Impaired ACE2 glycosylation and protease activity in Fabry disease protects from COVID‐19

Caputo, Ilaria; Bertoldi, Giovanni; Driussi, Giulia; Sgarabotto, Luca; Carraro, Gianni; Stefanelli, Lucia Federica; Davis, Paul A.; Calò, Lorenzo A.

doi:10.1111/joim.13672

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…This was confirmed in our cohort of FD patients: only 1 out of 40 enzymatic-replacement-therapy-treated FD patients tested positive for COVID-19 with minor symptoms. In addition, we showed in these patients higher non-glycosylated ACE2 levels, lower Cat-L activity, and a lower glycosilated/non glycosylated ACE2 ratio compared to healthy subjects [20], giving a molecular rationale for this "protection".…”

Section: Fabry Disease and Sars-cov-2mentioning

confidence: 69%

“Every Cloud Has a Silver Lining”: How Three Rare Diseases Defend Themselves from COVID-19 and What We Have Learnt from It

Cacciapuoti,

Caputo,

Stefanelli

et al. 2024

Clinics and Practice

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The process of SARS-CoV-2 infection, responsible for the COVID-19 pandemic, is carried out through different steps, with the interaction between ACE2 and Spike protein (S) being crucial. Besides of that, the acidic environment of endosomes seems to play a relevant role in the virus uptake into cells and its intracellular replication. Patients affected by two rare genetic tubulopathies, Gitelman’s and Bartter’s Syndromes, and a rare genetic metabolic disease, Fabry Disease, have shown intrinsic protection from SARS-CoV-2 infection and COVID-19 on account of specific intrinsic features that interfere with the virus uptake into cells and its intracellular replication, which will be reported and discussed in this paper, providing interesting insights for present and future research.

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Section: Fabry Disease and Sars-cov-2mentioning

confidence: 69%

“Every Cloud Has a Silver Lining”: How Three Rare Diseases Defend Themselves from COVID-19 and What We Have Learnt from It

Cacciapuoti,

Caputo,

Stefanelli

et al. 2024

Clinics and Practice

Self Cite

View full text Add to dashboard Cite

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ACE2: the node connecting the lung cancer and COVID-19

Liao

2024

Am J Cancer Res

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Angiotensin-converting Enzyme 2 (ACE2) collaborates with Angiotensin (Ang) 1-7 and Mas receptors to establish the ACE2-Ang (1-7)-Mas receptor axis. ACE2 impacts lung function and can cause lung injury due to its inflammatory effects. Additionally, ACE2 contributes to pulmonary vasculature dysfunction, resulting in pulmonary hypertension. In addition, ACE2 is a receptor for coronavirus entry into host cells, leading to coronavirus infection. Lung cancer, one of the most common respiratory diseases worldwide, has a high rate of infection. Elevated levels of ACE2 in lung cancer patients, which increase the risk of SARS-CoV-2 infection and severe disease, have been demonstrated in clinical studies and by molecular mechanisms. The association between lung cancer and SARS-CoV-2 is closely linked to ACE2. This review examines the basic pathophysiological role of ACE2 in the lung, the longterm effects of SARS-CoV-2 infection on lung function, the development of pulmonary fibrosis, chronic inflammation in long-term COVID patients, and the clinical research and mechanisms underlying the increased susceptibility of lung cancer patients to the virus. Possible mechanisms of lung cancer in SARS-CoV-2-infected individuals and the potential role of ACE2 in this process are also explored in this review. The role of ACE2 as a therapeutic target in the novel coronavirus infection process is also summarized. This will help to inform prevention and treatment of longterm pulmonary complications in patients.

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Impaired ACE2 glycosylation and protease activity in Fabry disease protects from COVID‐19

Cited by 2 publications

References 10 publications

“Every Cloud Has a Silver Lining”: How Three Rare Diseases Defend Themselves from COVID-19 and What We Have Learnt from It

“Every Cloud Has a Silver Lining”: How Three Rare Diseases Defend Themselves from COVID-19 and What We Have Learnt from It

ACE2: the node connecting the lung cancer and COVID-19

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