Impacts of ascorbic acid and thiamine supplementation at different concentrations on lead toxicity in testis

Wang, Chunhong; Zhang, Yan; Liang, Jian; Shan, Guang; Wang, Yan; Shi, Qun

doi:10.1016/j.cca.2006.01.023

Cited by 53 publications

(39 citation statements)

References 21 publications

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“…The concentration of Cd and duration of exposure followed a previous study (Thijssen et al 2007). As previously report in lead-intoxicated mice, the concentration of ascorbic acid used in this study appears to be non-toxic to a small rodent animal, like mouse (Wang et al 2006). …”

Section: Animal Treatmentsupporting

confidence: 50%

Protective effect of ascorbic acid on cadmium-induced hypertension and vascular dysfunction in mice

et al. 2010

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Cadmium (Cd) is one of the most important environmental pollutants that cause a number of adverse health effects in humans and animals. Recent studies have shown that Cd-induced oxidative damage within the vascular tissues results in vascular dysfunction. The current study was aimed to investigate whether ascorbic acid could protect against Cd-induced vascular dysfunction in mice. Male ICR mice were received CdCl(2) (100 mg/l) via drinking water for 8 weeks alone or received ascorbic acid supplementation at doses of 50 and 100 mg/kg/day for every other day. Results showed that Cd administration increased arterial blood pressure and blunted the vascular responses to vasoactive agents. These alterations were related to increased superoxide production in thoracic aorta, increased urinary nitrate/nitrite, increased plasma protein carbonyl, elevated malondialdehyde (MDA) concentrations in plasma and tissues, decreased blood glutathione (GSH), and increased Cd contents in blood and tissues. Ascorbic acid dose-dependently normalized the blood pressure, improved vascular reactivities to acetylcholine (ACh), phenylephrine (Phe) and sodium nitroprusside (SNP). These improvements were associated with significant suppression of oxidant formation, prevention of GSH depletion, and partial reduction of Cd contents in blood and tissues. The findings in this study provide the first evidence in pharmacological effects of ascorbic acid on alleviation of oxidative damage and improvement of vascular function in a mouse model of Cd-induced hypertension and vascular dysfunction. Moreover, our study suggests that dietary supplementation of ascorbic acid may provide beneficial effects by reversing the oxidative stress and vascular dysfunction in Cd-induced toxicity.

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Section: Animal Treatmentsupporting

confidence: 50%

Protective effect of ascorbic acid on cadmium-induced hypertension and vascular dysfunction in mice

et al. 2010

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“…Also, diabetic rats were more susceptible to lead nitrate-induced lipid peroxidation than nondiabetic rats in testis tissues. It is evident that lead passes through the bloodtestis barrier and induces testicular damage and then they induce oxidative stress, lipid peroxidation and ROS production that damages the biological membranes in the testes, including degeneration of the spermatogenic and Leydig cells (Wang et al 2006;Sainath et al 2011), like other environmental toxicants (Dirican and Kalender 2012). Lead can accumulate in the reproductive system, which may lead to a reduced number of spermatogenic cells and has been implicated in the oxidative damage in the laboratory animals (Fahim et al 2013;Xiang et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Lead Nitrate Induced Testicular Toxicity in Diabetic and Non-Diabetic Rats: Protective Role of Sodium Selenite

Apaydın

Kalender

Baş

et al. 2014

Braz. arch. biol. technol.

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“…Low lead exposure could alter human semen quality and sperm chromatin condensation [3] . Considerable evidence exists that toxic effects of lead have been demonstrated to be closely associated with relatively high rate of apoptosis [4] . Adhikari et al [1] also reported that Pb could induce apoptosis in the germ cells within the semineferous tubules.…”

Section: The Protective Effect Of Ascorbic Acid and Thiamine Supplemementioning

confidence: 99%

The protective effect of ascorbic acid and thiamine supplementation against damage caused by lead in the testes of mice

Shan

Tang

Zhang

2009

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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Lead is a ubiquitous environmental and industrial pollutant that may have toxic effects on the male. Vitamins may protect against toxic effects of lead in the liver and reproductive system, which is confirmed by our initial research. The aim of this study was to further investigate the protective effects of vitamins (ascorbic acid combined with thiamine) on lead acetate (Pb)-induced reproductive toxicities in mice and study the possible mechanisms underlying these effects. Forty-five male mice were randomly divided into 3 groups, 15 mice in each and received daily intragastric administration with control, Pb (20 mg/kg), and Pb+vitamins (ascorbic acid of 420 mg/kg+thiamine of 30 mg/kg) for 6 weeks, respectively. The Pb-treated animals showed significant decreases in the epididymal sperm count and motility compared to the control group, while the Pb+vitamins group had significant increases for these variables. Moreover, an increasing apoptosis of germinal cells induced by Pb was reduced by vitamin treatment. Pb induced the activation of Caspase-3, Fas/Fas-L and Bcl-2 with elevated levels, and the adaptor protein primarily regulated signaling through Fas and required for Fas-induced apoptosis. In conclusion, ascorbic acid combined with thiamine exhibited protective effect on reproductive system by inhibiting Pb-induced excessive cell apoptosis.

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Impacts of ascorbic acid and thiamine supplementation at different concentrations on lead toxicity in testis

Cited by 53 publications

References 21 publications

Protective effect of ascorbic acid on cadmium-induced hypertension and vascular dysfunction in mice

Protective effect of ascorbic acid on cadmium-induced hypertension and vascular dysfunction in mice

Lead Nitrate Induced Testicular Toxicity in Diabetic and Non-Diabetic Rats: Protective Role of Sodium Selenite

The protective effect of ascorbic acid and thiamine supplementation against damage caused by lead in the testes of mice

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