Impaired Fasting Glucose & 8-Iso-Prostaglandin F2α in Diabetes Disease Progression

Abstract

Aims: The objective of the present study was to evaluate the changes of 8-isoprostaglandin F 2α and other markers of oxidative stress with impaired fasting glucose when compared to non-diabetic control participants. Methodology: This is a cross-sectional study, conducted at Charles Sturt University, Albury, NSW, Australia and included 428 participants (female: male, 247:181) participants attending the Diabetes Complications Clinic in the School of Community Health for the period between January 2011 to October 2012. Results: Urinary 8-isoprostaglandin F 2α was significantly greater in the impaired fasting glucose group (1.4±1.3ng/ml) compared to control group (0.68±0.5ng/ml, P= .05). The increase in urinary 8-isoprostaglandin F 2α was associated with a significant elevation in serum total cholesterol (4.7±1.1mol/L, P= .04) and a significant reduction in high density lipoprotein cholesterol (1.4±0.4mmol/L, P= .02) in the impaired fasting glucose group compared to the control group. A significant negative correlation was noted between urinary 8-isoprostaglandin F 2α and high-density lipoprotein cholesterol among all the participants included in this study (P= .05). Original Research ArticleBritish Journal of Medicine & Medical Research, 4(33): 5229-5237, 2014 5230 Conclusions: The current study proves the importance of measuring markers of oxidative stress, expressed by urinary 8-isoprostaglandin F 2α and serum lipids in managing cases of impaired fasting glucose and suggests a useful biomarker for assessing disease progression and/or remission, especially in the prediabetic state.

The Activity of Serum 8-Iso-Prostaglandin F2<i>α</i> as Oxidative Stress Marker in Patients with Diabetes Mellitus Type 2 and Associated Dyslipidemic Hyperglycemia

“…A clinical study performed by Bandeira and coworkers [36] was demonstrated in diabetic patients of our study and a significant association was recorded with 8-iso-PGF2α. Serum lipids showed significant elevation in diabetic patients (p < 0.0001) but in HDL-C, a significant decrease (p = 0.04) was recorded confirming other reports [32] demonstrated a significant reduction in both total cholesterol and HDL-C which explains the increased 8-iso-PGF2α as HDL-C caries 8-iso-PGF2α [10].…”

“…Jelinek et al [32] demonstrated a significant increase in 8-iso-PGF2α in the IFG group and supports the findings that, 8-iso-PGF2α was increased following an oral glucose tolerance in individuals with no diabetes but with either IFG or impaired glucose tolerance [33]. 8-iso-PGF2α was elevated in the sera of diabetic patients (2719.38 ± 1864.68 pg/ml) in current study compared with non-diabetic control (951.45 ± 669.44 pg/ml, p < 0.0001).…”

Data-analytically derived flexible HbA1c thresholds for type 2 diabetes mellitus diagnostic

“…19.4% of the control group used statins compared with 37.5% of the IFG group." Another study using a sample of the DiScRi data actually acknowledges the TC level reduction: [62] "Both total cholesterol and HDL-C were significantly lower in the IFG group, while triglycerides and LDL-C showed no difference between the groups." It was also noted that ".…”

Inflammation and oxidative stress markers in diabetes and hypertension

“…Urinary excretion of 8-iso-PGF 2 α has been found to be higher in hypertensive and diabetic patients when compared to healthy controls. 16 , 20 The increase in urinary 8-iso-PGF 2 α is associated with elevation of serum total cholesterol (TC) and reduction of high-density lipoprotein cholesterol (HDL-C) that can lead to atherosclerosis and coronary heart disease. 20 Hypertensive and normotensive diabetic patients have similar urinary 8-iso-PGF 2 α excretion, suggesting similar mechanisms with respect to glycemic control, lipid peroxidation, and antioxidation mechanisms.…”

“… 16 , 20 The increase in urinary 8-iso-PGF 2 α is associated with elevation of serum total cholesterol (TC) and reduction of high-density lipoprotein cholesterol (HDL-C) that can lead to atherosclerosis and coronary heart disease. 20 Hypertensive and normotensive diabetic patients have similar urinary 8-iso-PGF 2 α excretion, suggesting similar mechanisms with respect to glycemic control, lipid peroxidation, and antioxidation mechanisms. 21 , 22 Atherosclerosis is associated with HTN and is characterized by oxidative stress and pro-inflammatory activity that may be associated with the observed imbalance between coagulation and fibrinolysis.…”