Impacts of microbiota and its metabolites through gut-brain axis on pathophysiology of major depressive disorder

Chen, Cong-Ya; Wang, Yu-Fei; Lei, Lan; Zhang, Yi

doi:10.1016/j.lfs.2024.122815

Cited by 10 publications

(1 citation statement)

References 189 publications

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“…Patients with inflammatory bowel disease often experience depression, which is indicated by various markers of leaky gut such as calprotectin and LBP [41]. There have been studies conducted on MDD and CFS that have found evidence of gut dysbiosis endotypes, which suggest an association with increased gut permeability and pro-inflammatory potential [42][43][44][45][46].…”

Section: The Paracellular Pathway and Long Covidmentioning

confidence: 99%

From HHV-6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID

Maes,

Almulla,

Tang

et al. 2024

Preprint

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BackgroundInflammation and autoimmune responses contribute to the pathophysiology of Long COVID, and its affective and chronic fatigue syndrome (CFS) symptoms, labeled “the physio-affective phenome.”ObjectivesTo investigate whether Long COVID and its physio-affective phenome are linked to autoimmunity to the tight junction proteins, zonulin and occludin (ZOOC), and immune reactivity to lipopolysaccharides (LPS), and whether the latter are associated with signs of human herpes virus-6 reactivation (HHV-6), autoimmunity directed against oligodendrocyte and neuronal proteins, including myelin basic protein (MBP).MethodsIgA/IgM/IgG responses to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), HHV-6, ZOOC, and neuronal proteins, C-reactive protein (CRP) and advanced oxidation protein products (AOPP), were measured in 90 Long COVID patients and 90 healthy controls. The physio-affective phenome was conceptualized as a factor extracted from physical and affective symptom domains.ResultsNeural network identified IgA directed to LPS (IgA-LPS), IgG-ZOOC, IgG-LPS, and IgA-ZOOC as the most important variables associated with Long COVID diagnosis with an area under the ROC curve of 0.755. Partial Least Squares analysis showed that 40.9% of the variance in the physio-affective phenome was explained by CRP, IgA-MPB and IgG-MBP. A large part of the variances in both autoimmune responses to MBP (36.3-39.7%) was explained by autoimmunity (IgA and IgG) directed to ZOOC. The latter was strongly associated with indicants of HHV-6 reactivation, which in turn was associated with increased IgM-SARS-CoV-2.ConclusionsAutoimmunity against components of the tight junctions and increased bacterial translocation may be involved in the pathophysiology of Long COVID’s physio-affective phenome.

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Section: The Paracellular Pathway and Long Covidmentioning

confidence: 99%

From HHV-6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID

Maes,

Almulla,

Tang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

From human herpes virus‐6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID

Maes,

Almulla,

Tang

et al. 2024

Journal of Medical Virology

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Inflammation and autoimmune responses contribute to the pathophysiology of Long COVID, and its affective and chronic fatigue syndrome symptoms, labeled “the physio‐affective phenome.” To investigate whether Long COVID and its physio‐affective phenome are linked to autoimmunity to the tight junction proteins, zonulin and occludin (ZOOC), and immune reactivity to lipopolysaccharides (LPS), and whether the latter are associated with signs of human herpes virus‐6 (HHV‐6) reactivation, autoimmunity directed against oligodendrocyte and neuronal proteins, including myelin basic protein. IgA/IgM/IgG responses to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), HHV‐6, ZOOC, and neuronal proteins, C‐reactive protein (CRP), and advanced oxidation protein products (AOPPs), were measured in 90 Long COVID patients and 90 healthy controls. The physio‐affective phenome was conceptualized as a factor extracted from physical and affective symptom domains. Neural network identified IgA directed to LPS (IgA‐LPS), IgG‐ZOOC, IgG‐LPS, and IgA‐ZOOC as important variables associated with Long COVID diagnosis with an area under the ROC curve of 0.755. Partial Least Squares analysis showed that 40.9% of the variance in the physio‐affective phenome was explained by CRP, IgA‐myelin basic protein (MBP), and IgG‐MBP. A large part of the variances in both autoimmune responses to MBP (36.3%–39.7%) was explained by autoimmunity (IgA and IgG) directed to ZOOC. The latter was strongly associated with indicants of HHV‐6 reactivation, which in turn was associated with increased IgM‐SARS‐CoV‐2. Autoimmunity against components of the tight junctions and increased bacterial translocation may be involved in the pathophysiology of Long COVID's physio‐affective phenome.

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Circulating B vitamins metabolites in depressive disorders - connections with the microbiota-gut-brain axis

Śliwiński,

Gawlik-Kotelnicka

2024

Behavioural Brain Research

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Impacts of microbiota and its metabolites through gut-brain axis on pathophysiology of major depressive disorder

Cited by 10 publications

References 189 publications

From HHV-6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID

From HHV-6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID

From human herpes virus‐6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID

Circulating B vitamins metabolites in depressive disorders - connections with the microbiota-gut-brain axis

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