Potato tuber formation is a complex process that is induced by a mobile signal called tuberigen. It involves several genes such as AtBMI, St 14-3-3s, StBEL, StBELL11, StBELL29, StBMI1-1, StCDF1, StCEN, StCO, StFDL1, StFT, StGA2ox1, StGA3ox2, StMSI1, StSP6A. This article focuses on important factors such as genetic factors, low temperature, high irradiation, low nitrogen, abscisic acid, chlormequat chloride, auxin, Jasmonic acid, cytokinin and paclobutrazol that induce tuber formation while ethylene, drought, low irradiation, high-temperature that reduce or inhibit tuber initiation.