Impacts of Systemic Hypertension and Left Ventricular Hypertrophy on Outcome of Cardiopulmonary Resuscitation and Therapeutic Hypothermia in a Cardiac Arrest Model of Rat

Wang, Pei; Zhang, Lei; Gong, Yushun; Zhang, Hehua; Wang, Xiang; Li, Yongqin

doi:10.1097/shk.0000000000000510

Cited by 7 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ischemic heart disease and diabetes were present in around 30% and 10% in the TTM-trial and the HACA study. The few studies that evaluated animals with comorbidities did not consistently favour TTM [69][70][71][72]. Outcome was evaluated at 6 months in both the TTM-trial and the HACA study, a time point rare in animal studies; only 14 of 481 histological comparisons were made at 6 months or later and no comparisons of neurobehaviour and mortality were made at this time.…”

Section: Stair Analysismentioning

confidence: 99%

Meta-analysis of targeted temperature management in animal models of cardiac arrest

Olai

Thornéus

Watson

et al. 2020

ICMx

View full text Add to dashboard Cite

Background: Targeted temperature management (TTM) of 32 to 34°C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 indicated benefit on survival and neurological outcome. In 2013, a clinical trial showed no difference in outcome between TTM of 33°C and TTM of 36°C. In this meta-analysis, we investigate the evidence for TTM in animal models of cardiac arrest. Methods: We searched PubMed and EMBASE for adult animal studies using TTM as a treatment in different models of cardiac arrest or global brain ischemia which reported neurobehavioural outcome, brain histology or mortality. We used a random effects model to calculate estimates of efficacy and assessed risk of bias using an adapted eight-item version of the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES) quality checklist. We also used a scoring system based on the recommendations of the Stroke Treatment Academic Industry Roundtable (STAIR), to assess the scope of testing in the field. Included studies which investigated a post-ischemic induction of TTM had their treatment regimens characterized with regard to depth, duration and time to treatment and scored against the modified STAIR criteria. Results: The initial and updated search generated 17809 studies after duplicate removal. One hundred eighty-one studies met the inclusion criteria, including data from 1,787, 6,495 and 2,945 animals for neurobehavioural, histological and mortality outcomes, respectively. TTM was favoured compared to control for all outcomes. TTM was beneficial using short and prolonged cooling, deep and moderate temperature reduction, and early and delayed time to treatment. Median [IQR] study quality was 4 [3 to 6]. Eighteen studies checked seven or more of the eight CAMARADES quality items. There was no clear correlation between study quality and efficacy for any outcome. STAIR analysis identified 102 studies investigating post-ischemic induction of TTM, comprising 147 different treatment regimens of TTM. Only 2 and 8 out of 147 regimens investigated comorbid and gyrencephalic animals, respectively.

show abstract

Section: Stair Analysismentioning

confidence: 99%

Meta-analysis of targeted temperature management in animal models of cardiac arrest

Olai

Thornéus

Watson

et al. 2020

ICMx

View full text Add to dashboard Cite

show abstract

“…The diabetes mellitus induced in the present study triggered cardiac hypertrophy irrespective of dietary fortifications. Diabetes in general, and especially type II diabetes, causes hypertension in humans, and this has also been proven in rats [56,57]. Hypertension in turn leads to cardiac hypertrophy [58,59,60].…”

Section: Discussionmentioning

confidence: 99%

Dietary EPA Increases Rat Mortality in Diabetes Mellitus, a Phenomenon Which Is Compensated by Green Tea Extract

Leger

Azarnoush

et al. 2019

Antioxidants

View full text Add to dashboard Cite

Diabetes is characterized by a high mortality rate which is often associated with heart failure. Green tea and eicosapentaenoic acid (EPA) are known to lessen some of the harmful impacts of diabetes and to exert cardio-protection. The aim of the study was to determine the effects of EPA, green tea extract (GTE), and a combination of both on the cardiac consequences of diabetes mellitus, induced in Wistar rats by injection of a low dose of streptozotocin (33 mg/kg) combined with a high fat diet. Cardiac mechanical function, coronary reactivity, and parameters of oxidative stress, inflammation, and energy metabolism were evaluated. In the context of diabetes, GTE alone limited several diabetes-related symptoms such as inflammation. It also slightly improved coronary reactivity and considerably enhanced lipid metabolism. EPA alone caused the rapid death of the animals, but this effect was negated by the addition of GTE in the diet. EPA and GTE combined enhanced coronary reactivity considerably more than GTE alone. In a context of significant oxidative stress such as during diabetes mellitus, EPA enrichment constitutes a risk factor for animal survival. It is essential to associate it with the antioxidants contained in GTE in order to decrease mortality rate and preserve cardiac function.

show abstract

“…Rats aged 2–3 months can generally reach 250–450 g. What we tend to overlook here is that the majority of CA patients are not healthy, they are usually complicated with organic disease. A study of hypertensive CA rats showed that hypertension groups got more severe brain damage and lower survival than the control group ( Wang et al, 2016 ). It reflected differences between healthy CA patients and CA patients with other co-morbidities.…”

Section: Attributes Of Rats For Modeling Acamentioning

confidence: 99%

Rat model of asphyxia-induced cardiac arrest and resuscitation

Zhu

et al. 2023

Front. Neurosci.

View full text Add to dashboard Cite

Neurologic injury after cardiopulmonary resuscitation is the main cause of the low survival rate and poor quality of life among patients who have experienced cardiac arrest. In the United States, as the American Heart Association reported, emergency medical services respond to more than 347,000 adults and more than 7,000 children with out-of-hospital cardiac arrest each year. In-hospital cardiac arrest is estimated to occur in 9.7 per 1,000 adult cardiac arrests and 2.7 pediatric events per 1,000 hospitalizations. Yet the pathophysiological mechanisms of this injury remain unclear. Experimental animal models are valuable for exploring the etiologies and mechanisms of diseases and their interventions. In this review, we summarize how to establish a standardized rat model of asphyxia-induced cardiac arrest. There are four key focal areas: (1) selection of animal species; (2) factors to consider during modeling; (3) intervention management after return of spontaneous circulation; and (4) evaluation of neurologic function. The aim was to simplify a complex animal model, toward clarifying cardiac arrest pathophysiological processes. It also aimed to help standardize model establishment, toward facilitating experiment homogenization, convenient interexperimental comparisons, and translation of experimental results to clinical application.

show abstract

Impacts of Systemic Hypertension and Left Ventricular Hypertrophy on Outcome of Cardiopulmonary Resuscitation and Therapeutic Hypothermia in a Cardiac Arrest Model of Rat

Abstract: In this rat model, systemic hypertension and LVH did not affect ROSC. However, survival was dismal due to elevated severity of cardiac and cerebral injury in hypertensive animals regardless of short-duration hypothermia.

Cited by 7 publications

References 31 publications

Meta-analysis of targeted temperature management in animal models of cardiac arrest

Meta-analysis of targeted temperature management in animal models of cardiac arrest

Dietary EPA Increases Rat Mortality in Diabetes Mellitus, a Phenomenon Which Is Compensated by Green Tea Extract

Rat model of asphyxia-induced cardiac arrest and resuscitation

Contact Info

Product

Resources

About