This study investigates the temporal impacts of climate change on rice yield for summer-autumn (SA) and autumn-winter (AW) cropping pattern along with implication of brackish irrigation water for the SA season. Furthermore, evaluation of different agro-adaptations to overcome negative impacts of climate change was also done for Ca Mau province of Vietnam. Climatic variables were derived from six general circulation models which were further bias corrected at Ca Mau city station for three future time periods (2025s, 2055s, and 2085s). Calibrated AquaCrop 4.0 was used to project the future rice yield under climate change and different salinity levels in irrigation water. Simulation shows a decline in rice yield ranging from 1.60 to 23.69 % and 8.06 to 20.15 % by 2085s relative to baseline climate for A2 and B2 scenarios respectively in the case of the SA cropping season. However, an increase in rice yield ranging from 3.29 to 12.35 % and 6.64 to 17.23 % is observed for the corresponding time period and scenarios. Further simulations for the SA cropping season under climate change and increasing salinity in irrigation water suggest an insignificant increase in yield relative to the yield obtained without irrigation. Moreover, proper management practices, namely forward and early shifts in transplanting dates along with increasing fertilizer application rates, are observed to be beneficial to enhance the rice yield under climate change.