Impacts of endocrine disrupting chemicals on reproduction in wildlife and humans

Marlatt, Vicki L.; Bayen, Stéphane; Castañeda-Cortés, Diana C; Delbès, Géraldine; Grigorova, Petya; Langlois, Valérie S.; Martyniuk, Christopher J.; Metcalfe, Chris D.; Parent, Lise; Rwigemera, Arlette; Thomson, Paisley; Kraak, Glen Van Der

doi:10.1016/j.envres.2021.112584

Cited by 146 publications

(52 citation statements)

References 308 publications

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“…These harmful factors affect the reproductive system of adult men and pregnant women, causing developmental toxicity in themselves and their offspring (36). According to studies, pyrethroid ester pesticides may be endocrine disruptors (37), which can impair the endocrine function of animals and have estrogenic effects on the environment (38). Toxic substances can kill embryos prior to and after implantation, or malformations of various organs (39).…”

Section: Reproductive and Developmental Toxicitymentioning

confidence: 99%

Toxicity and Health Hazards of Pyrethroid Pesticides

Rah

Rustika

2022

Sci Insights

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Worldwide, pyrethroid pesticides have been widely used in the control of agricultural pests and indoor pesticides, so they have an important impact on human daily life. The acute toxicity studies of pyrethroid pesticides have gotten many achievements and progress, but there is still no clear demonstration of its long-term chronic effects. This review presented the collection of published experiments, population surveys and laboratory tests on the long-term and chronic effects of pyrethroid pesticides. Typical research papers, and screened out the research progress in neurotoxicity, reproductive developmental toxicity, immunotoxicity and tumor research of pyrethroid pesticides. It can provide reference ideas for further research and development of harmless pesticides and pesticides.

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Section: Reproductive and Developmental Toxicitymentioning

confidence: 99%

Toxicity and Health Hazards of Pyrethroid Pesticides

Rah

Rustika

2022

Sci Insights

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“…In human beings, pesticides cause health problems while in animals also, various disease conditions like cancer, immunosuppression ( Nicolopoulou-Stamati et al, 2016 ), birth defects, hepatic and nephrotoxicity ( Choudhary et al, 2018 ) have been reported in the farm as well as in wild animals. As pesticides target the endocrine system, several reproductive and fertility problems have been encountered in farm animals ( Marlatt et al, 2022 ). Pesticides not only affect the female reproductive system ( Ramakrishna et al, 2022 ) but also are detrimental to the male reproductive system, causing toxicity to the sperm plasma membrane ( Torres-Badia et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Insights into the recent advances in nano-bioremediation of pesticides from the contaminated soil

Singh

Saxena²

2022

Front. Microbiol.

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In the present scenario, the uncontrolled and irrational use of pesticides is affecting the environment, agriculture and livelihood worldwide. The excessive application of pesticides for better production of crops and to maintain sufficient food production is leading to cause many serious environmental issues such as soil pollution, water pollution and also affecting the food chain. The efficient management of pesticide use and remediation of pesticide-contaminated soil is one of the most significant challenges to overcome. The efficiency of the current methods of biodegradation of pesticides using different microbes and enzymes depends on the various physical and chemical conditions of the soil and they have certain limitations. Hence, a novel strategy is the need of the hour to safeguard the ecosystem from the serious environmental hazard. In recent years, the application of nanomaterials has drawn attention in many areas due to their unique properties of small size and increased surface area. Nanotechnology is considered to be a promising and effective technology in various bioremediation processes and provides many significant benefits for improving the environmental technologies using nanomaterials with efficient performance. The present article focuses on and discusses the role, application and importance of nano-bioremediation of pesticides and toxic pollutants to explore the potential of nanomaterials in the bioremediation of hazardous compounds from the environment.

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“…Evidence is growing that early exposures to endocrine disrupting chemicals (EDCs) can have long term repercussions on reproductive function in mammals, including humans ( Mann et al, 2020 ; Marlatt et al, 2021 ; Delbes et al, 2022 ). These chemical contaminants, of both man-made and natural origin, can affect endogenous hormonal pathways by disrupting hormone production or signalling.…”

Section: Introductionmentioning

confidence: 99%

Impact of in Utero Rat Exposure to 17Alpha-Ethinylestradiol or Genistein on Testicular Development and Germ Cell Gene Expression

2022

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Although the decline in male fertility is believed to partially result from environmental exposures to xenoestrogens during critical developmental windows, the underlying mechanisms are still poorly understood. Experimental in utero exposures in rodents have demonstrated the negative impact of xenoestrogens on reproductive development, long-term adult reproductive function and offspring health. In addition, transcriptomic studies have demonstrated immediate effects on gene expression in fetal reproductive tissues, However, the immediate molecular effects on the developing germ cells have been poorly investigated. Here, we took advantage of a transgenic rat expressing the green fluorescent protein specifically in germ cells allowing purification of perinatal GFP-positive germ cells. Timed-pregnant rats were exposed to ethinylestradiol (EE2, 2 μg/kg/d), genistein (GE, 10 mg/kg/d) or vehicle by gavage, from gestational days (GD) 13–19; testes were sampled at GD20 or post-natal (PND) 5 for histological analysis and sorting of GFP-positive cells. While EE2-exposed females gained less weight during treatment compared to controls, neither treatment affected the number of pups per litter, sex ratio, anogenital distance, or body and gonadal weights of the offspring. Although GE significantly decreased circulating testosterone at GD20, no change was observed in either testicular histology or germ cell and sertoli cell densities. Gene expression was assessed in GFP-positive cells using Affymetrix Rat Gene 2.0 ST microarrays. Analysis of differentially expressed genes (DEGs) (p < 0.05; fold change 1.5) identified expression changes of 149 and 128 transcripts by EE2 and GE respectively at GD20, and 287 and 207 transcripts at PND5, revealing an increased effect after the end of treatment. Only about 1% of DEGs were common to both stages for each treatment. Functional analysis of coding DEG revealed an overrepresentation of olfactory transduction in all groups. In parallel, many non-coding RNAs were affected by both treatments, the most represented being small nucleolar and small nuclear RNAs. Our data suggest that despite no immediate toxic effects, fetal exposure to xenoestrogens can induce subtle immediate changes in germ cell gene expression. Moreover, the increased number of DEGs between GD20 and PND5 suggests an effect of early exposures with latent impact on later germ cell differentiation.

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Impacts of endocrine disrupting chemicals on reproduction in wildlife and humans

Cited by 146 publications

References 308 publications

Toxicity and Health Hazards of Pyrethroid Pesticides

Toxicity and Health Hazards of Pyrethroid Pesticides

Insights into the recent advances in nano-bioremediation of pesticides from the contaminated soil

Impact of in Utero Rat Exposure to 17Alpha-Ethinylestradiol or Genistein on Testicular Development and Germ Cell Gene Expression

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