Impacts of feeding peroxidized oils on growth and oxidative status in swine and poultry

Lindblom, S. C.

doi:10.31274/etd-180810-4976

Cited by 4 publications

(4 citation statements)

References 59 publications

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“…In this study, ω3 enriched diet did not influence lipid peroxidation of sow plasma. It might be that the malondialdehyde measured in the TBARS test was absorbed quickly in the liver before being eliminated in urine without influencing TBARS levels in blood circulation [53]. Here, we observed that FRAP values of LR sows were similar at the end of gestation and tended to increase at the beginning of lactation, compared with CR sows.…”

Section: Discussionmentioning

confidence: 48%

Effects of Low ω6:ω3 Ratio in Sow Diet and Seaweed Supplement in Piglet Diet on Performance, Colostrum and Milk Fatty Acid Profiles, and Oxidative Status

Nguyen

Agazzi

Comi³

et al. 2020

Animals

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The ratio of omega-6 (ω6) to omega-3 (ω3) polyunsaturated fatty acids (PUFAs) in the diet contributes to animal health and performance modulations because they have mostly opposite physiological functions. Increasing ω3 PUFAs content in the maternal diet can stimulate antioxidative capacity in sow and piglets; however, the optimal ratio of ω6 and ω3 PUFAs in the sow diet is still under discussion. Rich sources of bioactive constituents such as brown seaweed are an excellent supplementation to promote animal health and antioxidant status. However, the knowledge of the effects of this compound, specifically in post-weaning piglets, is still limited. Moreover, the combined effect of a low ω6:ω3 PUFAs ratio in sow diet and seaweed supplementation in post-weaning piglets’ diet has never been studied. This research aims to assess the combined effect of a low ω6:ω3 ratio in sow diets and seaweed supplementation in piglet diets on their growth and oxidative status. We also assessed the impact of a low ω6:ω3 ratio in the maternal diet on reproduction, milk fatty acid (FA) profile, and plasma leptin concentration. Two sow diets (n = 8 each) contained either a control ratio (CR, 13:1 during gestation, starting from day 28 (G28) and 10:1 during lactation) or a low ratio (LR, 4:1 from G28 until the end of lactation (L-End)) of ω6:ω3 FA by adding soybean oil or linseed oil, respectively. Reproductive performance was evaluated. Colostrum and milk at lactation day 7 (L7) and L-End were collected to analyze FA profile. Plasma was collected at G28, G79, G108, L7, L14, and L-End for determination of leptin and oxidative status. At weaning, 20 male piglets were selected per sow group to form 4 diet treatments (n = 10 each), which were supplemented with or without 4 g/kg seaweed. Recording of growth performance and collection of blood were performed at days 0, 7, 15, and 21 of post-weaning for oxidative status. LR diet increased (p < 0.05) the survival rate of piglets at weaning, and individual and litter weight gains. Colostrum and milk at L7 and L-End had lower (p < 0.05) ω6:ω3 ratio in LR sows. Interaction between dietary treatments on sows and piglets was revealed for all examined growth parameters at most time points (p < 0.05). LR diet did not affect plasma leptin levels and oxidative status. These findings suggest that the seaweed supplement during post-weaning could not improve growth rate and oxidative status of piglets born from mothers receiving a low dietary ω6:ω3 ratio (4:1) during gestation and lactation. However, this low ratio was beneficial for weaning survival rate, sucking piglets’ weight gain, and ω3 enrichment in colostrum and milk.

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Section: Discussionmentioning

confidence: 48%

Effects of Low ω6:ω3 Ratio in Sow Diet and Seaweed Supplement in Piglet Diet on Performance, Colostrum and Milk Fatty Acid Profiles, and Oxidative Status

Nguyen

Agazzi

Comi³

et al. 2020

Animals

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“…Storage of the oils inevitably results in lipid peroxidation, while consuming diets including peroxidized lipids leads to an impair-ment of body health. [27] Recently, natural products have been extensively performed to improve metabolism and health. Puerarin is a natural isoflavonoid and has been noted to have outstanding anti-inflammatory properties and strong antioxidant activities.…”

Section: Discussionmentioning

confidence: 99%

Puerarin Alleviates Oxidized Oil‐Induced Oxidative Injury and Inflammation via Inhibition of the Nrf2/Keap1 and HMGB1/TLR4/MAPK Signaling Pathways: An Investigation in a Chicken Model

Zhou,

Shi,

et al. 2023

Molecular Nutrition Food Res

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ScopePuerarin has possessed a wide range of pharmacological activities. However, little is known about the protective effects of puerarin on the oxidized oil‐induced injury. Here, the antioxidant and anti‐inflammatory effects of puerarin are described using a chicken model.Methods and resultsA total of 360 broilers are arranged in four treatments. Diets include two types of soybean oil (fresh or oxidized) and two levels of puerarin (0 or 750 mg kg−1). Results show that puerarin alleviates oxidized soybean oil‐induced hepatic and thymic oxidative injury. This effect is observed by increasing the SOD activity and the expressions of Nrf2 signaling pathway‐related genes and reducing the MDA content in the liver and thymus. Moreover, puerarin supplementation decreases the concentrations and mRNA levels of pro‐inflammatory factors in the liver and thymus. The potential mechanism responsible for this is the decrease in the mRNA or protein levels of HMGB1, TLR4, MyD88, and p65 in the liver or thymus. Western blotting results indicate that puerarin also decreases the phosphorylation of JNK1/2, ERK1/2, and p38 in the liver and thymus.ConclusionThis study demonstrates puerarin may be a potential nutrient supplement in the treatment of oxidized oil‐induced damage, and the Nrf2/Keap1 and HMGB1/TLR4/MAPK signaling pathways might be its important target.

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“…Feed preparation and storage of the oils inevitably result in lipid peroxidation, while consuming diets including peroxidized oil leads to a decrease in growth and impairment of host health in poultry (Lindblom, 2017). It has been reported that natural products are extensively performed to promote the growth and health of poultry.…”

Section: Discussionmentioning

confidence: 99%

Dietary puerarin supplementation improves immune function in the small intestines of oxidized oil‐challenged broilers

Zhou,

Yu,

Shi

et al. 2023

Animal Science Journal

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Puerarin has possessed a wide range of pharmacological activities. However, little is known about the protective effects of puerarin on the oxidized oil‐induced injury. Here, we describe the anti‐inflammatory effects of puerarin in chickens. A total of 360 broilers were arranged in four treatments. Diets included two types of soybean oil (fresh or oxidized) and two levels of puerarin (0 or 750 mg/kg). Results showed that puerarin alleviated oxidized soybean oil‐induced intestinal immune injury by decreasing the expressions of HSP and pro‐inflammatory factor (P < 0.05) and enhancing the mRNA levels of anti‐inflammatory factor and CATH‐1 (P < 0.05) in broilers. Moreover, puerarin supplementation decreased the mRNA abundances of TLR4 and MyD88 (P < 0.05) and upregulated the expressions of A20 and SOCS‐1 (P < 0.05) in the small intestine of oxidized soybean oil‐challenged broilers. Collectively, this study demonstrates puerarin may be a potential nutrient supplement in the treatment of oxidized oil‐induced damage in poultry.

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Impacts of feeding peroxidized oils on growth and oxidative status in swine and poultry

Cited by 4 publications

References 59 publications

Effects of Low ω6:ω3 Ratio in Sow Diet and Seaweed Supplement in Piglet Diet on Performance, Colostrum and Milk Fatty Acid Profiles, and Oxidative Status

Effects of Low ω6:ω3 Ratio in Sow Diet and Seaweed Supplement in Piglet Diet on Performance, Colostrum and Milk Fatty Acid Profiles, and Oxidative Status

Puerarin Alleviates Oxidized Oil‐Induced Oxidative Injury and Inflammation via Inhibition of the Nrf2/Keap1 and HMGB1/TLR4/MAPK Signaling Pathways: An Investigation in a Chicken Model

Dietary puerarin supplementation improves immune function in the small intestines of oxidized oil‐challenged broilers

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