2018
DOI: 10.1007/s13205-018-1498-2
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Impacts of horizontal gene transfer on the compact genome of the clavulanic acid-producing Streptomyces strain F613-1

Abstract: Mobile genetic elements involved in mediating horizontal transfer events contribute to bacterial evolution, and bacterial genomic plasticity and instability result in variation in functional genetic information in Streptomyces secondary metabolism. In a previous study, we reported the complete genome sequence of the industrial Streptomyces strain F613-1, which produces high yields of clavulanic acid. In this study, we used comparative genomics and bioinformatics to investigate the unique genomic features of th… Show more

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Cited by 4 publications
(4 citation statements)
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“…In agreement with Li et al (2018), the analysis of the 138 kb genomic region (position 441,384-579,552 of PRJNA360257) with AntiSMASH 3.0 predicted the presence of several secondary metabolite gene clusters, and among them, putative teleocidin biosynthetic genes. The genetic organization of this cluster (Fig.…”
Section: Early S Clavuligerus Atcc 27064 Cultures Produce Teleocidinssupporting
confidence: 63%
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“…In agreement with Li et al (2018), the analysis of the 138 kb genomic region (position 441,384-579,552 of PRJNA360257) with AntiSMASH 3.0 predicted the presence of several secondary metabolite gene clusters, and among them, putative teleocidin biosynthetic genes. The genetic organization of this cluster (Fig.…”
Section: Early S Clavuligerus Atcc 27064 Cultures Produce Teleocidinssupporting
confidence: 63%
“…In addition, at least one of the industrial S. clavuligerus strains for commercial production of CA originating from ATCC 27064, the S. clavuligerus F613-1, holds the genetic potential for production of teleocidins (Cao et al 2016;Li et al 2018). Interestingly, in contrast to contemporary ATCC strains, this industrial producer retained the 138 kb region despite undergoing vast genomic rearrangements, which resulted in more than 1 Mb genome reduction (Li et al 2018). One plausible explanation is that a genetic element within the 138 kb region is complementing for a paralogous function lost through the genome reduction, thereby causing a pressure for preservation of the 138 kb region.…”
Section: Discussionmentioning
confidence: 99%
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“…S. clavuligerus F613-1, an industrial strain for CA production ( 43 , 44 ), was used in this study. Three types of culture medium were used in this study.…”
Section: Methodsmentioning
confidence: 99%