Impacts of restricted feeding and realimentation on bone development and plasma concentrations of bone-specific biomarkers in lambs

Swelum, Ayman A.; Saadeldin, Islam M.; Alowaimer, Abdullah N.; Mahmoud, Ahmed Hossam; Abouheif, M. A.

doi:10.22358/jafs/74008/2017

Cited by 4 publications

(5 citation statements)

References 15 publications

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“…Osteoblast activity in bone creation is indicated by biochemical markers such as osteocalcin and ALP, which are used to monitor bone cell growth and turnover [21] The diseased group's serum osteocalcin levels significantly (P<0.05) decreased compared to those in the control one. This conclusion is consistent with the findings of [22], who found that feed limitation was linked to low levels of P and osteocalcin in lambs, but not with his assertion that there was no discernible change in the Ca level.…”

Section: Discussionsupporting

confidence: 91%

“…Serum Osteocalcin (OC) is one of bone turn over marker in sheep giving an indication about osteoclast cell activity during bone formation [21]. The bone markers osteocalcin and alkaline phosphatase were useful for identifying changes in bone length caused by variations in feed restriction levels in lamb [22]. Vitamin D regulates the homeostasis of calcium.…”

Section: Introductionmentioning

confidence: 99%

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Gene Expression of Oxidative/Antioxidative Markers, VDR, CAMK4 and Ceruloplasmin in Baladi Sheep a with Minerals Deficiency

Emam,

Ghanem,

Abdel-Raof

et al. 2025

Egyptian Journal of Veterinary Sciences

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HE OBJECTIVE of this work was to elaborate gene expression and serum profile of oxidative/antioxidant and bone markers associated with minerals deficiency and their correlation with mineral deficiency in sheep. The study was carried out on 26 selected diseases cases out of survey on 250 sheep suffered from mineral deficiency compared to 10 apparent healthy control sheep based on clinical examination. Biochemically, there was a significant (P<0.05) decline in Ca, P, Mg, Cu, Zn, Se, Fe, TAC, GPx, SOD, CAT, OC and CP, whereas MDA level was significantly increased (P<0.05). Gene expression of SOD, CAT, GPX1, VDR, CAMK4 and ceruloplasmin genes were significantly down-regulated (P<0.05) in diseased sheep. A contrary tendency was evoked by the gene OXSR1.The variability in studied genes alongside alterations in the serum profile of investigated markers could be a reference guide for limiting the mineral deficiency in sheep through prescribing an efficient nutritional management strategy for sheep flocks that includes the essential macro-and micro aspects, and not depend just on grazing as a primary source of feed to sustain sheep health and output.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Gene Expression of Oxidative/Antioxidative Markers, VDR, CAMK4 and Ceruloplasmin in Baladi Sheep a with Minerals Deficiency

Emam,

Ghanem,

Abdel-Raof

et al. 2025

Egyptian Journal of Veterinary Sciences

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“…Literature data concerning influence supply of phosphorus on bone growth are inconclusive. Swelum et al (2017) in the study with lambs shown that similar to our results lower phosphorus and calcium intake diminished femur length. Liesegang et al (2002) has…”

Section: Mass Length and Diameters O The Femursupporting

confidence: 92%

Chemical body composition and bone growth of young pigs as affected by deficiency, adequate and excess of dietary phosphorus supply

Sobol

Skiba

Raj

et al. 2022

Annals of Animal Science

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Objective of the experiment was to study the effect of deficiency, adequate and excess dietary phosphorus supply on growth performance, retention and utilisation of phosphorus, length, mass and geometry measurements of the femur shaft, content of protein, ash, phosphorus in viscera, edible (meat and fat) and inedible (bones and skin) parts of the body in pigs ageing from 33 to 110 days. It was found that compared to animals fed according to phosphorus requirement the deficiency and excess of dietary phosphorus did not influenced o total feed intake (mean 120.6 kg) and feed conversion (mean 1.9 kg/kg gain). However phosphorus deficiency lowered total gain of the body mass (P=0.0072), diminished weight of the inedible part of the carcass (P=0.0229), decreased the content of body protein (P=0.0171), ash (P=0.0001), and phosphorus (P=0.0001). Whereas, over-supply of dietary phosphorus did not cause any change of these component. Utilisation of the total phosphorus was diminished (P=0.0001) in pigs fed diet with both excess (by 16.26%) and deficiency (by 12.28%) of the phosphorus, but excess had much lower negative impact than its' deficiency. When available form of this element was considered over-supply still reduced (P=0.0001) its utilisation the most (by 26.58%) but deficiency made utilisation the best (7.77%). Both dietary deficiency and over-supply of the phosphorus diminished (P=0.0001) femur mass (by 25 and 11 g , respectively). Thus negative impact of phosphorus deficiency was much stronger. Moreover, phosphorus deficiency diminished (P=0.0015) bone length (by 0.5 cm), however, excess did not change this feature. Response of animals to a decrease bone mass and length due disturbances in phosphorus supply (both deficiency and excess) was the increase the vertical external diameter of the femur shaft.

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“…Therefore, the first hypothesis of this experiment was rejected as additional CP alone was unable to increase SER in the absence of an increase in ME intake. These results are supported by many experiments that examined the effect of feed restriction in LWG and change in body dimension (skeletal changes) (Searle et al 1989;Tolla et al 2003;Keogh et al 2015a;Swelum et al 2017). In general, during feed restriction LWG and SER decline with a restriction in ME intake, although the skeletal tissue appears less responsive to nutrient supply than soft tissues and LW.…”

Section: Animal Growth and Developmentmentioning

confidence: 65%

Skeletal growth in cattle in response to nutritional and hormonal manipulation

Antari¹

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Impacts of restricted feeding and realimentation on bone development and plasma concentrations of bone-specific biomarkers in lambs

Cited by 4 publications

References 15 publications

Gene Expression of Oxidative/Antioxidative Markers, VDR, CAMK4 and Ceruloplasmin in Baladi Sheep a with Minerals Deficiency

Gene Expression of Oxidative/Antioxidative Markers, VDR, CAMK4 and Ceruloplasmin in Baladi Sheep a with Minerals Deficiency

Chemical body composition and bone growth of young pigs as affected by deficiency, adequate and excess of dietary phosphorus supply

Skeletal growth in cattle in response to nutritional and hormonal manipulation

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