Impacts of the prostate stem cell antigen (PSCA) and<i>Clostridium perfringens</i>enterotoxin (CPE) on the apoptosis and cell cycle regulatory genes in PC3

Abedi, Saied; Doosti, Abbas; Jami, Mohammad‐Saeid

doi:10.1080/10826068.2019.1660892

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…The expression of transgenes introduced into cancer cells, referred to as suicide gene therapy, may be the first step towards developing a vaccine against prostate cancer. The authors [198] reported a 62.6% death rate of PC3 prostate cancer cells. Genes encoding apoptosis were overexpressed, whereas genes encoding cell cycling were repressed.…”

Section: Clostridium Perfringens Enterotoxinmentioning

confidence: 98%

“…The size of cancerous tumours treated with CPE was reduced by 59%, suggesting that CLDN 4-targetted CPE treatment may be used to treat prostate cancer. Abedi et al [198] constructed a recombinant plasmid containing the CPE and prostate stem cell antigen (PSCA) and named it pBudCE4.1-CPE-PSCA. The expression of transgenes introduced into cancer cells, referred to as suicide gene therapy, may be the first step towards developing a vaccine against prostate cancer.…”

Section: Clostridium Perfringens Enterotoxinmentioning

confidence: 99%

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Do Bacteria Provide an Alternative to Cancer Treatment and What Role Does Lactic Acid Bacteria Play?

Dicks

Vermeulen

2022

Microorganisms

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Cancer is one of the leading causes of mortality and morbidity worldwide. According to 2022 statistics from the World Health Organization (WHO), close to 10 million deaths have been reported in 2020 and it is estimated that the number of cancer cases world-wide could increase to 21.6 million by 2030. Breast, lung, thyroid, pancreatic, liver, prostate, bladder, kidney, pelvis, colon, and rectum cancers are the most prevalent. Each year, approximately 400,000 children develop cancer. Treatment between countries vary, but usually includes either surgery, radiotherapy, or chemotherapy. Modern treatments such as hormone-, immuno- and antibody-based therapies are becoming increasingly popular. Several recent reports have been published on toxins, antibiotics, bacteriocins, non-ribosomal peptides, polyketides, phenylpropanoids, phenylflavonoids, purine nucleosides, short chain fatty acids (SCFAs) and enzymes with anticancer properties. Most of these molecules target cancer cells in a selective manner, either directly or indirectly through specific pathways. This review discusses the role of bacteria, including lactic acid bacteria, and their metabolites in the treatment of cancer.

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Section: Clostridium Perfringens Enterotoxinmentioning

confidence: 98%

Section: Clostridium Perfringens Enterotoxinmentioning

confidence: 99%

Do Bacteria Provide an Alternative to Cancer Treatment and What Role Does Lactic Acid Bacteria Play?

Dicks

Vermeulen

2022

Microorganisms

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“…Toxic necrosis factor (CNF1) can accelerate the progression of prostate cancer by activating the Cdc42-PAK1 signal axis (69). Additionally, in some in vivo and in vitro studies, it has been found that some bacterial toxins show anti-tumor properties, such as alpha toxins (93) and enterotoxins (94)(95)(96). In these studies, it is shown that bacterial toxins can regulate the apoptosis of tumor cells through a variety of mechanisms.…”

Section: Direct Pathway Of Prostatic Microbiota Typical Bacteriamentioning

confidence: 99%

Prostate Microbiota and Prostate Cancer: A New Trend in Treatment

Che

Zhang

et al. 2021

Front. Oncol.

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Although the incidence and mortality of prostate cancer have gradually begun to decline in the past few years, it is still one of the leading causes of death from malignant tumors in the world. The occurrence and development of prostate cancer are affected by race, family history, microenvironment, and other factors. In recent decades, more and more studies have confirmed that prostate microflora in the tumor microenvironment may play an important role in the occurrence, development, and prognosis of prostate cancer. Microorganisms or their metabolites may affect the occurrence and metastasis of cancer cells or regulate anti-cancer immune surveillance. In addition, the use of tumor microenvironment bacteria in interventional targeting therapy of tumors also shows a unique advantage. In this review, we introduce the pathway of microbiota into prostate cancer, focusing on the mechanism of microorganisms in tumorigenesis and development, as well as the prospect and significance of microorganisms as tumor biomarkers and tumor prevention and treatment.

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Bacterial Peptides and Bacteriocins as Novel Treatment for Prostate Cancer

Zhang

et al. 2023

Int J Pept Res Ther

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Impacts of the prostate stem cell antigen (PSCA) andClostridium perfringensenterotoxin (CPE) on the apoptosis and cell cycle regulatory genes in PC3

Cited by 5 publications

References 35 publications

Do Bacteria Provide an Alternative to Cancer Treatment and What Role Does Lactic Acid Bacteria Play?

Do Bacteria Provide an Alternative to Cancer Treatment and What Role Does Lactic Acid Bacteria Play?

Prostate Microbiota and Prostate Cancer: A New Trend in Treatment

Bacterial Peptides and Bacteriocins as Novel Treatment for Prostate Cancer

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