2022
DOI: 10.3389/fmicb.2022.868435
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Impacts of Nontuberculous Mycobacteria Isolates in Non-cystic Fibrosis Bronchiectasis: A 16-Year Cohort Study in Taiwan

Abstract: BackgroundThe prevalence of nontuberculous mycobacteria (NTM) in patients with chronic respiratory disease has increased. The implication of NTM in non-CF bronchiectasis remained controversial. This study investigated the impact of NTM in non-CF bronchiectasis in Taiwan.MethodsClinical manifestation, imaging, and microbiological data were retrieved from the Chang Gung Research Database, the largest electronic medical record-based database in Taiwan. Patients with bronchiectasis during 2001–2016 were included. … Show more

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Cited by 9 publications
(3 citation statements)
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“…For the patients with BROS who used bDMARDs, the risks of NTM and tuberculosis were increased. NTM infection is associated with higher rates of respiratory failure and mortality and sometimes with P. aeruginosa or fungal coinfection, causing more frequent exacerbations in patients with bronchiectasis ( 33 , 34 ). The use of bDMARDs should be cautious in patients with BROS to avoid aggravating the vicious cycle of bronchiectasis.…”
Section: Discussionmentioning
confidence: 99%
“…For the patients with BROS who used bDMARDs, the risks of NTM and tuberculosis were increased. NTM infection is associated with higher rates of respiratory failure and mortality and sometimes with P. aeruginosa or fungal coinfection, causing more frequent exacerbations in patients with bronchiectasis ( 33 , 34 ). The use of bDMARDs should be cautious in patients with BROS to avoid aggravating the vicious cycle of bronchiectasis.…”
Section: Discussionmentioning
confidence: 99%
“…Respiratory physiotherapy is an integral part of the daily management of NTM-PD. Persistent detection of NTM in sputum is associated with worse outcomes 29 and physiotherapy interventions have been shown to mitigate this in people with bronchiectasis and CF. 30 , 31 The aims of physiotherapy are to maintain ventilation in all parts of the lungs; postpone progression of pulmonary disease; stimulate establishment and retention of normal physical capacity; and avoid pain and musculoskeletal complications due to pulmonary or bone disease.…”
Section: Managementmentioning
confidence: 99%
“…Non-tuberculous mycobacterium, viral and fungal infections are also less frequently responsible for exacerbations. Irreversible structural remodeling of the airways leads to a vicious cycle of infections which further propels the person toward progressive loss of lung function [6]. Acute and preventive management of infections is therefore pertinent to reducing bronchial inflammation, improving quality of life, and achieving long-term positive outcomes [7,8].…”
Section: Introductionmentioning
confidence: 99%