Impaired fasting glucose and the metabolic profile in Danish children and adolescents with normal weight, overweight, or obesity

Kloppenborg, Julie Tonsgaard; Fonvig, Cilius Esmann; Nielsen, Tenna Ruest Haarmark; Mollerup, Pernille Maria; Bøjsøe, Christine; Pedersen, Oluf; Johannesen, Jesper; Hansen, Torben; Holm, Jens Christian

doi:10.1111/pedi.12604

Cited by 23 publications

(25 citation statements)

References 49 publications

(109 reference statements)

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“…On the other hand, adiposity (measured by BMI‐for‐age and waist‐to‐hip ratio) showed strong independent association with prediabetes. This association has been demonstrated throughout previous scientific reports; hence, further highlighting the criticalness of adiposity in the development of prediabetes and subsequent progression to T2DM.…”

Section: Discussionsupporting

confidence: 76%

“…Among children and adolescents, family history of diabetes, representing inherited genetic susceptibility and shared predisposing environment, and adiposity, inducing insulin resistance, are major risk factors for prediabetes and T2DM development. [15][16][17][18] To this end, in Kuwait, it has been estimated that overweight and obesity affect 21.6% and 30.5% of children aged 6 to 18 years, respectively. 19 On the other hand, the prevalence of diabetes in Kuwait has been estimated to be 23.1% among adults, placing Kuwait among the top 10 highest prevalence countries worldwide.…”

Section: Nevertheless Lifestyle Changes and Pharmacological Intervenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations of adiposity and parental diabetes with prediabetes among adolescents in Kuwait: A cross‐sectional study

Almari

Al-Saedi²,

Mohammad

et al. 2018

Pediatr Diabetes

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Background Prediabetes, a high‐risk state for developing diabetes, has become more prevalent among children and adolescents in recent decades. This study sought to estimate the prevalence of prediabetes and assess its association with adiposity among adolescents in Kuwait. Also, to determine whether maternal and paternal history of diabetes associate with offspring prediabetes in a sex‐specific manner. Methods A cross‐sectional study was conducted by enrolling students (n = 1959; aged 14‐19 years) attending high schools across Kuwait. Body mass index‐for‐age z‐scores were estimated using the World Health Organization growth reference. Glycated hemoglobin A1c (HbA1c) was measured in capillary blood using point‐of‐care testing. Prediabetes was defined according to the diagnostic criteria of the American Diabetes Association (ADA; 5.7 ≤ HbA1c% ≤ 6.4) and the International Expert Committee (IEC; 6.0 ≤ HbA1c% ≤ 6.4). Adjusted prevalence ratios (aPR) and 95% confidence intervals (CI) were estimated using Poisson regression with robust variance estimation. Results According to the ADA criteria, 33.3% (620/1845) of participants had prediabetes; whereas, 8.5% (157/1845) met the IEC definition for prediabetes. Subjects classified as obese had higher prevalence of prediabetes compared to children in the thinness/normal group (aPR = 1.68, 95% CI: 1.44‐1.95). Analysis stratified by offspring sex showed that maternal history of diabetes is associated with prediabetes among male offspring (aPR = 1.29, 95% CI: 1.02‐1.63). In contrast, paternal history of diabetes showed an association with prediabetes among female offspring (aPR = 1.22, 95% CI: 1.01‐1.48). Conclusions Prediabetes affects a substantial proportion of adolescents in Kuwait and adiposity and parental diabetes being the main associated factors with prediabetes.

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Section: Discussionsupporting

confidence: 76%

Section: Nevertheless Lifestyle Changes and Pharmacological Intervenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations of adiposity and parental diabetes with prediabetes among adolescents in Kuwait: A cross‐sectional study

Almari

Al-Saedi²,

Mohammad

et al. 2018

Pediatr Diabetes

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“…25,27 Obesity is associated with several comorbidities in adolescents and young adults. 28,29 In our series, all of our patients with T2D had complete resolution without medications and one out of two for hypertension, similar to the outcomes reported by others. 10,30,31 One patient with obstructive sleep apnea improved symptomatically after SG; however, he did not undergo objective assessment.…”

Section: Discussionsupporting

confidence: 87%

Laparoscopic Sleeve Gastrectomy for Morbid Obesity in Kuwaiti Adolescents

KhoursheedMousa

Al-BaderIbtisam

Mouzannar

et al. 2019

Bariatric Surgical Practice and Patient Care

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Background: Bariatric surgery has superior therapeutic outcomes compared with other existing treatments. Our aim was to evaluate the safety and efficacy of laparoscopic sleeve gastrectomy (SG) in adolescents with obesity. Methods: From February 2012 until March 2018, all adolescents who underwent SG for obesity were analyzed. Demographics were evaluated. The main outcomes measured were change in weight, body mass index (BMI), percentage excess weight loss (%EWL), complications, and reoperations. Results: Twenty-two adolescents (16/6, F/M) underwent SG. Mean age, preoperative weight, and BMI were 16.4-2.1 years, 125.0-30.2 kg, and 45.1-8.1 kg/m 2 , respectively. The mean duration of operation and hospital stay were 54.7-3.9 min and 2-0 days, respectively. The median follow-up was 9 months. The mean weight loss, BMI loss, and %EWL were 36.4-31.8 kg, 13.8-10.5 kg/m 2 , and 50.9%-27.1%, respectively. One patient developed transient vitamin deficiency due to repeated vomiting. Two patients with type 2 diabetes mellitus had complete remission without medications. Conclusions: SG is effective and safe to treat obesity in adolescents. Further studies are needed to evaluate the long-term effects of SG in adolescents.

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“…Alterations in glucose metabolism are important in the development of metabolic and cardiovascular disease and may occur already in childhood. With the presence of childhood obesity, these alterations become increasingly common . Although the prevalence of type 2 diabetes in children and adolescents is less than 1%, the prevalence is estimated to quadruple by 2050, mainly driven by the rising obesity rates while prediabetes is already common …”

Section: Introductionmentioning

confidence: 99%

Glucose metabolism in children and adolescents: Population‐based reference values and comparisons to children and adolescents enrolled in obesity treatment

et al. 2019

Self Cite

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Background: Alterations in glucose metabolism that lead to the development of metabolic and cardiovascular disease may begin already in childhood.Objective: This study aims to generate pediatric age and sex-specific reference values for fasting concentrations of glucose, hemoglobin A1c (HbA1c), insulin, C-peptide, and homeostasis model assessment: insulin resistance (HOMA-IR) in Danish/North-European white children and adolescents from a population-based cohort and to compare values from children and adolescents with overweight/obesity with this reference. Methods:The population-and obesity clinic-based cohorts consisted of 2451 and 1935 children and adolescents between 6 and 18 years of age. Anthropometric measurements and blood samples were obtained and percentile curves were calculated.Results: In the population-based cohort, glucose, insulin, and HOMA-IR values increased before the expected onset of puberty (P < .05). Thereafter, all variables decreased in girls (P < .05) and HbA1c decreased in boys (P < .05). Concentrations of Abbreviations: BMI, body mass index; CV, coefficient of variation; DL, detection limits; HOMA-IR, homeostasis model assessment: insulin resistance; SDS, standard deviation score.

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Impaired fasting glucose and the metabolic profile in Danish children and adolescents with normal weight, overweight, or obesity

Cited by 23 publications

References 49 publications

Associations of adiposity and parental diabetes with prediabetes among adolescents in Kuwait: A cross‐sectional study

Associations of adiposity and parental diabetes with prediabetes among adolescents in Kuwait: A cross‐sectional study

Laparoscopic Sleeve Gastrectomy for Morbid Obesity in Kuwaiti Adolescents

Glucose metabolism in children and adolescents: Population‐based reference values and comparisons to children and adolescents enrolled in obesity treatment

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