The micropore structure of tight sandstone affects the efficiency of CO 2 displacement of crude oil. As the pressure changes, the oil displacement efficiency (E d ) in segments with different pore radii changes, and the asphaltene precipitation in the pores causes alterations in the pore structure and wettability, which constrain E d . Ten samples of tight sandstone from the Yanchang Formation in the Ordos Basin were selected for this study. A variety of methods, including X-ray diffraction (XRD), casting thin sections (CTS), scanning electron microscopy (SEM), high-pressure mercury intrusion (HPMI), CT scanning, and nuclear magnetic resonance (NMR) combined with CO 2 displacement, were used to study the efficiency of crude oil utilization and the amount of asphaltene deposited at different pore-throat radii, and then the impacts of pressure, pore structure, and wettability changes on E d were discussed. The findings indicate that samples have three types: macropore-fine throats (MF), medium pore-tiny throats (MT), and small poremicrothroats (SM). The MT exhibits a favorable configuration. The pore-throat radius of each sample can be divided into two segments, namely, large pore segments (P L ) and small pore segments (P S ), and the P L has a significant E d . The E d of the MF-type P S is constrained by pressure. The E d of P L is significantly affected by the pressure sensitivity for the MT, while the E d of P L for the SM structure is more affected by pressure. Changes in wettability and the precipitation of asphaltene are the results of the reaction between crude oil and CO 2 . In the MF, asphaltene precipitates from the P L , while in the MT and SM, asphaltene precipitates both from the P L and P S . The amount of asphaltene precipitation strongly affects the E d in P S . The oil wettability increases more obviously with better pore-throat configurations. This study offers a reference and foundational understanding for evaluating CO 2 displacement in tight sandstone reservoirs.