We consider the effects of quantum dot radius, confinement potential depth and controllable effective mass on the optical rectification coefficient (ORC) in spherical quantum dots, which is confined with Modified Kratzer-Coulomb Potential (MKCP). Using Nikiforov-Uvarov (N-U) method and compact density matrix theory, the ground state energy, optical rectification coefficient and wave function of electrons under the combined action of many factors are calculated. The results show that they affect the optical rectification response from different angles, including the position of peak and formant.