Impacts of selenium enrichment on nutritive value and obesity prevention of Cordyceps militaris: A nutritional, secondary metabolite, and network pharmacological analysis

Zhu, Zhenjun; Huang, Aohuan; Chen, Mengfei; Wang, Juan; Li, Zeyang; Sun, Zhongxu; Ye, Yiheng; Nan, Jingwei; Yu, Shubo; Chen, Moutong; Xie, Yizhen; Hu, Huiping; Zhang, Jumei; Wu, Qingping; Ding, Yu

doi:10.1016/j.fochx.2023.100788

Cited by 6 publications

(2 citation statements)

References 45 publications

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“…In contrast, orlistat, RMTN, and FBTN supplements significantly inhibited HFD-induced hepatic steatosis and reversed HFD-induced alterations in the gene expression of these genes, which caused inflammatory responses in the livers of the mice. AMPK plays a crucial role in various biological responses, including lipid synthesis and inflammatory regulation, making it essential for maintaining cellular functions [39]. PPAR-α is known to promote fatty acid oxidation and maintain lipid metabolic homeostasis in vivo by reducing the accumulation of lipid droplets in hepatocytes [40].…”

Section: Effect Of Fbtn On the Expression Of Genes Related To Lipid M...mentioning

confidence: 99%

Fu Brick Tea as a Staple Food Supplement Attenuates High Fat Diet Induced Obesity in Mice

Wu,

Zhao,

Guo

et al. 2023

Foods

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Fu brick tea (FBT), a product of microbial fermentation from primary dark tea, also known as raw material tea (RMT), has been extensively studied for its functional properties. However, its potential as a staple food supplement for weight loss remains poorly understood. This study compared the weight loss effects of orlistat, traditional plain noodles (NN), and noodles supplemented with varying amounts of RMT (RMTN) and FBT (FBTN), with the aim to elucidate their lipid-reducing effects and underlying mechanisms. Experimental trials on high fat diet fed mice revealed significant weight loss, lipid-lowering, and hypoglycemic effects upon supplementation with orlistat, RMTN, and FBTN. Moreover, supplementation with orlistat, RMTN, and FBTN effectively restored serum and liver-related index levels, mitigating high-fat diet-induced dyslipidemia. Additionally, these supplements ameliorated liver and kidney damage by inhibiting oxidative stress and inflammatory responses. Furthermore, orlistat, RMTN, and FBTN exert their anti-obesity effects primarily by modulating genes associated with lipid metabolism and inflammatory responses and through regulation of the composition and structure of the gut microbiota. Importantly, FBTN demonstrated a significantly stronger lipid-lowering effect compared to RMTN, particularly at higher tea addition ratios. In contrast, NN supplementation exhibited minimal to no weight loss effects. Based on these findings, it could be inferred that FBT holds promise as a staple food supplement to ameliorate high-fat diet-induced obesity and its associated health conditions.

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Section: Effect Of Fbtn On the Expression Of Genes Related To Lipid M...mentioning

confidence: 99%

Fu Brick Tea as a Staple Food Supplement Attenuates High Fat Diet Induced Obesity in Mice

Wu,

Zhao,

Guo

et al. 2023

Foods

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show abstract

“…It possesses various hygienic and pharmacological properties, including antioxidant, antimicrobial, and antiviral activities, as well as immunomodulatory effects [ 1 , 2 , 3 , 4 ]. Moreover, cordycepin has been proven to inhibit adipose accumulation [ 5 ] and exhibit anti-inflammatory and antiproliferative effects on human cancer cells [ 6 , 7 ]. These characteristics make it a potential candidate for clinical applications in cancer treatment, such as leukemia.…”

Section: Introductionmentioning

confidence: 99%

Improved Cordycepin Production by Cordyceps Militaris Using Corn Steep Liquor Hydrolysate as an Alternative Protein Nitrogen Source

Chang,

Liu,

Jiao

et al. 2024

Foods

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Cordycepin production in the submerged culture of Cordyceps militaris was demonstrated using hydrolyzed corn processing protein by-products, known as corn steep liquor hydrolysate (CSLH), as an alternative nitrogen source. The growth, metabolism, and cordycepin production of Cordyceps militaris were evaluated under various concentrations of CSLH induction. The results demonstrated that CSLH addition had positive effects on the growth and cordycepin production with various C. militaris strains. The optimum strain, C. militaris GDMCC5.270, was found to effectively utilize CSLH to promote mycelium growth and cordycepin production. Low concentrations of CSLH (1.5 g/L) in the fermentation broth resulted in 343.03 ± 15.94 mg/L cordycepin production, which was 4.83 times higher than that of the group without CSLH. This also enhanced the metabolism of sugar, amino acids, and nucleotides, leading to improved cordycepin biosynthesis. The increase in key amino acids, such as glutamic acid, alanine, and aspartic acid, in the corn steep liquor hydrolysate significantly enhanced cordycepin yield. The corn steep liquor hydrolysate was confirmed to be a cost-effective accelerator for mycelium growth and cordycepin accumulation in C. militaris, replacing partial peptone as a cheap nitrogen source. It serves as a suitable alternative for efficient cordycepin production at a low cost.

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Absorption and utilization of polysaccharides from Cordyceps militaris fruiting bodies and their protective effects against CCl4-induced acute liver injury in mice

Lan,

Wang,

Luo

et al. 2024

Food Bioscience

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Impacts of selenium enrichment on nutritive value and obesity prevention of Cordyceps militaris: A nutritional, secondary metabolite, and network pharmacological analysis

Cited by 6 publications

References 45 publications

Fu Brick Tea as a Staple Food Supplement Attenuates High Fat Diet Induced Obesity in Mice

Fu Brick Tea as a Staple Food Supplement Attenuates High Fat Diet Induced Obesity in Mice

Improved Cordycepin Production by Cordyceps Militaris Using Corn Steep Liquor Hydrolysate as an Alternative Protein Nitrogen Source

Absorption and utilization of polysaccharides from Cordyceps militaris fruiting bodies and their protective effects against CCl4-induced acute liver injury in mice

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