2024
DOI: 10.1101/2024.10.25.620248
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Impaired erythroid maturation in murine embryos upon loss of the preeclampsia-associated serine protease prostasin

Sara Di Carlo,
Adrian Salas-Bastos,
Mariela Castelblanco Castelblanco
et al.

Abstract: In humans, the membrane-bound serine protease prostasin encoded by Prss8 is associated with preeclampsia, a gestational hypertension disorder affecting blood supply of the placenta. Mice deficient in Prss8 resulted in the death of embryos at embryonic day (E) 14.5 and it was characterized by impaired placental labyrinth maturation and vascularization. A pale phenotype was observed in these embryos, suggesting ineffective erythropoiesis. Thus, in this study we analyzed this phenotype further in Prss8-/- embryos… Show more

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