The COVID-19 epidemic has had a significant impact on society. In particular, it has had a strong impact on college students, including international students. Through an online questionnaire survey, it is found that the psychological distress experienced by international students is the result of a combination of the external environment (including the lockdown measures, social distancing, and social support) and internal factors such as values and behavior. The analysis shows that the new teaching mode and the corresponding changes in learning behavior are significantly associated with the psychological distress brought about by the COVID-19 epidemic. In addition, the influence of international students’ values also plays a significant role in their psychological distress. Collective values are conducive to the alleviation of psychological distress, while individual values have the opposite effect. At the same time, the study also reveals that if there is sufficient social support, isolation (due to lockdown or social distancing early or later on) is not necessarily directly related to psychological distress. However, only formal social support can effectively alleviate psychological distress, while informal social support does not play a similar role. These conclusions have certain policy significance for the prevention of and response to epidemics in other countries.