Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1)

Ara, Toshiaki; Nakamura, Y.; Egawa, Takeshi; Sugiyama, Tatsuki; Abe, Kuniya; Kishimoto, Tadamitsu; Matsui, Yasuhisa; Nagasawa, Takashi

doi:10.1073/pnas.0730719100

Cited by 292 publications

(212 citation statements)

References 33 publications

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“…To support this all TCSC express CXCR4 receptor on their surface and follow an SDF-1 gradient. 34,38,[50][51][52][53][54][55] Thus the SDF-1-CXCR4 axis alone or in combination with other chemoattractants plays a crucial role in accumulation of TCSC in developing BM. These cells find in BM a permissive environment to survive, and what we believe may play an underappreciated role as a reserve pool of stem cells for organ/tissue regeneration during postnatal life ( Figure 1).…”

Section: Developmental Migration Of Stem Cellsmentioning

confidence: 99%

Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells

et al. 2005

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Evidence is presented that bone marrow (BM) in addition to CD45 positive hematopoietic stem cells contains a rare population of heterogenous CD45 negative nonhematopoietic tissue committed stem cells (TCSC). These nonhematopoietic TCSC (i) are enriched in population of CXCR4 þ CD34 þ AC133 þ lin À CD45 À and CXCR4 þ Sca-1 þ lin À CD45 À in humans and mice, respectively, (ii) display several markers of pluripotent stem cells (PSC) and (iii) as we envision are deposited in BM early in development. Thus, since BM contains versatile nonhematopoietic stem cells, previous studies on plasticity trans-dedifferentiation of BM-derived hematopoietic stem cells (HSC) that did not include proper controls to exclude this possibility could lead to wrong interpretations. Therefore, in this spotlight review we present this alternative explanation of 'plasticity' of BMderived stem cells based on the assumption that BM stem cells are heterogenous. We also discuss a potential relationship of TCSC/PSC identified by us with other BM-derived CD45 negative nonhematopoietic stem cells that were recently identified by other investigators (eg MSC, MAPC, USSC and MIAMI cells). Finally, we discuss perspectives and pitfalls in potential application of these cells in regenerative medicine.

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Section: Developmental Migration Of Stem Cellsmentioning

confidence: 99%

Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells

et al. 2005

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“…These cells are also CXCR4 þ and respond robustly to an SDF-1 gradient. 21,22 It was proposed that pluripotent PGC could differentiate into HSC and could be a potential source of definitive HSC in embryos during gastrulation. 23 This interesting concept, however, requires further studies.…”

Section: The Role Of the Sdf-1-cxcr4 Axis In Normal Development And Hmentioning

confidence: 99%

“…We hypothesize that VSELs could be related to a population of PGC, which respond robustly to an SDF-1 gradient and which during early embryogenesis migrate through the embryo proper (e.g., splanchnopleura and AGM region) to genital ridges. [21][22][23] It is possible that in response to an SDF-1 gradient, some of these cells could also seed to other organs, such as fetal liver and subsequently BM. To support this hypothesis, both VSELs as PGC are CXCR4 þ Oct-4 þ SSEA-1 þ and are fetal alkaline phosphatase positive.…”

Section: Concept Of Circulation Of Cxcr4 þ Non-hematopoietic Nscmentioning

confidence: 99%

The pleiotropic effects of the SDF-1–CXCR4 axis in organogenesis, regeneration and tumorigenesis

et al. 2006

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Proper response of normal stem cells (NSC) to motomorphogens and chemoattractants plays a pivotal role in organ development and renewal/regeneration of damaged tissues. Similar chemoattractants may also regulate metastasis of cancer stem cells (CSC). Growing experimental evidence indicates that both NSC and CSC express G-protein-coupled seven-transmembrane span receptor CXCR4 and respond to its specific ligand a-chemokine stromal derived factor-1 (SDF-1), which is expressed by stroma cells from different tissues. In addition, a population of very small embryonic-like (VSEL) stem cells that express CXCR4 and respond robustly to an SDF-1 gradient was recently identified in adult tissues. VSELs express several markers of embryonic and primordial germ cells. It is proposed that these cells are deposited early in the development as a dormant pool of embryonic/pluripotent NSC. Expression of both CXCR4 and SDF-1 is upregulated in response to tissue hypoxia and damage signal attracting circulating NSC and CSC. Thus, pharmacological modulation of the SDF-1-CXCR4 axis may lead to the development of new therapeutic strategies to enhance mobilization of CXCR4 þ NSC and their homing to damaged organs as well as inhibition of the metastasis of CXCR4 þ cancer cells.

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“…The CXCR4-CXCL12 chemokine axis is required for normal development of the cardiovascular, hematopoietic, gonadal and nervous systems [1][2][3][4][5][6]. As such, the CXCR4 receptor is detected in various types of cells, including hematopoietic and vascular endothelial cells, while it is important to note that CXCR4 expression in endothelial cells of the developing embryo is restricted to arteries such as the dorsal aorta and mesenteric arteries [2,7].…”

Section: Introductionmentioning

confidence: 99%

Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration

Hayashi

Kume

2008

Biochemical and Biophysical Research Communications

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Foxc1 and Foxc2 transcription factors are required for vascular development. However, the molecular mechanisms by which Foxc1 and Foxc2 control angiogenesis, the growth of new blood vessels from pre-existing vessels and capillaries, remain unknown. CXC chemokine ligand 12 (CXCL12) and its receptor, CXCR4, are critical for the process of angiogenesis, including the migration and tube formation of endothelial cells. Here we show that Foxc1 and Foxc2 directly induce CXCR4 expression by activating its promoter in endothelial cells. Furthermore, Foxc1-deficient endothelial cells show a significant reduction in CXCR4 expression as well as CXCL12-stimulated migration. Taken together, these results provide novel evidence that Foxc transcription factors are important regulators of the chemotactic motility of endothelial cells through the induction of CXCR4 expression.

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Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1)

Cited by 292 publications

References 33 publications

Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells

Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells

The pleiotropic effects of the SDF-1–CXCR4 axis in organogenesis, regeneration and tumorigenesis

Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration

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