Impacts of Inflammation‐Based Prognostic Scores on Survival in Patients With Hypopharyngeal Squamous Cell Carcinoma

Iuchi, Hiroyuki; Kyutoku, Takayuki; Ito, Kotoko; Matsumoto, Hayato; Ohori, Junichiro; Yamashita, Masaru

doi:10.1177/2473974x20978137

Cited by 7 publications

(13 citation statements)

References 23 publications

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“…Another study also identified a significant association between a high HS-mGPS and a larger tumor size and higher grade of soft tissue sarcoma ( 31 ). A study on hypopharyngeal cancer detected no significant correlation of the GPS with patients’ clinicopathological characteristics ( 49 ). By contrast, we revealed an HS-mGPS of 1−2 to exhibit a significant correlation with advanced-stage disease, more advanced T and N stages, ENE, and a DOI of ≥10 mm, suggesting that the HS-mGPS may have high sensitivity for predicting head and neck cancer aggression.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Role of High-Sensitivity Modified Glasgow Prognostic Score for Patients With Operated Oral Cavity Cancer: A Retrospective Study

et al. 2022

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AimWe probed the prognostic value of the preoperative high-sensitivity modified Glasgow prognostic score (HS-mGPS), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) for patients with oral cavity squamous cell carcinoma (OSCC) to identify patients with the highest risk of having poor survival outcomes.Materials and MethodsWe executed a retrospective assessment of the records of 303 patients with OSCC who had been subjected to curative surgery between January 2008 and December 2017. The HS-mGPS was categorized using C-reactive protein and albumin thresholds of 3 mg/L and 35 g/L, respectively. Moreover, receiver operating characteristic curve analyses were executed to find out the optimal PLR and NLR cutoffs. We plotted survival curves and compared them through the use of the Kaplan–Meier method and log-rank test, respectively. Through a Cox proportional hazard model, we identified prognostic variables. We also plotted a nomogram comprising the HS-mGPS and clinicopathological factors and assessed its performance with the concordance index.ResultsThe PLR and NLR cutoffs were 119.34 and 4.51, respectively. We noted an HS-mGPS of 1−2 to be associated with a shorter median overall survival (OS) and disease-fee survival (DFS) compared with an HS-mGPS of 0. Multivariate analysis revealed that an HS-mGPS of 1−2 and an NLR of ≥4.51 were independent risk factors related to poor OS and DFS. The HS-mGPS appeared to have better prognostic effect than did the PLR and NLR, and the combination of the HS-mGPS and NLR appeared to exhibit optimal discriminative ability for OS prognostication. The nomogram based on the HS-mGPS and NLR yielded accurate OS prediction (concordance index = 0.803).ConclusionOur findings suggest that preoperative HS-mGPS is a promising prognostic biomarker of OSCC, and the nomogram comprising the HS-mGPS and NLR provided accurate individualized OSCC survival predictions.

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Section: Discussionmentioning

confidence: 99%

Prognostic Role of High-Sensitivity Modified Glasgow Prognostic Score for Patients With Operated Oral Cavity Cancer: A Retrospective Study

et al. 2022

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“… 12 Several studies have also investigated the association between the mGPS and outcomes among patients with head and neck cancer. Nakayama et al 13 were the first to report the prognostic value of the mGPS in this setting, and Iuchi et al 5 subsequently reported that combining the mGPS and conventional TNM staging provided more accurate prognostication. In addition, Chen et al 14 have reported that the GPS may have prognostic value and guide personalized treatment among patients with metastatic nasopharyngeal carcinoma who received cisplatin-based palliative chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Utility of the High‐Sensitivity Modified Glasgow Prognostic Scores for Oropharyngeal Carcinoma

et al. 2021

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Objective There is increasing evidence that the high-sensitivity modified Glasgow prognostic scores are inflammatory indices that can predict survival for many cancer types. However, there is limited information regarding their prognostic values in cases of head and neck cancer. This study aimed to evaluate whether the high-sensitivity modified Glasgow prognostic scores could predict outcomes among patients with oropharyngeal squamous cell carcinoma (OPC). Study Design Retrospective study. Setting University hospital. Methods We reviewed the records of 106 patients with histologically confirmed OPC between March 2009 and June 2020. The high-sensitivity modified Glasgow prognostic scores were calculated as 0 (C-reactive protein [CRP] concentration: ≤0.3 mg/dL), 1 (CRP concentration >0.3 mg/dL and albumin concentration ≥3.5 mg/dL), or 2 (CRP concentration >0.3 mg/dL and albumin concentration <3.5 mg/dL). Univariate and multivariable Cox proportional hazard analyses were performed for overall survival (OS) and disease-free survival (DFS). Results Forty-four of these patients had human papillomavirus (HPV)–positive OPC, and 62 had HPV-negative OPC, and these populations were analyzed separately. The high-sensitivity modified Glasgow prognostic score was significantly associated with age, performance status, and HPV. On univariate analysis, high-sensitivity modified Glasgow prognostic score showed associations with OS and DFS in both subpopulations. Moreover, on multivariable analysis, the high-sensitivity modified Glasgow prognostic score showed associations with OS and DFS in both subpopulations. Poor performance status predicted OS in both subpopulations. Conclusion We conclude that the high-sensitivity modified Glasgow prognostic score is useful as an independent prognostic factor in OPC.

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“…Nakayama et al were the first to report the prognostic value of the mGPS in this setting, 16 and Iuchi et al subsequently found that combining the mGPS and conventional TNM staging provided more accurate prognostication. 7 In addition, Chen et al noted that the GPS may have prognostic value and guide personalized treatment among patients with metastatic nasopharyngeal carcinoma who received cisplatin-based palliative chemotherapy. 17 The present study revealed that the mGPS was useful for predicting outcomes among patients with HSCC.…”

Section: Discussionmentioning

confidence: 99%

Utility of the Modified and High‐Sensitivity Modified Glasgow Prognostic Scores for Hypopharyngeal Squamous Cell Carcinoma

Iuchi¹,

Ohori²,

Matsuzaki³

et al. 2021

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Objective To determine whether the modified Glasgow prognostic score (mGPS) and high-sensitivity mGPS (HS-mGPS) could predict outcomes among patients with hypopharyngeal squamous cell carcinoma (HSCC). Study Design Retrospective cohort study. Setting Affiliated university hospital. Methods We reviewed the records of 115 patients with histologically confirmed HSCC between March 2007 and December 2019. Univariate and multivariable Cox proportional hazard analyses were performed for overall survival (OS) and disease-free survival (DFS). Results The 5-year OS rates were 84.0% for the mGPS0 group, 47.8% for the mGPS1 group, and 17.9% for the mGPS2 group ( P < .0001), while the 5-year OS rates were 86.7% for the HS-mGPS0 group, 69.0% for the HS-mGPS1 group, and 22.2% for the HS-mGPS2 group ( P < .001). The mGPS and HS-mGPS were both associated with OS in the univariate analyses, although only the HS-mGPS was independently associated with OS (hazard ratio, 2.68 [95% CI, 1.19-6.05]; P < .05). The 5-year DFS rates were 75.8% for the mGPS0 group, 53.0% for the mGPS1 group, and 13.8% for the mGPS2 group ( P < .001), while the 5-year DFS rates were 79.8% for the HS-mGPS0 group, 56.8% for the HS-mGPS1 group, and 11.6% for the HS-mGPS2 group ( P < .001). The mGPS and HS-mGPS were both associated with DFS in the univariate analyses, although only the HS-mGPS was independently associated with DFS (hazard ratio, 2.35 [95% CI, 1.03-5.37]; P < .05). Conclusion Our study suggests that the HS-mGPS is useful as prognostic factor in HSCC.

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Impacts of Inflammation‐Based Prognostic Scores on Survival in Patients With Hypopharyngeal Squamous Cell Carcinoma

Cited by 7 publications

References 23 publications

Prognostic Role of High-Sensitivity Modified Glasgow Prognostic Score for Patients With Operated Oral Cavity Cancer: A Retrospective Study

Prognostic Role of High-Sensitivity Modified Glasgow Prognostic Score for Patients With Operated Oral Cavity Cancer: A Retrospective Study

Utility of the High‐Sensitivity Modified Glasgow Prognostic Scores for Oropharyngeal Carcinoma

Utility of the Modified and High‐Sensitivity Modified Glasgow Prognostic Scores for Hypopharyngeal Squamous Cell Carcinoma

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