Impacts of Environmental Insults on Cardiovascular Aging

Yang, Lan; Wu, Shaowei

doi:10.1007/s40572-022-00335-x

Cited by 14 publications

(6 citation statements)

References 150 publications

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“…Measures of arterial stiffness through pulse wave velocity could be also analyzed in relationship with basilar artery characteristics. Further, beyond ethnic differences, cardiovascular risk factors and demographics characteristics considered in this study, environmental factors ( 33 ) and epigenetic changes themselves related to vascular aging ( 34 ) could influence our findings. Strengths of the study include the population-based tri-ethnic sample from a community with publicly-funded universal access to healthcare, and use of systematic deep phenotyping to characterize both vasculature and brain damage.…”

Section: Discussionmentioning

confidence: 92%

Accelerated vascular aging: Ethnic differences in basilar artery length and diameter, and its association with cardiovascular risk factors and cerebral small vessel disease

Sudre

Moriconi

Rehwald

et al. 2022

Front. Cardiovasc. Med.

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Background and aimsRisk of stroke and dementia is markedly higher in people of South Asian and African Caribbean descent than white Europeans in the UK. This is unexplained by cardiovascular risk factors (CVRF). We hypothesized this might indicate accelerated early vascular aging (EVA) and that EVA might account for stronger associations between cerebral large artery characteristics and markers of small vessel disease.Methods360 participants in a tri-ethnic population-based study (120 per ethnic group) underwent cerebral and vertebral MRI. Length and median diameter of the basilar artery (BA) were derived from Time of Flight images, while white matter hyperintensities (WMH) volumes were obtained from T1 and FLAIR images. Associations between BA characteristics and CVRF were assessed using multivariable linear regression. Partial correlation coefficients between WMH load and BA characteristics were calculated after adjustment for CVRF and other potential confounders.ResultsBA diameter was strongly associated with age in South Asians (+11.3 μm/year 95% CI = [3.05; 19.62]; p = 0.008), with unconvincing relationships in African Caribbeans (3.4 μm/year [−5.26, 12.12]; p = 0.436) or Europeans (2.6 μm/year [−5.75, 10.87]; p = 0.543). BA length was associated with age in South Asians (+0.34 mm/year [0.02; 0.65]; p = 0.037) and African Caribbeans (+0.39 mm/year [0.12; 0.65]; p = 0.005) but not Europeans (+0.08 mm/year [−0.26; 0.41]; p = 0.653). BA diameter (rho = 0.210; p = 0.022) and length (rho = 0.261; p = 0.004) were associated with frontal WMH load in South Asians (persisting after multivariable adjustment for CVRF).ConclusionsCompared with Europeans, the basilar artery undergoes more accelerated EVA in South Asians and in African Caribbeans, albeit to a lesser extent. Such EVA may contribute to the higher burden of CSVD observed in South Asians and excess risk of stroke, vascular cognitive impairment and dementia observed in these ethnic groups.

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Section: Discussionmentioning

confidence: 92%

Accelerated vascular aging: Ethnic differences in basilar artery length and diameter, and its association with cardiovascular risk factors and cerebral small vessel disease

Sudre

Moriconi

Rehwald

et al. 2022

Front. Cardiovasc. Med.

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“…The resulting systemic low-level inflammatory response leads to the upregulation of endothelial cell activation and adhesion molecules, which together with white blood cells participate in the formation of atherosclerotic plaques, resulting in adverse health outcomes [ 76 ]. The progression of atherosclerosis and the rupture of plaque are the mechanisms underlying the relationship between particulate air pollution and cardiovascular diseases [ 7 , 77 ]. Endothelial cell activation leads to an increased expression of adhesion molecules and inflammatory genes, a fundamental process in the development of atherosclerosis [ 42 , 66 , 67 , 71 , 78 , 79 , 80 ].…”

Section: Discussionmentioning

confidence: 99%

“…If a disagreement appeared over the review, the disagreement was resolved via preliminary discussion between the two investigators, and a decision was made by a third investigator (S. Wu). We extracted the study data and characteristics of all included studies, including the following: (1) citation information (title, author, journal and year of publication), (2) study period, (3) study location, (4) participant characteristics (amount, age, the ratio of female, disease status), (5) study design, (6) the concentration of exposure (PM 2.5, PM 10 ), (7) the concentration of biomarkers (ET-1, Eselectin, ICAM-1, VCAM-1), ( 8) measurement methodology of exposure, and (9) effect estimates, a unit of the effect estimates and 95% confidence intervals (CIs). For articles lacking data that could be directly extracted, we contacted the corresponding author of the article to obtain data.…”

Section: Data Extractionmentioning

confidence: 99%

“…Even low concentrations of PM 2.5 (below the European limit value of 25 μg/m 3 ) have been associated with a 13% increase in non-fatal acute coronary events [ 5 ]. There is consistent evidence that both short- and long-term exposures to particulate air pollution are associated with cardiovascular disease morbidity and mortality [ 2 , 6 , 7 ]. Cardiovascular disease is responsible for more than two-thirds of fatal illnesses linked to particulate air pollution [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between Ambient Particulate Air Pollution and Soluble Biomarkers of Endothelial Function: A Meta-Analysis

Wang,

Lei,

et al. 2024

Toxics

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Background: The burden of cardiovascular diseases caused by ambient particulate air pollution is universal. An increasing number of studies have investigated the potential effects of exposure to particulate air pollution on endothelial function, which is one of the important mechanisms for the onset and development of cardiovascular disease. However, no previous study has conducted a summary analysis of the potential effects of particulate air pollution on endothelial function. Objectives: To summarize the evidence for the potential effects of short-term exposure to ambient particulate air pollution on endothelial function based on existing studies. Methods: A systematic literature search on the relationship between ambient particulate air pollution and biomarkers of endothelial function including endothelin-1 (ET-1), E-selectin, intercellular cell adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) was conducted in PubMed, Scopus, EMBASE, and Web of Science up to 20 May 2023. Subsequently, a meta-analysis was conducted using a random effects model. Results: A total of 18 studies were included in this meta-analysis. A 10 μg/m3 increase in short-term exposure to ambient PM2.5 was associated with a 1.55% (95% CI: 0.89%, 2.22%) increase in ICAM-1 and a 1.97% (95% CI: 0.86%, 3.08%) increase in VCAM-1. The associations of ET-1 (0.22%, 95% CI: −4.94%, 5.65%) and E-selectin (3.21%, 95% CI: −0.90% 7.49%) with short-term exposure to ambient PM2.5 were statistically insignificant. Conclusion: Short-term exposure to ambient PM2.5 pollution may significantly increase the levels of typical markers of endothelial function, including ICAM-1 and VCAM-1, suggesting potential endothelial dysfunction following ambient air pollution exposure.

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“…Understanding the impact of this vast array of chemical exposures on aging and age-related diseases is critical for public health. Studies employing environmental epidemiology approaches, including geographical data linkages, have confirmed the significant contribution of exposure to environmental pollutants, including particulate matter in air pollution and occupational exposures, to the shared exposome, influencing longevity, geographic clustering, and the development of various age-related chronic NCDs such as neurodegenerative diseases, cardiovascular diseases, and cancer [11,[13][14][15][16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures

Pandics,

Major,

Fazekas-Pongor

et al. 2023

GeroScience

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The aging population worldwide is facing a significant increase in age-related non-communicable diseases, including cardiovascular and brain pathologies. This comprehensive review paper delves into the impact of the exposome, which encompasses the totality of environmental exposures, on unhealthy aging. It explores how environmental factors contribute to the acceleration of aging processes, increase biological age, and facilitate the development and progression of a wide range of age-associated diseases. The impact of environmental factors on cognitive health and the development of chronic age-related diseases affecting the cardiovascular system and central nervous system is discussed, with a specific focus on Alzheimer’s disease, Parkinson’s disease, stroke, small vessel disease, and vascular cognitive impairment (VCI). Aging is a major risk factor for these diseases. Their pathogenesis involves cellular and molecular mechanisms of aging such as increased oxidative stress, impaired mitochondrial function, DNA damage, and inflammation and is influenced by environmental factors. Environmental toxicants, including ambient particulate matter, pesticides, heavy metals, and organic solvents, have been identified as significant contributors to cardiovascular and brain aging disorders. These toxicants can inflict both macro- and microvascular damage and many of them can also cross the blood–brain barrier, inducing neurotoxic effects, neuroinflammation, and neuronal dysfunction. In conclusion, environmental factors play a critical role in modulating cardiovascular and brain aging. A deeper understanding of how environmental toxicants exacerbate aging processes and contribute to the pathogenesis of neurodegenerative diseases, VCI, and dementia is crucial for the development of preventive strategies and interventions to promote cardiovascular, cerebrovascular, and brain health. By mitigating exposure to harmful environmental factors and promoting healthy aging, we can strive to reduce the burden of age-related cardiovascular and brain pathologies in the aging population.

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Impacts of Environmental Insults on Cardiovascular Aging

Cited by 14 publications

References 150 publications

Accelerated vascular aging: Ethnic differences in basilar artery length and diameter, and its association with cardiovascular risk factors and cerebral small vessel disease

Accelerated vascular aging: Ethnic differences in basilar artery length and diameter, and its association with cardiovascular risk factors and cerebral small vessel disease

Association between Ambient Particulate Air Pollution and Soluble Biomarkers of Endothelial Function: A Meta-Analysis

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures

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