Migration to and sedentarization in the sub-humid zone of Burkina Faso has become a major adaptation measure of Sahelian pastoralists to the severe droughts and in response to a rapidly changing socioeconomic environment. This study is aimed at assessing livelihoods and livestock husbandry practices as a consequence of pastoralist sedentarization. The study sites were located in the Sudano-Sahelian and Sudanian zone of Burkina Faso. Findings revealed that severe Sahelian droughts of 1973/4 and 1983/4 led to massive migration and sedentarization of Sahelian pastoralists to their current locations in the sub humid zones. Since then, the sedentarized pastoralists have diversified their livelihood strategies in which livestock keeping and small-scale crop production play a central role. As the study sites are close to urban areas, a market-oriented local dairy production has also been developing. Overall, the total annual revenue of the sedentarized households and the size of their cattle herd have increased in tandem with the time they have been sedentarized. However, there are still some constraints and challenges such as restricted access to valuable pasture areas during the rainy season and recurrent herder-farmer conflicts that need to be addressed to strengthen the livelihoods of the sedentarized pastoralists.