Impaired cytokine production by bone marrow stromal cells of immunodeficient mice

Hamburger, Anne W.

doi:10.1111/j.1365-2141.1995.tb05192.x

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…In vivo and in vitro studies have suggested both a direct effect on stem progenitor cells and an indirect effect via cells of the bone marrow environment. 23,35,36 Further studies are required to elucidate the mechanism whereby clinically asymptomatic HIV infection might cause depressed erythropoiesis.…”

Section: Discussionmentioning

confidence: 99%

The relationship between asymptomatic human immunodeficiency virus infection and the prevalence and severity of anemia in pregnant Malawian women.

Broek¹,

White²,

Neilson³

1998

The American Journal of Tropical Medicine and Hygiene

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Abstract. The relationship between asymptomatic human immunodeficiency virus (HIV) infection and blood hemoglobin (Hb) concentration was examined in anemic pregnant women from a population with high prevalence of both anemia (60%) and HIV seropositivity (30%). Sera from 155 pregnant women with Hb levels Ͻ 10.5 g/dL were tested for HIV status, C-reactive protein (CRP), vitamin B 12 , retinol, and folate levels. The observed prevalence of HIV seropositivity in the group of women with anemia was 47.1% (95% confidence interval ϭ 39.2-55.0%). This is significantly higher than the HIV prevalence in the whole population (30.1%; P Ͻ 0.001). Median Hb values in HIV-seropositive and -seronegative women with anemia were 8.40 g/dL and 8.95 g/dL, respectively. Serum retinol, vitamin B 12 , and folate levels were not significantly different in the HIV-seropositive and -seronegative groups. In women who were HIV-seropositive with normal levels of CRP, a median decrease in Hb of 0.4g/dL was observed. For those with serum CRP levels Ͼ 25 mg/l, the median decrease in Hb was 0.7 g/dL. Results indicate that asymptomatic HIV infection is associated with increased prevalence and severity of anemia in pregnancy in this population.The World Health Organization estimates that at least 50% of pregnant women in Africa are anemic. 1 In sub-Saharan Africa, the prevalence rates reported are between 58% and 75%.

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Section: Discussionmentioning

confidence: 99%

The relationship between asymptomatic human immunodeficiency virus infection and the prevalence and severity of anemia in pregnant Malawian women.

Broek¹,

White²,

Neilson³

1998

The American Journal of Tropical Medicine and Hygiene

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“…In vitro studies have failed to demonstrate a clear constitutive upregulation of these substances, namely, TGF-b, TNF-a and IL-1b in HIV patients. Instead, deficiency of hematopoietic growth factors, such as the stem cell factor (SCF), were observed [46,71].…”

Section: Bone Marrow Microenvironmentmentioning

confidence: 99%

Pathogenesis and pathophysiology of anemia in HIV infection

Kreuzer

Rockstroh

1997

Annals of Hematology

109

100

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Anemia occurs frequently among patients seropositive for human immunodeficiency virus (HIV), but its multifactorial origin complicates its differential diagnosis and adequate treatment. In addition, the etiology of anemia in HIV infection often remains unclear. In recent years several attempts have been undertaken to elucidate the mechanisms leading to HIV-associated anemia. Direct infection of erythroid progenitors has been discussed, but could not be proven. Furthermore, soluble factors like HIV proteins and cytokines have been suggested to inhibit growth of hematopietic cells in the bone marrow of HIV-infected patients. However, so far no statements can be made whether these factors are directly involved in myelosuppression or mediate their effect by inhibiting growth-factor synthesis. Opportunistic complications represent the underlying cause for anemia in a large number of HIV-infected patients. Next to this rather obvious reason for anemia, iatrogenic anemia induced by myelosuppressive drugs is also very common. It is of note, however, that modern dosages of < 600 mg zidovudine (ZDV) daily rarely cause anemia. Instead, other drugs that can induce anemia itself or by enhancing ZDV plasma concentrations must be considered important contributing factors. Deficiency of vitamin B12, folate and iron are frequently reported in HIV patients. However, specific investigations revealed appropriate storage amounts of these micronutrients. Supplementation may be beneficial in some patients, but often fails to reverse anemia in this population. In anemic HIV patients reticulocytopenia is a consistent finding. Additionally, inadequately low endogenous erythropoietin concentrations have been repeatedly reported. Thus, it is speculated that a blunted erythropoietin feedback mechanism contributes substantially to the pathogenesis of anemia in HIV patients.

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“…Since Hamburger et al first reported that BMMSCs produce immuno-cytokines to contribute to the suppression of hematopoiesis ( 36 ), the immunomodulatory effects of MSCs and their underlying mechanisms have been of interest to investigators. In 2005, the first most-cited article innovatively described the phenomenon of MSCs regulating allogeneic immune cells, suggesting that prostaglandin E2 (PGE2) may be an important MSC immunomodulator ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

Global scientific trends on the immunomodulation of mesenchymal stem cells in the 21st century: A bibliometric and visualized analysis

et al. 2022

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BackgroundSince the discovery of the immunomodulatory functions of mesenchymal stem cells (MSCs), their application in immunomodulation has attracted considerable attention, and an increasing number of studies have been conducted worldwide. Our research aimed to investigate the global status and trends in this field.MethodsPublications on the immunomodulatory functions of MSCs from 1 January 2000 to 7 March 2022 were retrieved from the Web of Science Core Collection. The data were studied and indexed using the bibliometric methodology. Visualization analysis, co-authorship, co-occurrence analysis, and publication trends in MSC immunomodulation were conducted using the VOSviewer software.ResultsIn total, 4,227 papers were included in the study. The number of publications and research interests has significantly increased globally. China published the highest number of related articles, while the US published articles with the highest number of citations. Stem Cell Research & Therapy had the highest number of publications. Sun Yat-sen University, Shanghai Jiao Tong University, Harvard University, and Seoul National University were the most contributive institutions. Furthermore, the studies were divided into four research hotspots for MSC immunomodulation: MSC immunomodulation in regenerative medicine, the effects and mechanisms of MSC immunomodulation, MSC therapy for immune diseases, and the cell source of MSCs.ConclusionThis study indicates that the number of publications on MSC immunomodulation will increase in the future, and MSC immunomodulation mechanisms and clinical applications of MSC immunotherapy should be the next hotspots in this research field.

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Impaired cytokine production by bone marrow stromal cells of immunodeficient mice

Cited by 5 publications

References 28 publications

The relationship between asymptomatic human immunodeficiency virus infection and the prevalence and severity of anemia in pregnant Malawian women.

The relationship between asymptomatic human immunodeficiency virus infection and the prevalence and severity of anemia in pregnant Malawian women.

Pathogenesis and pathophysiology of anemia in HIV infection

Global scientific trends on the immunomodulation of mesenchymal stem cells in the 21st century: A bibliometric and visualized analysis

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