Impaired Auditory Brainstem-evoked Responses in Insulin-dependent Diabetic Subjects

Abstract

Auditory brainstem-evoked responses (ABR) were recorded from the scalp of 30 normoacoustic insulin-dependent diabetic subjects, aged between 15 and 41 yr (29 +/- 7 yr). Three different stimulus repetition rates (11, 37, and 87 cps) were used. The results were compared with those obtained from 20 age- and sex-matched, normoacoustic control subjects. In diabetic patients, metabolic control (mean daily plasma glucose, glycosylated hemoglobin) and the presence of retinopathy, nephropathy, and somatic neuropathy were also investigated. The latencies (ms) of ABR waves were significantly impaired in diabetic subjects as compared with normals. Peripheral transmission time (wave I) and central transmission time (waves I-V) were also significantly delayed in diabetic subjects. Moreover, by increasing stimulus repetition rates, a significant increase in waves I-V shift was observed in diabetic patients. ABR impairment was not related to glucose balance, to the duration of diabetes, or to the presence of the diabetic retinopathy, nephropathy, and somatic neuropathy. In conclusion, diabetic neuropathy is characterized not only by somatic and autonomic nerve dysfunctions, but also by the early involvement of the central nervous system (CNS). ABR recording can represent a useful, noninvasive, simple procedure to detect both acoustic nerve and CNS damage.

Evaluation of auditory brain-stem evoked response in middle: Aged type 2 diabetes mellitus with normal hearing subjects

“…A substantial delay of interpeak latency III-V shows that the diabetic neuropathy is at upper brain-stem level. These findings are similar to Durmus et al [15,18] It seems that ABR test should be a complementary diagnostic tool for early diagnosis of any auditory alterations and periodic evaluation in of diabetes for early intervention regarding metabolic regulations. of peripheral transmission time (wave I) in the auditory nerve that occurred secondary to diabetic neuropathy.…”

“…[17] The delay in inter peak latencies I-III and I-V are evidence of central conduction delay in the auditory pathway of diabetics at the level of brain-stem and mid-brain. This delay in latency for wave III and V in diabetics indicates neuropathy at brain-stem and mid-brain level in the auditory pathway Fedele et al [18] In the present study, hearing was evaluated in type 2 DM patients. Similar studies have been conducted on type 1 DM.…”

Type-2 diabetes mellitus and auditory brainstem response

“…Fedele et al . [8] recorded BERA from scalp of 30 normoacoustic insulin-dependent diabetes subjects and found peripheral transmission time (wave I) and central transmission time (wave I-V) to be delayed. Goldsher et al .…”

Cranial Nerve Dysfunction in Conscious Galactosemic Rats as Measured by the Auditory-Evoked Brainstem Response

“…Some of these studies found changes in the early conponents of the ABR (21,22,24,26), while others described deficits in more central components (25,27). These functional reports support studies which have shown cranial nerve demyelination (29)(30)(31) and hearing deficits (31,32) in diabetic patients.…”

“…There are several clinical reports of deficits in the ABR of diabetics (21)(22)(23)(24)(25)(26)(27). Some of these studies found changes in the early conponents of the ABR (21,22,24,26), while others described deficits in more central components (25,27).…”