Impaired ascorbic acid metabolism in streptozotocin-induced diabetic rats

Kashiba, Misato; Oka, Jun; Ichikawa, Rumi; Kasahara, Emiko; Inayama, Takayo; Kageyama, Asako; Kageyama, Haruaki; Osaka, Toshimasa; Umegaki, Keizo; Matsumoto, Akiyo; Ishikawa, Takahiro; Nishikimi, Morimitsu; Inoue, Masayasu; Inoue, Shuji

doi:10.1016/s0891-5849(02)01010-9

Cited by 40 publications

(29 citation statements)

References 31 publications

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“…In the present study, the effects of the PL and TG types of dietary DHA on the lipid peroxide of brain and serum in the STZ-induced diabetic mice were compared. It is known that the lipid peroxidative levels increase in the STZ-induced diabetic rats (20)(21)(22)29). Thus, the mice in this experiment were evaluated under oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…In diabetic patients, the serum lipid peroxide level was reported to have increased ( 19 ). There are several reports of the effects of the streptozotocin treatment on the lipid peroxidation in rats, such as decreasing the ascorbic acid levels in the plasma, liver and kidney ( 20 ), increasing the lipid peroxide levels of the retina and kidney ( 21 ), and increasing the activity of mitochondrial oxidative markers of the liver and kidney ( 22 ).…”

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confidence: 99%

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Effect of Dietary Docosahexaenoic Acid Connecting Phospholipids on the Lipid Peroxidation of the Brain in Mice

Hiratsuka

Ishihara

Kitagawa³

et al. 2008

J Nutr Sci Vitaminol

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SummaryThe effect of dietary docosahexaenoic acid (DHA, C22:6 n -3) with two lipid types on lipid peroxidation of the brain was investigated in streptozotocin (STZ)-induced diabetic mice. Each group of female Balb/c mice was fed a diet containing DHA-connecting phospholipids (DHA-PL) or DHA-connecting triacylglycerols (DHA-TG) for 5 wk. Safflower oil was fed as the control. The lipid peroxide level of the brain was significantly lower in the mice fed the DHA-PL diet when compared to those fed the DHA-TG and safflower oil diets, while the ␣ -tocopherol level was significantly higher in the mice fed the DHA-PL diet than in those fed the DHA-TG and safflower oil diets. The DHA level of phosphatidylethanolamine in the brain was significantly higher in the mice fed the DHA-PL diet than in those fed the safflower oil diet. The dimethylacetal levels were significantly higher in the mice fed the DHA-PL diet than in those fed the safflower oil and DHA-TG diets. These results suggest that the dietary DHA-connecting phospholipids have an antioxidant activity on the brain lipids in mice, and the effect may be related to the brain plasmalogen.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Effect of Dietary Docosahexaenoic Acid Connecting Phospholipids on the Lipid Peroxidation of the Brain in Mice

Hiratsuka

Ishihara

Kitagawa³

et al. 2008

J Nutr Sci Vitaminol

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“…Table 1 shows that the control diabetic group had typical characteristics of type 1 diabetes such as a decrease in the body weight and hyperglycemia compared with the non-diabetic rats, which were similar to previous reports. 5,17) Daily supplementation of AA for 2 weeks did not show a significant effect on either body weight loss or hyperglycemia in the diabetic rats.…”

Section: Physiological Characteristic Parametermentioning

confidence: 93%

“…15) There is evidence of lower levels of the concentrations of AA in the plasma, liver and kidney of diabetic animals and humans. 16,17) The decrease in AA of most tissues may be due to its enhanced consumption by elevated oxidative stress in the diabetic state. Indeed, AA supplementation prevents the development of diabetic complications associated with a decrease in the levels of hyperglycemia, hyperlipidemia, hyperketonemia, 18) and lipid peroxidation in the liver and muscle 19) of diabetic animals.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Oral Administrated Ascorbic Acid against Oxidative Stress and Neuronal Damage after Cerebral Ischemia/Reperfusion in Diabetic Rats

Iwata

Okazaki

Kamiuchi

et al. 2010

JOURNAL OF HEALTH SCIENCE

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Diabetes enhances oxidative stress and exacerbates acute ischemic injury. Previous studies have demonstrated that infarct volumes were greater in diabetic animals caused by a transient cerebral ischemia as compared with nondiabetic animals. Ascorbic acid (AA) as a naturally occurring major antioxidant is reported to be low in diabetic tissues. Therefore, we examined the effects of daily supplementation of AA on lipid peroxidation and the activity of antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) in streptozotocin (STZ)-induced diabetic rat brain. Additionally, we also investigated whether AA improves the exacerbation of neuronal damage induced by middle cerebral artery occlusion followed by reperfusion (MCAO/Re) in diabetic state. Type1-diabetes was induced in male Sprague Dawley rats by STZ (60 mg/kg of intraperitoneal injection). Five weeks after STZinjection, the diabetic rats showed enhanced lipid peroxidation and impaired activity of antioxidant enzymes in the brain. Furthermore, the gene expression of glucose transporter GLUT1, which locates in the endothelial cells of the blood-brain-barrier and transports oxidized AA as the main source of AA supply to the brain, was downregulated in the diabetic brain. AA-supplemented (100 mg/kg daily, 2 weeks) diabetic rats showed normal levels of all these parameters. A diabetic state markedly aggravated MCAO/Re-induced neurological deficits and cerebral injury assessed by infarction volume. Treatment of AA remarkably improved both parameters in the diabetic rats. These results suggest that daily intake of AA relieves the exacerbation of cerebral ischemic injury in a diabetic state, which may be attributed to improvement of augmented oxidative stress.

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“…[9] The level of Vitamin C and E in plasma and renal tissues is significantly reduced in diabetic patients. [10][11][12] Decrease in Vitamin C causes hyperlipidemia and hypertension. [13,14] Some studies showed that Vitamins C and E are important to prevent or alleviate the complications of diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Effect of Diabetes on the Rat Renal Cortex and the Possible Protective Role of Vitamins C and E

Ali¹,

Hulail²,

Hegazy³

et al. 2017

AIMDR

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Impaired ascorbic acid metabolism in streptozotocin-induced diabetic rats

Cited by 40 publications

References 31 publications

Effect of Dietary Docosahexaenoic Acid Connecting Phospholipids on the Lipid Peroxidation of the Brain in Mice

Effect of Dietary Docosahexaenoic Acid Connecting Phospholipids on the Lipid Peroxidation of the Brain in Mice

Protective Effects of Oral Administrated Ascorbic Acid against Oxidative Stress and Neuronal Damage after Cerebral Ischemia/Reperfusion in Diabetic Rats

Effect of Diabetes on the Rat Renal Cortex and the Possible Protective Role of Vitamins C and E

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