Impacts of ‘two-level’ variability on the differential power for Montreal Cognitive Assessment (MoCA) in prodromal dementia

Lu, Hanna; Lam, Linda Chiu Wa

doi:10.1136/jnnp-2016-314435

Cited by 1 publication

(1 citation statement)

References 4 publications

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“…Similar to dispersion, studies have yielded inconclusive findings on group differences and diagnostic accuracy of inconsistency between control groups and aMCI groups (Chow et al, 2021;Christensen et al, 2005;Costa et al, 2019;Kay et al, 2017;Lu & Lam, 2017;McLaughlin et al, 2010;Ramratan et al, 2012;Strauss et al, 2007;Troyer et al, 2016;c.f., Gorus et al, 2008;Kay, 2017;Phillips et al, 2013;Tales et al, 2013;Tarnanas et al, 2015). As with dispersion, greater inconsistency is associated with greater odds of progression from normal aging to MCI, and from MCI to Alzheimer's dementia (Bielak et al, 2010;Haynes et al, 2017;Kochan et al, 2016;Ramratan, 2016;Tales et al, 2012), and a meta-analysis also supported a small positive association across studies between elevated inconsistency in mixed MCI types compared to controls (Aita, 2020).…”

Section: Inconsistency (Intraindividual Variability Across Trials)mentioning

confidence: 99%

Interindividual and intraindividual variability in amnestic mild cognitive impairment (aMCI) measured with an online cognitive assessment

LaPlume

Paterson

Gardner

et al. 2021

Journal of Clinical and Experimental Neuropsychology

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Introduction: Mean cognitive performance is worse in amnestic mild cognitive impairment (aMCI) compared to control groups. However, studies on variability of cognitive performance in aMCI have yielded inconclusive results, with many differences in variability measures and samples from one study to another.Methods: We examined variability in aMCI using an existing older adult sample (n=91; 51 with aMCI, 40 with normal cognition for age), measured with an online self-administered computerized cognitive assessment (Cogniciti's Brain Health Assessment). Our methodology extended past findings by using pure measures of variability (controlling for confounding effects of group performance or practice), and a clinically representative aMCI sample (reflecting the continuum of cognitive performance between normal cognition and aMCI).Results: Between-group t-tests showed significantly greater between-person variability (interindividual variability or diversity) in overall cognitive performance in aMCI than controls, with a small to moderate effect size, d = 0.44. No significant group differences were found in within-person variability (intraindividual variability) across cognitive tasks (dispersion) or across trials of a response time task (inconsistency), which may be because we used a sample measuring the continuum of cognitive performance. Exploratory correlation analyses showed that a worse overall score was associated with greater inter-and intraindividual variability, and that variability measures were correlated with each other, indicating people with worse cognitive performance were more variable.Discussion: The current study demonstrates that self-administered online tests can be used to remotely assess different types of variability in people at risk of Alzheimer`s. Our findings show small but significantly more interindividual differences in people with aMCI. This diversity is considered as 'noise' in standard assessments of mean performance, but offers an interesting and cognitively informative 'signal' in itself.

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Section: Inconsistency (Intraindividual Variability Across Trials)mentioning

confidence: 99%

Interindividual and intraindividual variability in amnestic mild cognitive impairment (aMCI) measured with an online cognitive assessment

LaPlume

Paterson

Gardner

et al. 2021

Journal of Clinical and Experimental Neuropsychology

View full text Add to dashboard Cite

show abstract

Impacts of ‘two-level’ variability on the differential power for Montreal Cognitive Assessment (MoCA) in prodromal dementia

Cited by 1 publication

References 4 publications

Interindividual and intraindividual variability in amnestic mild cognitive impairment (aMCI) measured with an online cognitive assessment

Interindividual and intraindividual variability in amnestic mild cognitive impairment (aMCI) measured with an online cognitive assessment

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