Impaired endothelial function following a meal rich in used cooking fat

Williams, Michael J.A.; Sutherland, W. H. F.; McCormick, M. P.; Jong, Sylvia A. de; Walker, Robert; Wilkins, Gerard T.

doi:10.1016/s0735-1097(98)00681-0

Cited by 172 publications

(127 citation statements)

References 26 publications

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“…NO production from healthy endothelial cells has an antiatherogenic effect by inhibiting cellular adhesion, migration, and proliferation responses involved in early lesion formation. 5,6 Transient reductions in endothelial function have previously been reported after a high fat meal, 25 in drug-induced hyperhomocysteinemia, 26 and in the inflammatory response to vaccination 27 and might contribute to the pathogenesis of atherosclerosis. Studies in the cynomolgus monkey have shown that chronic social conflict increases the rate of endothelial cell damage 12 and reduces NO bioavailability in the coronary arteries.…”

Section: Discussionmentioning

confidence: 96%

Mental Stress Induces Transient Endothelial Dysfunction in Humans

et al. 2000

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Background —Mental stress has been linked to increased morbidity and mortality in coronary artery disease and to atherosclerosis progression. Experimental studies have suggested that damage to the endothelium may be an important mechanism. Methods and Results —Endothelial function was studied in 10 healthy men (aged 50.4±9.6 years) and in 8 non–insulin-dependent diabetic men (aged 52.0±7.2 years). Brachial artery flow-mediated dilation (FMD, endothelium dependent) and response to 50 μg of sublingual glyceryl trinitrate (GTN, endothelium independent) were measured noninvasively by use of high-resolution ultrasound before and after (30, 90, and 240 minutes) a standardized mental stress test. The same protocol without mental stress was repeated on a separate occasion in the healthy men. In healthy subjects, FMD (5.0±2.1%) was significantly ( P <0.01) reduced at 30 and 90 minutes after mental stress (2.8±2.3% and 2.3±2.4%, respectively) and returned toward normal after 4 hours (4.1±2.0%). Mental stress had no effect on the response to GTN. In the repeated studies without mental stress, FMD did not change. The diabetic subjects had lower FMD than did the control subjects (3.0±1.5% versus 5.0±2.1%, respectively; P =0.02) but showed no changes in FMD (2.7±1.1% after 30 minutes, 2.8±1.9% after 90 minutes, and 3.1±2.3% after 240 minutes) or GTN responses after mental stress. Conclusions —These findings suggest that brief episodes of mental stress, similar to those encountered in everyday life, may cause transient (up to 4 hours) endothelial dysfunction in healthy young individuals. This might represent a mechanistic link between mental stress and atherogenesis.

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Section: Discussionmentioning

confidence: 96%

Mental Stress Induces Transient Endothelial Dysfunction in Humans

et al. 2000

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“…Frying can greatly alter a fish meal's nutrient composition, increasing contents of n-6 fatty acids, trans-fatty acids, and oxidation products, particularly when oils are used repeatedly for frying. [35][36] Adjustment for baseline coronary heart disease, left ventricular systolic function, blood pressure, treated hypertension, and C-reactive protein levels attenuated the higher AF risk seen with fried fish/fish sandwich intake, which suggests that these factors may in part confound or mediate the association. Further investigation is necessary to confirm these observations, determine if they are specific for certain kinds of fish or frying oils, and examine potential mechanisms and alternative explanations.…”

Section: Discussionmentioning

confidence: 99%

Fish Intake and Risk of Incident Atrial Fibrillation

et al. 2004

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Background-Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is particularly common in the elderly. Although effects of fish intake, including potential antiarrhythmic effects, may favorably influence risk of AF, relationships between fish intake and AF incidence have not been evaluated. Methods and Results-In a prospective, population-based cohort of 4815 adults Նage 65 years, usual dietary intake was assessed at baseline in 1989 and 1990. Consumption of tuna and other broiled or baked fish correlated with plasma phospholipid long-chain n-3 fatty acids, whereas consumption of fried fish or fish sandwiches (fish burgers) did not. AF incidence was prospectively ascertained on the basis of hospital discharge records and annual electrocardiograms. During 12 years' follow-up, 980 cases of incident AF were diagnosed. In multivariate analyses, consumption of tuna or other broiled or baked fish was inversely associated with incidence of AF, with 28% lower risk with intake 1 to 4 times per week (HRϭ0.72, 95% CIϭ0.58 to 0.91, Pϭ0.005), and 31% lower risk with intake Ն5 times per week (HRϭ0.69, 95% CIϭ0.52 to 0.91, Pϭ0.008), compared with Ͻ1 time per month (P trendϭ0.004). Results were not materially different after adjustment for preceding myocardial infarction or congestive heart failure. In similar analyses, fried fish/fish sandwich consumption was not associated with lower risk of AF. Conclusions-Among elderly adults, consumption of tuna or other broiled or baked fish, but not fried fish or fish sandwiches, is associated with lower incidence of AF. Fish intake may influence risk of this common cardiac arrhythmia.

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“…This might, at least in part, be due to important distinctions between various antioxidants, i.e., their ability to quench free radical activity, and their localization within the vascular wall. However, mechanistic study of chronic uric acid elevation may prove more of a challenge, and the current study design appears to be a valid approach because acute elevation of established major cardiovascular risk factors causes impaired endothelial function in healthy individuals, i.e., after ingestion of a meal rich in saturic acid fats (41) or after raising circulating homocysteine concentrations by oral methionine administration (42). Assessment of endothelial function as a risk marker appears valid because of correlations between short-and long-term effects of interventions that are known to be effective in reducing cardiovascular risk, i.e., blood pressure lowering and statin therapy (43,44).…”

Section: Discussionmentioning

confidence: 99%

Uric Acid Restores Endothelial Function in Patients With Type 1 Diabetes and Regular Smokers

et al. 2006

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Endothelial dysfunction is a characteristic finding in both patients with type 1 diabetes and in regular smokers and is an important precursor to atherosclerosis. The urate molecule has antioxidant properties, which could influence endothelial function. The impact of acutely raising uric acid concentrations on endothelial function was studied in eight men with type 1 diabetes, eight healthy regular smokers, and eight age-matched healthy control subjects in a randomized, four-way, double-blind, placebo-controlled study. Subjects received 1,000 mg uric acid i.v. in vehicle, 1,000 mg vitamin C as a control antioxidant, vehicle alone, or 0.9% saline on separate occasions over 1 h. Forearm blood flow responses to intrabrachial acetylcholine and sodium nitroprusside were assessed using venous occlusion plethysmography. Responses to acetylcholine, but not sodium nitroprusside, were impaired in patients with diabetes (P < 0.001) and in smokers (P < 0.005) compared with control subjects. Administration of uric acid and vitamin C selectively improved acetylcholine responses in patients with type 1 diabetes (P < 0.01) and in regular smokers (P < 0.05). Uric acid administration improved endothelial function in the forearm vascular bed of patients with type 1 diabetes and smokers, suggesting that high uric acid concentrations in vivo might serve a protective role in these and other conditions associated with increased cardiovascular risk. Diabetes 55:3127-3132, 2006

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Impaired endothelial function following a meal rich in used cooking fat

Abstract: Ingestion of a meal rich in fat previously used for deep frying in a commercial fast food restaurant resulted in impaired arterial endothelial function. These findings suggest that intake of degradation products of heated fat contribute to endothelial dysfunction.

Cited by 172 publications

References 26 publications

Mental Stress Induces Transient Endothelial Dysfunction in Humans

Mental Stress Induces Transient Endothelial Dysfunction in Humans

Fish Intake and Risk of Incident Atrial Fibrillation

Uric Acid Restores Endothelial Function in Patients With Type 1 Diabetes and Regular Smokers

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