Impacts of shift work on sleep and circadian rhythms

Boivin, Diane B.; Boudreau, Philippe

doi:10.1016/j.patbio.2014.08.001

Cited by 409 publications

(300 citation statements)

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“…Studies in humans indicated that the number of circulating T cells is regulated by the central clock via glucocorticoid signaling (18,36). The present study, as well as previous studies, shows that, for most night shift workers, central clock-derived signals, such as melatonin and cortisol rhythms, do not spontaneously shift in response to night shift (39,56). Therefore, we infer that the rhythms of circulating T lymphocytes and monocytes, which were not shifted in response to night shift, might be controlled, at least in part, by the central clock.…”

Section: Discussionsupporting

confidence: 76%

“…We demonstrate that, following night shifts, the relative phase of the rhythms of cytokine secretion and immune cell counts is disturbed, and these two rhythms no longer demonstrate the conventional phase relationship with the sleep-wake cycle and with the external environment. Thus, night shift leads to a disruption of the rhythmicity of the immune system, probably as a consequence of the desynchronization between the central and peripheral clocks, as we described previously when comparing central markers (e.g., cortisol and melatonin rhythms) with peripheral markers (e.g., clock gene expression in PBMCs) (35,39,40). Such a disruption might play a role in the increased incidence of various medical conditions in shift workers, such as the increased risk for infections, autoimmune diseases, cancer, and cardiovascular and metabolic disorders (2,(8)(9)(10)(11)(12)(13).…”

Section: Discussionmentioning

confidence: 83%

“…From studies in humans, sleep, sleep deprivation, sleep restriction, and mistimed sleep appear to affect immune functions, but discrepancies were observed (38). Given the deleterious effects of circadian disruption and insufficient sleep on many biological processes (e.g., endocrine, metabolic, cardiovascular, cognitive), as observed in some shift workers (39), more studies are needed to characterize the effects of such disruption on the functions of the innate and adaptive immune systems. The objective of the current study was to subject individuals to a simulated night shift protocol and to investigate the effects on innate and adaptive immune responses.…”

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confidence: 99%

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Simulated Night Shift Disrupts Circadian Rhythms of Immune Functions in Humans

Cuesta

Boudreau

Dubeau-Laramée

et al. 2016

The Journal of Immunology

112

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Recent research unveiled a circadian regulation of the immune system in rodents, yet little is known about rhythms of immune functions in humans and how they are affected by circadian disruption. In this study, we assessed rhythms of cytokine secretion by immune cells and tested their response to simulated night shifts. PBMCs were collected from nine participants kept in constant posture over 24 h under a day-oriented schedule (baseline) and after 3 d under a night-oriented schedule. Monocytes and T lymphocytes were stimulated with LPS and PHA, respectively. At baseline, a bimodal rhythmic secretion was detected for IL-1β, IL-6, and TNF-α: a night peak was primarily due to a higher responsiveness of monocytes, and a day peak was partly due to a higher proportion of monocytes. A rhythmic release was also observed for IL-2 and IFN-γ, with a nighttime peak due to a higher cell count and responsiveness of T lymphocytes. Following night shifts, with the exception of IL-2, cytokine secretion was still rhythmic but with peak levels phase advanced by 4.5–6 h, whereas the rhythm in monocyte and T lymphocyte numbers was not shifted. This suggests distinct mechanisms of regulation between responsiveness to stimuli and cell numbers of the human immune system. Under a night-oriented schedule, only cytokine release was partly shifted in response to the change in the sleep–wake cycle. This led to a desynchronization of rhythmic immune parameters, which might contribute to the increased risk for infection, autoimmune diseases, cardiovascular and metabolic disorders, and cancer reported in shift workers.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 83%

mentioning

confidence: 99%

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Simulated Night Shift Disrupts Circadian Rhythms of Immune Functions in Humans

Cuesta

Boudreau

Dubeau-Laramée

et al. 2016

The Journal of Immunology

112

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“…The shift workers, especially those who work night shifts, commonly encounter with sleep problems in terms of poor sleep quality and short sleep length (Åkerstedt & Wright, 2009;Boivin & Boudreau, 2014). Several studies suggested that disturbance of circadian rhythm is an important factor affecting the performance of the shift workers (Costa, 2003;Gumenyuk et al, 2014;Hildebrandt & Stratmann, 1979).…”

Section: Introductionmentioning

confidence: 99%

D8-4　Sleepiness and Performance among Oil Rig Onshore Shift Workers in Thailand

Bandidcharoenlert

Bhuanantanondh

Jalayondeja

et al. 2017

The Japanese journal of ergonomics

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Shiftwork is associated with negative impact on workers' performance, safety and health due to circadian rhythms disturbance and sleep deficit. The purpose of this study was to assess performance and sleepiness among Thai oil rig onshore shift workers. Healthy Thai onshore shift workers who work on a 12-hour swing shift in an oil and gas company in Thailand participated in this study. The work cycle started from one week of night shifts followed by one week of day shifts. All participants were asked to rate their sleepiness using the Epworth Sleepiness Scale (ESS) questionnaire at the first visit. Furthermore, the participants performed the finger tapping (FT) test in an android application at the pre-and post-shift at the beginning and end of "Night" and "Day" shift period. For the FT test, each participant was instructed to use the index finger to tap on a response button as fast as possible within a 10-second time interval. The total of 38 male-shift workers with a mean age of 36.1±7.87 years participated in this study. The results showed that the mean ESS score was 8.84±4.03 and 63.2% of the participants had an ESS score in the normal range (ESS = 0-10), 31.6% had mild to moderate degree of sleepiness (ESS = 11-15), and 5.3% had severe degree of sleepiness (ESS > 16). For the "Night" shift period, the mean left FT rates on "Night 1"and "Night 7" of the pre-shift were 60.32±6.21 times/10 seconds and 61.39±7.43 times/10 seconds, respectively and of the post-shift were 56.24±5.43 times/10 seconds and 58.76±6.93 times/10 seconds, respectively. The mean right FT rates on "Night 1 and "Night 7" of the pre-shift were 65.11±6.49 times/10 seconds and 65.79±7.82 times/10 seconds, respectively and of the post-shift were 61.08±7.23 times and 63.5±7.44 times/10 seconds, respectively. The results showed that, for the "Night" shift period, the mean left and right FT rates of the post-shift were significantly less than those of the pre-shift (p < 0.05). For the "Day" shift period, the mean left FT rates on "Day 1" and "Day 8" of the pre-shift were 60.08±6.98 times/10 seconds and 61.03±6.73 times/10 seconds, respectively and of the post-shift were 62±6.54 times/10 seconds and 61.76±6.87 times/10 seconds, respectively. The mean of right FT rates on "Day 1" and "Day 8" of the pre-shift were 64.74±7.94 times/10 seconds and 65.97±7.82 times/10 seconds, respectively and of the post-shift were 65.68±10.35 times/10 seconds and 67.66±8.06 times/10 seconds, respectively. The results showed that in general, for the "Day" shift period, the mean left and right FT rates of the post-shift were significantly greater than those of the pre-shift (p < 0.05). The onshore shift workers revealed poorer performance during the "Night" shift period than the "Day" shift period which might be due to the perturbation of circadian rhythms and sleep loss. It might lead to poor quality of life and higher risk of accident in shift workers. Thus, work scheduling and effective assessment of performance and sleepiness should be of concern to the orga...

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“…It has been reported that shift work is associated with cancer, diabetes, gastrointestinal disorders, metabolic and cardiovascular disease (Knutsson, 2003;Kubo et al, 2006;Lie, Roessink, & Kjaerheim, 2006;Mosendane, Mosendane, & Raal, 2008;Nojkov, Rubenstein, Chey, & Hoogerwerf, 2010;Pan, Schernhammer, Sun, & Hu, 2011;Wang, Armstrong, Cairns, Key, & Travis, 2011), and the proposed underlying mecha-nisms encompass circadian rhythm disruption, light at night, sleep deprivation, immune depression, lifestyle changes and stress (Boivin & Boudreau, 2014;Brondel, Romer, Nougues, Touyarou, & Davenne, 2010;Bushnell, Colombi, Caruso, & Tak, 2010;Crispim et al, 2011;Fritschi et al, 2011;Hansen, 2001). Specifically, in relation to healthcare work, in which non-regular and night work hours are commonly seen, there is evidence, most of it from studies in nurses, about how this type of job organization can affect workers in a negative way, both physiologically and psychologically (Admi, Tzischinsky, Epstein, Herer, & Lavie, 2008).…”

Section: Introductionmentioning

confidence: 99%