Impaired Antioxidant Defence Status Is Associated With Metabolic-Inflammatory Risk Factors in Preterm Children With Extrauterine Growth Restriction: The BIORICA Cohort Study

Ordóñez-Díaz, María Dolores; Gil-Campos, Mercedes; Flores-Rojas, Katherine; Muñoz-Villanueva, María Carmen; Mesa, María Dolores; Torre-Aguilar, María José de la; Gil, Ángel; Pérez-Navero, Juan Luís

doi:10.3389/fnut.2021.793862

Cited by 5 publications

(7 citation statements)

References 60 publications

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“…Maintaining a 10-year follow-up is difficult and especially within a group of preterm patients without EUGR and other comorbidities. Given that EUGR and reference groups exhibited the greatest differences during prepuberty stage [ 27 , 28 , 29 ], comparisons between these extreme groups were more appropriate, not considering a third and small group of preterm without EUGR.…”

Section: Discussionmentioning

confidence: 99%

“…Perinatal clinical data and personal and family health records were collected from the clinical history of both groups, as published previously [21,22]. The median GA for EUGR participants at birth was 29.5 weeks (interquartile range (IQR) [25][26][27][28][29][30][31][32]. An extended physical exploration was conducted for all participants by the research physician.…”

Section: Clinical History Physical Examination and Blood Pressure Mea...mentioning

confidence: 99%

“…Recent studies, some of which were conducted by our research group, have shown that prepubertal children with a history of EUGR present a greater risk of metabolic diseases than their preterm and term counterparts with no EUGR, showing higher blood pressure (BP) levels, proinflammatory biomarkers and deficiency in the antioxidant enzyme system [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. In this way, the direct consequences of prematurity are differentiated from the consequences of the EUGR condition.…”

Section: Introductionmentioning

confidence: 99%

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Metabolic and Low-Grade Inflammation Risk in Young Adults with a History of Extrauterine Growth Restriction

Palomino-Fernández,

Pastor-Villaescusa,

Velasco

et al. 2024

Nutrients

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Children with a history of extrauterine growth restriction (EUGR), later at prepubertal age, exhibit an increased metabolic risk including risen insulin resistance and low-grade inflammation. However, the progression of such metabolic changes after puberty and the lasting health implications have not yet been investigated. The objective of this study was to ascertain whether young adults with a history of EUGR faced increased vulnerability to metabolic disorders. A study was conducted comparing a group of adults with a history of EUGR with a healthy reference group. A total of 110 young adults (36 from the EUGR group and 74 from the control group) were included. Anthropometric variables, blood pressure (BP), general biochemical parameters, plasma inflammatory biomarkers, and adipokines were assessed. Compared to the reference group, the EUGR group had a shorter height and body weight with higher lean mass and waist circumference, as well as a greater percentage of individuals with high BP. In addition, EUGR patients had higher values of insulin, HOMA-IR, nerve growth factor, and leptin, and lower levels of adiponectin and resistin. The present study suggests that young adults with a history of EUGR present increased metabolic risk factors therefore, clinical follow-up should be considered.

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Section: Discussionmentioning

confidence: 99%

Section: Clinical History Physical Examination and Blood Pressure Mea...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metabolic and Low-Grade Inflammation Risk in Young Adults with a History of Extrauterine Growth Restriction

Palomino-Fernández,

Pastor-Villaescusa,

Velasco

et al. 2024

Nutrients

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“…Additionally, fetal membrane CAT activity correlated with head circumference and birth weight. Ordóñez-Díaz et al [100] associated extra uterine growth restriction with an impaired antioxidant defense status. Similarly, Karowicz-Bilinska et al [101] and Luo et al [102] demonstrated that IUGR is associated with greater placental ROS and oxidative injury.…”

Section: Oxidative Stress and Fe Cu And Zn Concentrationsmentioning

confidence: 99%

The Trace Element Concentrations and Oxidative Stress Parameters in Afterbirths from Women with Multiple Pregnancies

et al. 2023

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The aim of this study was to evaluate the intensity of oxidative stress by measuring the concentrations of lipid peroxidation products (LPO) in fetal membrane, umbilical cord, and placenta samples obtained from women with multiple pregnancies. Additionally, the effectiveness of protection against oxidative stress was assessed by measuring the activity of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and glutathione reductase (GR). Due to the role of iron (Fe), copper (Cu), and zinc (Zn) as cofactors for antioxidant enzymes, the concentrations of these elements were also analyzed in the studied afterbirths. The obtained data were compared with newborn parameters, selected environmental factors, and the health status of women during pregnancy to determine the relationship between oxidative stress and the health of women and their offspring during pregnancy. The study involved women (n = 22) with multiple pregnancies and their newborns (n = 45). The Fe, Zn, and Cu levels in the placenta, umbilical cord, and fetal membrane were determined using inductively coupled plasma atomic emission spectroscopy (ICP-OES) using an ICAP 7400 Duo system. Commercial assays were used to determine SOD, GPx, GR, CAT, and LPO activity levels. The determinations were made spectrophotometrically. The present study also investigated the relationships between trace element concentrations in fetal membrane, placenta, and umbilical cord samples and various maternal and infant parameters in women. Notably, a strong positive correlation was observed between Cu and Zn concentrations in the fetal membrane (p = 0.66) and between Zn and Fe concentrations in the placenta (p = 0.61). The fetal membrane Zn concentration exhibited a negative correlation with shoulder width (p = −0.35), while the placenta Cu concentration was positively correlated with placenta weight (p = 0.46) and shoulder width (p = 0.36). The umbilical cord Cu level was positively correlated with head circumference (p = 0.36) and birth weight (p = 0.35), while the placenta Fe concentration was positively correlated with placenta weight (p = 0.33). Furthermore, correlations were determined between the parameters of antioxidative stress (GPx, GR, CAT, SOD) and oxidative stress (LPO) and the parameters of infants and maternal characteristics. A negative correlation was observed between Fe and LPO product concentrations in the fetal membrane (p = −0.50) and placenta (p = −0.58), while the Cu concentration positively correlated with SOD activity in the umbilical cord (p = 0.55). Given that multiple pregnancies are associated with various complications, such as preterm birth, gestational hypertension, gestational diabetes, and placental and umbilical cord abnormalities, research in this area is crucial for preventing obstetric failures. Our results could serve as comparative data for future studies. However, we advise caution when interpreting our results, despite achieving statistical significance.

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“…Determination of plasma antioxidants (retinol, β-carotene, and α-tocopherol). Plasma concentrations of retinol, β-carotene, and α-tocopherol are determined by solvent extraction and ultrahigh-pressure liquid chromatography coupled to mass spectrometry (UHPLC-MS) as reported elsewhere [158,159].…”

Section: Evaluation Of the Antioxidant Defense Systemmentioning

confidence: 99%

Effect of Regular Consumption of a Miraculin-Based Food Supplement on Taste Perception and Nutritional Status in Malnourished Cancer Patients: A Triple-Blind, Randomized, Placebo-Controlled Clinical Trial-CLINMIR Pilot Protocol

López-Plaza,

Gil,

Menéndez-Rey

et al. 2023

Nutrients

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Taste disorders are common among cancer patients undergoing chemotherapy, with a prevalence ranging from 20% to 86%, persisting throughout treatment. This condition leads to reduced food consumption, increasing the risk of malnutrition. Malnutrition is associated not only with worse treatment efficacy and poor disease prognosis but also with reduced functional status and quality of life. The fruit of Synsepalum dulcificum (Daniell), commonly known as miracle berry or miracle fruit, contains miraculin, a taste-modifying protein with profound effects on taste perception. The CLINMIR Protocol is a triple-blind, randomized, placebo-controlled clinical trial designed to evaluate the regular consumption of a food supplement containing a miraculin-based novel food, dried miracle berry (DMB), on the taste perception (measured through electrogustometry) and nutritional status (evaluated through the GLIM Criteria) of malnourished cancer patients under active antineoplastic treatment. To this end, a pilot study was designed with 30 randomized patients divided into three study arms (150 mg DMB + 150 mg freeze-dried strawberries, 300 mg DMB, or placebo) for three months. Throughout the five main visits, an exhaustive assessment of different parameters susceptible to improvement through regular consumption of the miraculin-based food supplement will be conducted, including electrical and chemical taste perception, smell perception, nutritional and morphofunctional assessment, diet, quality of life, the fatty acid profile of erythrocytes, levels of inflammatory and cancer-associated cytokines, oxidative stress, antioxidant defense system, plasma metabolomics, and saliva and stool microbiota. The primary anticipated result is that malnourished cancer patients with taste distortion who consume the miraculin-based food supplement will report an improvement in food taste perception. This improvement translates into increased food intake, thereby ameliorating their nutritional status and mitigating associated risks. Additionally, the study aims to pinpoint the optimal dosage that provides maximal benefits. The protocol adheres to the SPIRIT 2013 Statement, which provides evidence-based recommendations and is widely endorsed as an international standard for trial protocols. The clinical trial protocol has been registered at the platform for Clinical Trials (NCT05486260).

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Impaired Antioxidant Defence Status Is Associated With Metabolic-Inflammatory Risk Factors in Preterm Children With Extrauterine Growth Restriction: The BIORICA Cohort Study

Cited by 5 publications

References 60 publications

Metabolic and Low-Grade Inflammation Risk in Young Adults with a History of Extrauterine Growth Restriction

Metabolic and Low-Grade Inflammation Risk in Young Adults with a History of Extrauterine Growth Restriction

The Trace Element Concentrations and Oxidative Stress Parameters in Afterbirths from Women with Multiple Pregnancies

Effect of Regular Consumption of a Miraculin-Based Food Supplement on Taste Perception and Nutritional Status in Malnourished Cancer Patients: A Triple-Blind, Randomized, Placebo-Controlled Clinical Trial-CLINMIR Pilot Protocol

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