical and mental functions [16].…”

Section: Introductionmentioning

confidence: 99%

High anemia prevalence in Korean older adults, an advent healthcare problem: 2007–2016 KNHANES

et al. 2020

View full text Add to dashboard Cite

Background Anemia is associated with high morbidity and mortality in older people. However, the prevalence and characteristics of anemia in older individuals are not fully understood, and national data on these aspects in older Korean adults are lacking. This study aimed to evaluate the prevalence and characteristics of anemia in older adults using data from the Korea National Health and Nutrition Examination Survey (KNHANES), which is a nationwide cross-sectional epidemiological study conducted by the Korean Ministry of Health and Welfare. Methods Data from a total of 62,825 participants of the 2007–2016 KNHANES were compiled and analyzed to investigate differences in participant characteristics and potential risk factors for anemia. Differences in clinical characteristics of participants were compared across subgroups using the chi-square test for categorical variables and independent t-test for continuous variables. Univariate and multivariate analyses using logistic regression were performed to identify related clinical factors. Results The prevalence of anemia was higher in the population aged ≥65 years than in the younger population. Anemia was also more prevalent among females than among males, but this difference was not significant in people aged > 85 years. Being underweight, receiving a social allowance, living alone, and having comorbidities such as hypertension, rheumatoid arthritis, diabetes mellitus (DM), cancer, and chronic renal failure (CRF) were more common among older adults with anemia than among the population without anemia. In univariate and multivariate analyses, older age, female sex, underweight, and presence of comorbidities including rheumatoid arthritis, DM, cancer, and CRF were associated with an increased risk of anemia. Conclusions This study revealed that age, female sex, underweight, and the presence of comorbidities such as rheumatoid arthritis, DM, cancer, and CRF were associated with an increased risk of anemia in older Korean adults. Further study on causal relationships between anemia and other variables in the older population is necessary.

show abstract

Section: Introductionmentioning

confidence: 99%

High anemia prevalence in Korean older adults, an advent healthcare problem: 2007–2016 KNHANES

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Anemia in the older population has been reported to be related to various medical burdens, including increased morbidity and mortality [7]. In particular, anemia has been reported to be related to higher cardiovascular events [8,9], frailty [3,10,11], fractures [12], prolonged hospital stay and unfavorable outcomes [13][14][15]. Robins et al, showed that anemia in older population possess potential morbidity and mortality by affecting tissue oxygen delivery, accompany to aging process, and eventually lead multiple major and minor organ dysfunctioning, which include physical and mental function [16].…”

Section: Introductionmentioning

confidence: 99%

High Anemia Prevalence in Korean Older Adults, an Advent Healthcare Problem: 2007-2016 KNHANES

Chueh

Jung

Shim

et al. 2020

Preprint

View full text Add to dashboard Cite

BACKGROUND: Anemia is associated with high morbidity and mortality in older people. However, anemia in older individuals is not fully understood, and national data on the prevalence and characteristics of anemia in Korean older people are lacking. This study aimed to evaluate the prevalence and characteristics of anemia in older adults using data from the Korea National Health and Nutrition Examination Survey (KNHANES), which is the nation-wide cross-sectional epidemiological study conducted by Korean Ministry of Health and Welfare.Methods: Data from the total of 62,825 participants of the 2007-2016 KNHANES were merged and analyzed to investigate differences in participant characteristics and potential risk factors for anemia. Differences in participant characteristics were compared across subgroups using the chi-squared test for categorical variables and independent t-test for continuous variables. Univariate and multivariate analyses using logistic regression were performed to identify related clinical factors.RESULTS: The prevalence of anemia was higher in the population aged ≥65 years than in the younger population. Anemia was also more prevalent among females than among males, but the difference was not statistically significant in people aged >85 years. Being underweight, receiving a social allowance, living alone, and having comorbidities such as hypertension, rheumatoid arthritis, diabetes mellitus (DM), cancer, and chronic renal failure (CRF) were more prevalent in older adults with anemia than in the group without anemia. In the univariate and multivariate analyses, older age, female sex, underweight, and comorbidities including rheumatoid arthritis, DM, cancer, and CRF were associated with an increased risk of anemia. CONCLUSIONS: This study revealed that age, female sex, underweight, and the presence of comorbidities such as rheumatoid arthritis, DM, cancer, and CRF were associated with an increased risk of anemia in Korean older adults. Further study on causal relationships between anemia and other variables in the older population is necessary.

show abstract

“…Recently, the recommended transfusion threshold (7 g/dL) in very old patients has been questioned, and data may indicate that this threshold is too low. 70…”

Section: How To Organize Care?mentioning

confidence: 99%

Elderly Patients in the Intensive Care Unit

Beil

Guidet

2020

Semin Respir Crit Care Med

View full text Add to dashboard Cite

Very old intensive care unit (ICU) patients, aged ≥ 80 years, are by no mean newcomers, but during the last decades their impact on ICU admissions has grown in parallel with the increase in the number of elderly persons in the community. Hence, from being a “rarity,” they have now become common and constitute one of the largest subgroups within intensive care, and may easily be the largest group in 20 years and make up 30 to 40% of all ICU admissions. Obviously, they are not admitted because they are old but because they are with various diseases and problems like any other ICU patient. However, their age and the presence of common geriatric syndromes such as frailty, cognitive decline, reduced activity of daily life, and several comorbid conditions makes this group particularly challenging, with a high mortality rate. In this review, we will highlight aspects of current and future epidemiology and current knowledge on outcomes, and describe the effects of the aforementioned geriatric syndromes. The major challenge for the coming decades will be the question of whom to treat and the quest for better triage criteria not based on age alone. Challenges with the level of care during the ICU stay will also be discussed. A stronger relationship with geriatricians should be promoted to create a better and more holistic care and aftercare for survivors.

show abstract

Impacts of Aging on Anemia Tolerance, Transfusion Thresholds, and Patient Blood Management

Cited by 30 publications

References 51 publications

High anemia prevalence in Korean older adults, an advent healthcare problem: 2007–2016 KNHANES

High anemia prevalence in Korean older adults, an advent healthcare problem: 2007–2016 KNHANES

High Anemia Prevalence in Korean Older Adults, an Advent Healthcare Problem: 2007-2016 KNHANES

Elderly Patients in the Intensive Care Unit

Contact Info

Product

Resources

About