Impacts of stimulus parameters and configurations on motor cortex direct electrical stimulation using intrinsic optical imaging: a pilot study

Abstract

Background Motor cortex stimulation applied as a clinical treatment for neuropathic disorders for decades. With stimulation electrodes placed directly on the cortical surface, this neuromodulation method provides higher spatial resolution than other non-invasive therapies. Yet, the therapeutic effects reported were not in conformity with different syndromes. One of the main issues is that the stimulation parameters are always determined by clinical experience. The lack of understanding about how the stimulation current propagates in the cortex and various stimulation parameters and configurations obstruct the development of this method. Methods In this study, we investigated the effect of different stimulation configurations on cortical responses to motor cortical stimulations using intrinsic optical imaging. Results Our results showed that the cortical activation of electrical stimulation is not only related to the current density but also related to the propagation distance. Besides, stimulation configurations also affect the propagation of the stimulation current. Conclusions All these results provide preliminary experimental evidence for parameter and electrode configuration optimizations.

Correction: Impacts of stimulus parameters and configurations on motor cortex direct electrical stimulation using intrinsic optical imaging: a pilot study

“…Following the publication of the original article [ 1 ], the affiliation 1 and 2 need to be swapped and the affiliations should read as follow:…”

Electrochemistry in Action-Engineering the Neuronal Response to Electrical Microstimulation

“…Estimates of the effective electric field spread from these devices generally span from thousands to millions of individual neurons. [1][2][3] Unfortunately, some neurological diseases and injuries require stimulation fields of higher precision. Next-generation microneuromodulation devices (~10 2 -10 3 µm 2 surface area) have been developed by others with hundreds of closely spaced channels.…”