Impaired drinking capacity in patients with functional dyspepsia: Relationship with proximal stomach function

Boeckxstaens, Guy E.; Hirsch, David P.; Elzen, B D J van den; Heisterkamp, S. H.; Tytgat, G. N. J.

doi:10.1053/gast.2001.28656

Cited by 162 publications

(205 citation statements)

References 23 publications

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“…7 However, discrepant results have been reported. Maximal tolerated volume measured by both rapid nutrient and water drink tests did not accurately predict impaired accommodation determined by barostat 11 or SPECT. 23 On the other hand, a few studies have demonstrated the association between gastric emptying and maximal tolerated volume by slow NDT.…”

Section: Discussionmentioning

confidence: 77%

“…One study reported a significant correlation between the water drink test and the rapid NDT, whereas another study showed no significant correlation. 9,11 Unlike previous protocols, our drink test protocol used a 500 mL volume of nutrient drink as the fixed standard test volume and quantified the meal-induced dyspeptic symptoms by summing 5 symptom scores. The total aggregate symptom score reflected the dyspeptic symptoms because it correlated significantly with the integrative dyspeptic symptom score.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 It has been performed with various protocols, using water or nutrients. Both water and nutrient drink tests (NDTs) can distinguish patients with FD from normal subjects [7][8][9][10][11][12] and have shown excellent reproducibility. 8,9,13 Recent studies have demonstrated that the results of these tests reflect pharmacological influences.…”

Section: Introductionmentioning

confidence: 99%

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Applying Novel Nutrient Drink to Clinical Trial of Functional Dyspepsia

Lim¹,

Choi²,

Baeg³

et al. 2014

J Neurogastroenterol Motil

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Background/AimsThe drink test has been regarded as a surrogate marker of gastric accommodation. The aims of this study were to develop a novel nutrient drink test (NDT) protocol and investigate its potential for application to a clinical trial of functional dyspepsia (FD). MethodsA novel NDT was designed, involving drinking 125 mL of nutrient 4 times at 5-minute intervals or until maximal tolerability. Healthy volunteers and patients with FD rated their symptoms every 5 minutes for 20 minutes in a developmental study. Patients with FD were enrolled in an open trial of itopride for 4 weeks. NDT was performed before and after treatment. Improvement of integrative symptoms score during NDT after treatment for more than 50% compared with baseline was defined as responder. ResultsTotal aggregate symptom scores, sum of symptom scores measured during NDT, were higher in FD patients (n = 40, 368.1 ± 245.3) than in controls (n = 19, 215.9 ± 171.2) (P = 0.018) in a developmental study. In an open trial of itopride, symptom scores measured during NDT decreased significantly at all time points after treatment in responders (n = 49), whereas did not in non-responders (n = 25). Total aggregate symptom score for NDT correlated significantly with integrative dyspeptic symptom score, sum of 8 symptom scores of NDI questionnaire, at baseline (r = 0.374, P = 0.001) and after treatment (r = 0.480, P ＜ 0.001). ConclusionsOur novel NDT can quantify dyspeptic symptoms and reflected therapeutic effects of itopride treatment in a clinical trial of FD patients. This NDT can be used as an effective parameter in clinical trials or drug development programs for assessing effects of novel therapies on postprandial symptoms.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Applying Novel Nutrient Drink to Clinical Trial of Functional Dyspepsia

Lim¹,

Choi²,

Baeg³

et al. 2014

J Neurogastroenterol Motil

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“…A less invasive water load test has also been used to study the correlation between impaired accommodation and dyspeptic symptoms. Both water loading and nutrient liquid meals can be used to assess accommodation and produce symptoms in approximately 50% of patients with FD (63).…”

Section: Fundal Accommodation and Intragastric Distribution Studiesmentioning

confidence: 99%

“…Such studies have shown that the maximal change in gastric volume (mean, 185%) occurs immediately after meal ingestion and persists despite relatively rapid emptying of the meal (66). Direct comparison of gastric postprandial-to-fasting volume ratios between a balloon barostat and SPECT has shown SPECT to provide an accurate measurement of the accommodation response in healthy and postfundoplication patients (63).…”

Section: Fundal Accommodation and Intragastric Distribution Studiesmentioning

confidence: 99%

Gastrointestinal Motility, Part 1: Esophageal Transit and Gastric Emptying

Maurer

2016

J. Nucl. Med. Technol.

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CE credit: For CE credit, you can access the test for this article, as well as additional JNMT CE tests, online at https://www.snmmilearningcenter.org. Complete the test online no later than March 2019. Your online test will be scored immediately. You may make 3 attempts to pass the test and must answer 80% of the questions correctly to receive 1.0 CEH (Continuing Education Hour) credit. SNMMI members will have their CEH credit added to their VOICE transcript automatically; nonmembers will be able to print out a CE certificate upon successfully completing the test. The online test is free to SNMMI members; nonmembers must pay $15.00 by credit card when logging onto the website to take the test.Although not as well standardized as gastric emptying (GE) scintigraphy, esophageal transit scintigraphy, if performed in a comprehensive manner including both quantitative and qualitative analysis of single-and multiple-swallow studies, is clinically useful when expertise in esophageal manometry is not available or not tolerated and when esophageal manometry or barium videofluoroscopy results are equivocal or nondiagnostic. GE scintigraphy has undergone much-needed standardization. Both solid and liquid GE studies play an important role in assessing patients with upper gastrointestinal symptoms. Because measurement of simple total GE is often not sufficient to explain patient symptoms, there is a need to expand the analysis of GE scintigraphy to include the separate roles of the fundus and antrum and to include the complex interactions the stomach has with other organ systems.

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Gastric interoception and gastric myoelectrical activity in bulimia nervosa and binge‐eating disorder

Dyck

Schulz

Blechert

et al. 2020

Intl J Eating Disorders

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Objective Identifying factors that control food intake is crucial to the understanding and treatment of eating disorders characterized by binge eating. In healthy individuals, stomach distension plays an important role in the development of satiation, but gastric sensations might be overridden in binge eating. The present study investigated the perception of gastric signals (i.e., gastric interoception) and gastric motility in patients experiencing binge‐eating episodes, that is, bulimia nervosa (BN) and binge‐eating disorder (BED). Method Twenty‐nine patients with BN or BED (ED group) and 32 age‐, sex‐, and BMI‐matched healthy controls (HC group) participated in the study. The onset of satiation and stomach fullness were assessed using a novel 2‐step water load test (WLT‐II). Gastric myoelectrical activity (GMA) was measured by electrogastrography (EGG) before and after ingestion of noncaloric water. Results Individuals in the ED group drank significantly more water until reporting satiation during the WLT‐II. The percentage of normal gastric myoelectrical power was significantly smaller in the ED group compared to HC, and negatively related to the number of objective binge‐eating episodes per week in patients with BN or BED. Power in the bradygastria range was greater in ED than in HC participants. Discussion Patients with EDs have a delayed response to satiation compared to HC participants, together with abnormal GMA. Repeated binge‐eating episodes may induce disturbances to gastric motor function.

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Impaired drinking capacity in patients with functional dyspepsia: Relationship with proximal stomach function

Cited by 162 publications

References 23 publications

Applying Novel Nutrient Drink to Clinical Trial of Functional Dyspepsia

Applying Novel Nutrient Drink to Clinical Trial of Functional Dyspepsia

Gastrointestinal Motility, Part 1: Esophageal Transit and Gastric Emptying

Gastric interoception and gastric myoelectrical activity in bulimia nervosa and binge‐eating disorder

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