Impaired cutaneous T‐cell attracting chemokine elevation and adipose‐derived stromal cell migration in a high‐glucose environment cause poor diabetic wound healing

Wang, Wei‐Ting; Lee, Su-Shin; Wang, Ya-Chin; Lai, Ya-Wei; Kuo, Yur‐Ren; Chen, Yueh-Bih Tang; Liu, Yu-Sen; Wu, Yi-Chia

doi:10.1016/j.kjms.2018.05.002

Cited by 12 publications

(11 citation statements)

References 31 publications

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“…The involvement of lymphocytes takes place in a second stage beyond the first 72 h, having a role in modulating the healing processes through the synthesis of the extracellular matrix and the remodeling collagen. There are studies in which the inhibition of T lymphocytes has resulted in decreased healing tissue resistance and poor collagen synthesis [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil/Lymphocyte Ratio as Predictor of Anastomotic Leak after Gastric Cancer Surgery

et al. 2020

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Introduction. Neutrophil/lymphocyte ratio (NLR) is known as a prognostic for the outcome of the patients with gastric cancer. As no definite risk marker for anastomotic leakage after gastric resection was identified, we investigated the possible role of NLR. Methods. Peripheral blood count for neutrophils and lymphocytes was done at the patient’s admission. We retrospectively evaluated 204 gastric cancer patients, who underwent gastric resection, comparing the values of NLR between the group of patients with anastomotic leakage and those without complications. Results. Using the ROC curve, we found the cutoff value of NLR, which permitted the comparison of the group with low NLR, presenting increased NLR. The cutoff value for NLR was 3.54. Between the two groups, we could observe statistically significant differences in developing fistula (p < 0.01) and complications leading to death (p < 0.025). The odds ratio for patients with NLR greater than 3.54 to develop anastomotic leak was 17.62, compared to those with lower NLR. Conclusion. Peripheral blood NLR proved to be a predictor for anastomotic leakage.

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Section: Discussionmentioning

confidence: 99%

Neutrophil/Lymphocyte Ratio as Predictor of Anastomotic Leak after Gastric Cancer Surgery

et al. 2020

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“…Amongst MSCs, highly abundant and easily obtainable adipose-derived stem cells (ASCs), have been well recognized to be another promising candidate applying in diabetic wound healing [ 107 ]. ASCs share a high similarity of phenotypic and functional characteristics with bone marrow-derived MSCs as ASCs not only present with the capacity to differentiate into diverse cell lineages, such as adipogenesis, chondrogenesis, osteogenesis, and myogenesis [ 108 ], but also promote cell growth and accelerate wound healing by secreting a multitude of growth factors including VEGF, FGF, and HGF [ 109 ].…”

Section: Stem Cell Therapy In Diabetic Wound Healingmentioning

confidence: 99%

“…We have discovered that local administration of ASCs into the wound margin triggered angiogenesis and increased tissue regeneration, which further promoted diabetic wound healing through paracrine and autocrine mechanisms including an increase in von Willebrand factor and VEGF in streptozotocin (STZ)-induced diabetic rodent model [ 110 ]. We have also reported that the exogenous replenishment of the cutaneous CTACK/CCL27 at least partially restored the migration ability of ASCs, which was diminished in a high-glucose condition, and might eventually improve diabetic wound healing [ 107 ]. These studies strongly suggest that delayed wound healing in patients suffering from diabetes may be attributed to suppressed expressions of growth factors and regulatory cytokines such as CTACK/CCL27, which further lead to a deficient stem cell migration to the wound sites, thus implicating that the exogenous administration of ASCs contribute to diabetic wound healing.…”

Section: Stem Cell Therapy In Diabetic Wound Healingmentioning

confidence: 99%

Stem Cell-Based Therapeutic Strategies in Diabetic Wound Healing

et al. 2022

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Impaired wound healing and especially the “all-too-common” occurrence of associated diabetic foot ulcers (DFU) are becoming an increasingly urgent and deteriorating healthcare issue, which drastically impact the quality of life and further heighten the risks of infection and amputation in patients with diabetes mellitus. Amongst the multifactorial wound healing determinants, glycemic dysregulation has been identified to be the primary casual factor of poor wound healing. Unfortunately, current therapeutic modalities merely serve as moderate symptomatic relieves but often fail to completely restore the wound site to its pre-injury state and prevent further recurrence. Stem cell-based therapeutics have been employed for its promising potential to address the root of the problem as they not only exhibit the capacity for self-renewal and differentiation towards multiple lineages, but also have been disclosed to participate in mediating variant growth factors and cytokines. Herein we review the current literatures on the therapeutic benefits of using various kinds of stem cells, including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), and adipose-derived stem cells (ASCs) in diabetic wound healing by searching on the PubMed® Database for publications. This study shall serve as an overview of the current body of research with particular focus on autologous ASCs and the laboratory expandable iPSCs in hope of shedding more light on this attractive therapy so as to elevate the efficacy of wound healing that is almost always compromised in diabetic patients.

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“…Экспрессия CCL27 нарушена в тканях при диабете. Отсутствие CCL27 снижает привлечение T-клеток к поврежденным тканям, что является одной из причин плохого заживления тканей при диабете [112].…”

Section: индикаторы воспалительного старенияunclassified

Prospects for assessing the biological and immunological age of a person by blood factors

Kurgan

Panova

Silakova

et al. 2021

Science and Innovations in Medicine

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According to the WHO, by 2050 in developed countries, the population over 60 years old will double. This will lead to a further increase in the retirement age and an elevation of burden on the health care system. Therefore, there is an acute issue of maintaining health and prolonging active longevity, as well as the introduction of monitoring for prevention of premature aging and age-related disorders to avoid early disability. The review aims to discuss the aging process and identify critical blood factors affecting or indicating progress in biological aging. The connection of biological age, the regenerative and immune systems aging with the shift in circulating blood factors have been evaluated. The concepts of "health and longevity hygiene" and the concept of "immunological age" are debated. Perspective methods of rapid and multiplex analyzes of blood factors are discussed, as well as the prospects for preliminary analysis of biological and immunological age at home with subsequent processing in high-tech centers to identify risk groups and monitor healthy aging. Approaches to protecting health, slowing aging and rejuvenating the elderly, maintaining healthy aging, and prolonging active life have been defined.

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Impaired cutaneous T‐cell attracting chemokine elevation and adipose‐derived stromal cell migration in a high‐glucose environment cause poor diabetic wound healing

Cited by 12 publications

References 31 publications

Neutrophil/Lymphocyte Ratio as Predictor of Anastomotic Leak after Gastric Cancer Surgery

Neutrophil/Lymphocyte Ratio as Predictor of Anastomotic Leak after Gastric Cancer Surgery

Stem Cell-Based Therapeutic Strategies in Diabetic Wound Healing

Prospects for assessing the biological and immunological age of a person by blood factors

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