Impaired endothelial function and insulin action in first-degree relatives of patients with type 2 diabetes mellitus

Sonne, Mette P.; Højbjerre, Lise; Alibegovic, Amra Ciric; Vaag, Allan; Stallknecht, Bente; Dela, Flemming

doi:10.1016/j.metabol.2008.08.011

Cited by 14 publications

(16 citation statements)

References 38 publications

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“…However, the predominant effect is a training-induced enhancement of leg blood flow (16,21), as also found in CON, but not in FDR, in the present study. The latter observation is in accord with recent findings of diminished insulin-mediated forearm blood flow in FDR (50).…”

Section: Insulin Actionsupporting

confidence: 92%

Effect of physical training on insulin secretion and action in skeletal muscle and adipose tissue of first-degree relatives of type 2 diabetic patients

Dela

Stallknecht

2010

American Journal of Physiology-Endocrinology and Metabolism

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Dela F, Stallknecht B. Effect of physical training on insulin secretion and action in skeletal muscle and adipose tissue of firstdegree relatives of type 2 diabetic patients. Am J Physiol Endocrinol Metab 299: E80 -E91, 2010. First published April 20, 2010; doi:10.1152/ajpendo.00765.2009.-Physical training affects insulin secretion and action, but there is a paucity of data on the direct effects in skeletal muscle and adipose tissue and on the effect of training in first-degree relatives (FDR) of patients with type 2 diabetes. We studied insulin action at the whole body level and peripherally in skeletal muscle and adipose tissue as well as insulin-secretory capacity in seven FDR and eight control (CON) subjects before and after 12 wk of endurance training. Training improved physical fitness. Insulinmediated glucose uptake (GU) increased (whole body and leg; P Ͻ 0.05) after training in CON but not in FDR, whereas glucose-mediated GU increased (P Ͻ 0.05) in both groups. Adipose tissue GU was not affected by training, but it was higher (abdominal, P Ͻ 0.05; femoral, P ϭ 0.09) in FDR compared with CON. Training increased skeletal muscle lipolysis (P Ͻ 0.05), and it was markedly higher (P Ͻ 0.05) in subcutaneous abdominal than in femoral adipose tissue and quadriceps muscle with no difference between FDR and CON. Glucosestimulated insulin secretion was lower in FDR compared with CON, but no effect of training was seen. Glucagon-like peptide-1 stimulated insulin secretion five-to sevenfold. We conclude that insulin-secretory capacity is lower in FDR than in CON and that there is dissociation between training-induced changes in insulin secretion and insulin-mediated GU. Maximal GU rates are similar between groups and increases with physical training.glucagon-like peptide-1; hyperglycemic clamp; blood flow; intravenous glucose tolerance test; hyperinsulinemic euglycemic clamp; microdialysis; arteriovenous balance PHYSICAL TRAINING IS A CORNERSTONE in the initial treatment of patients with type 2 diabetes. In skeletal muscle, the insulinsensitizing effect of training in both healthy individuals and patients with type 2 diabetes is well documented (6,8,10,34,46). In individuals with a genetic predisposition for type 2 diabetes, first-degree relatives (FDR) of patients with type 2 diabetes, only a few training studies have been carried out, and none have directly examined the effect of physical training on insulin sensitivity in skeletal muscle and adipose tissue. In one study in a mixed group of FDR males and females, training enhanced insulin-mediated whole body glucose uptake rates (40), but there was no correlation between glucose uptake and measures of fitness [maximal oxygen uptake (V O 2max )]. In a recent study in females (3), a training-induced increase in whole body insulin sensitivity was found only in FDR subjects, yet this could not be demonstrated in control subjects (CON) despite similar increases in V O 2max in the two groups.

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Section: Insulin Actionsupporting

confidence: 92%

Effect of physical training on insulin secretion and action in skeletal muscle and adipose tissue of first-degree relatives of type 2 diabetic patients

Dela

Stallknecht

2010

American Journal of Physiology-Endocrinology and Metabolism

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“…This association may be explained by the fact that insulin resistance is associated with reduced nitric oxide (NO) bioavailability [21e23] that regulates local arterial distensibility [22] and coronary microcirculatory response to hyperemia [14]. Furthermore, hyperinsulinemia may contribute to the proliferation of arterial smooth muscle cells [1] leading to alterations of arterial wall properties. Indeed, in our study, fasting and peak insulin levels during OGTT were twice as higher in FDR than those in normoglycaemic subjects and similar to those in dysglycaemic subjects.…”

Section: Arterial Wall Properties In Fdrmentioning

confidence: 99%

“…Subclinical states of insulin resistance namely impaired glucose tolerance as well as being a first-degree relative (FDR) of a type 2 diabetic patient are considered predisposing factors for vascular disease [1,2].…”

Section: Introductionmentioning

confidence: 99%

Insulin resistance and acute glucose changes determine arterial elastic properties and coronary flow reserve in dysglycaemic and first-degree relatives of diabetic patients

et al. 2015

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“…It has been revealed that several metabolic defects may exist in normal glucose-tolerant first-degree relatives (FDR) of patients with T2DM [3]. Whole-body insulin resistance and decreased forearm glucose uptake have been shown in normoglycaemic FDR [4]. Decreased second-phase insulin release has also been shown in normal glucose-tolerant FDR [5].…”

Section: Introductionmentioning

confidence: 99%

Fıbroblast growth factor 21 and ıts relatıonshıp wıth ınsulın sensıtıvıty ın fırst-degree relatıves of patıents wıth type 2 dıabetes mellıtus

Ors

Altınova

Yalcin

et al. 2015

Endokrynologia Polska

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Impaired endothelial function and insulin action in first-degree relatives of patients with type 2 diabetes mellitus

Cited by 14 publications

References 38 publications

Effect of physical training on insulin secretion and action in skeletal muscle and adipose tissue of first-degree relatives of type 2 diabetic patients

Effect of physical training on insulin secretion and action in skeletal muscle and adipose tissue of first-degree relatives of type 2 diabetic patients

Insulin resistance and acute glucose changes determine arterial elastic properties and coronary flow reserve in dysglycaemic and first-degree relatives of diabetic patients

Fıbroblast growth factor 21 and ıts relatıonshıp wıth ınsulın sensıtıvıty ın fırst-degree relatıves of patıents wıth type 2 dıabetes mellıtus

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