Impaired flow-mediated vasoactivity during post-prandial phase in young healthy men

Marchesi, Simona; Lupattelli, Graziana; Schillaci, Giuseppe; Pirro, Matteo; Siepi, Donatella; Roscini, Anna Rita; Pasqualini, Leonella

doi:10.1016/s0021-9150(00)00415-9

Cited by 128 publications

(153 citation statements)

References 26 publications

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“…In agreement with results of others (Marchesi et al, 2000;Vogel et al, 2000) we found that changes in serum triacylglycerols showed a negative correlation with changes in FMD, although statistically significant for saturated fatty acids only. This result appears to contradict our finding that FMD was slightly higher 3 h after the meals, when serum triacylglycerols were higher, than before the meals.…”

Section: Correlation Between Changes In Serum Triacylglycerols and Flsupporting

confidence: 93%

“…Studies that showed an impairment of FMD by an oral fat load used similar doses of fat (0.9 -1.0 g=kg bodyweight) and study designs (measurements fasting and 3 -4 h postprandially) to ours (Table 1). We mixed the test fats with a milkshake, as was done by others Vogel et al, 1997;Marchesi et al, 2000). The test meals were consumed under our supervision, and therefore non-compliance could not explain the unexpected outcome of the study.…”

Section: Discussionmentioning

confidence: 99%

“…Maybe the increase in serum triacylglycerols in our study was too small to counteract such a diurnal variation in FMD; the increase 3.5 h after the meals was moderate, with 0.46 mmol=l after the sat-meal and 0.68 mmol=l after the trans meal. However, many studies that did show an effect on FMD reported similar increases in serum triacylglycerols within the same time frame (Marchesi et al, 2000;Djoussé et al, 1999;Plotnick et al, 1997;Williams et al, 1999).…”

Section: Correlation Between Changes In Serum Triacylglycerols and Flmentioning

confidence: 92%

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Trans monounsaturated fatty acids and saturated fatty acids have similar effects on postprandial flow-mediated vasodilation

et al. 2002

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Objective: Several studies suggest that a fatty meal impairs flow-mediated vasodilation (FMD), a measure of endothelial function. We tested whether the impairment was greater for trans fats than for saturated fats. We did this because we previously showed that replacement of saturated fats by trans fats in a controlled diet decreased FMD after 4 weeks. Design: We fed 21 healthy men two different test meals with 0.9 -1.0 g fat=kg body weight in random order: one rich in saturated fatty acids (Sat), mainly from palm kernel fat, and one rich in trans fatty acids (Trans) from partially hydrogenated soy bean oil. The study was performed in our metabolic ward. We had complete data for both diets of 21 men. Results: FMD increased from a fasting value of 2.3 AE 2.0% of the baseline diameter to 3.0 AE 1.7% after the Sat test meal (95% CI for change 7 0.33, 1.70) and from 2.7 AE 2.3 to 3.1 AE 2.0% after the Trans test meal (95% CI for change 7 0.57, 1.29). The increase after the Sat meal was 0.22 ( 7 1.18 -1.61) FMD% higher than after the Trans meal. Serum triacylglycerols increased by 0.46 AE 0.36 mmol=l after the Sat test meal and by 0.68 AE 0.59 mmol=l after the Trans test meal; a difference of 0.23 (0.07, 0.39) mmol=l. Serum HDL-cholesterol was hardly affected by the test meals. The activity of serum paraoxonase, an esterase bound to HDL, increased slightly after the two test meals but the difference between meals was not significant. Conclusion: FMD was not impaired and not different after test meals with saturated or trans fatty acids. Thus, differences in long-term effects of these fats are not caused by differences in acute effects on the vascular wall.

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Section: Correlation Between Changes In Serum Triacylglycerols and Flsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Correlation Between Changes In Serum Triacylglycerols and Flmentioning

confidence: 92%

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Trans monounsaturated fatty acids and saturated fatty acids have similar effects on postprandial flow-mediated vasodilation

et al. 2002

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“…In order to minimise ar- terial line complications and to not miss the meal response in the non-diabetic group we measured EDV 3 hours after the meal, the time point at which the postprandial triglycerides would have increased to the greatest extent but would not have peaked in the diabetic group [23,27,40]. Data from studies measuring EDV once in 3 hours, or serially after a meal challenge suggests that endothelial impairment occurs within 3 hours in healthy volunteers [25,26,28,39,40] and patients with Type 2 diabetes [27,29] at similar or lower postprandial triglyceride elevations than in our study. It is therefore unlikely that we missed the effect of postprandial lipid excursions on endothelial function in the diabetic group due to the timing of EDV measurements.…”

Section: Study Limitationsmentioning

confidence: 99%

The postprandial state does not impair endothelial function in women with Type 2 diabetes irrespective of glycaemic control

et al. 2004

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Aims/hypothesis. The postprandial state has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In Type 2 diabetes, postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved glycaemic control on endothelial function in the postprandial state. Methods. We studied 19 postmenopausal women with Type 2 diabetes and ten non-diabetic subjects. Participants with diabetes were re-studied 3 months after intensive glucose regulation. We measured forearm blood flow by strain gauge plethysmography during rest, during acetylcholine infusion and post ischaemia in the fasting state, and again 3 hours after a mixed meal (660 kcal, 55% fat). Results. Endothelium-dependent vasodilation was impaired in the diabetic group (p<0.005) and improved following an HbA 1 c reduction of 0.96% (p<0.05 for high-dose acetylcholine infusion). Postprandial metabolic excursions were higher in the diabetic group (p<0.001, p<0.01 and p<0.05 for glucose, insulin and triglycerides respectively). Resting forearm blood flow increased in all groups after the meal (p<0.005). There was no difference in fasting and postprandial endothelium-dependent vasodilation before and after improved glucose regulation in either group. Conclusions/interpretation. The postprandial state does not impair endothelial function in non-diabetic women and does not make pre-existing endothelial dysfunction worse in women with Type 2 diabetes, irrespective of glycaemic control.

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“…With regard to the acute effect of hyperglycaemia on endothelium-dependent vasodilatation (EDV), conflicting results have been reported in vivo in humans, with some describing a neutral or a very mild and short-lasting effect [16][17][18][19][20][21] and others a negative impact [22][23][24][25][26]. Part of this heterogeneity can be ascribed to differences in the vascular district investigated (large, small or micro-vessels), the experimental technique adopted and the stimulus applied.…”

Section: Introductionmentioning

confidence: 99%

Effects of glucose tolerance on the changes provoked by glucose ingestion in microvascular function

et al. 2008

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Aims/hypothesis Hyperglycaemia and hyperinsulinaemia have opposite effects on endothelium-dependent vasodilatation in microcirculation, but the net effect elicited by glucose ingestion and the separate influence of glucose tolerance are unknown. Methods In participants with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) or diabetic glucose tolerance, multiple plasma markers of both oxidative stress and endothelial activation, and forearm vascular responses (plethysmography) to intra-arterial acetylcholine (ACh) and sodium nitroprusside (SNP) infusions were measured before and after glucose ingestion. In another IGT group, we evaluated the time-course of the skin vascular responses (laser Doppler) to ACh and SNP (by iontophoresis) 1, 2 and 3 h into the OGTT; the plasma glucose profile was then reproduced by means of a variable intravenous glucose infusion and the vascular measurements repeated. Results Following oral glucose, plasma antioxidants were reduced by 5% to 10% (p<0.01) in all patient groups. The response to acetylcholine was not affected by glucose ingestion in any group, while the response to SNP was attenuated, particularly in the IGT group. The ACh:SNP ratio was slightly improved therefore in all groups, even in diabetic participants, in whom it was impaired basally. A time-dependent improvement in ACh:SNP ratio was also observed in skin microcirculation following oral glucose; this improvement was blunted when matched hyperglycaemia was coupled with lower hyperinsulinaemia (intravenous glucose). Conclusions/interpretation Regardless of glucose tolerance, oral glucose does not impair endothelium-dependent vasodilatation either in resistance arteries or in the microcirculation, despite causing increased oxidative stress; the endogenous insulin response is probably responsible for countering any inhibitory effect on vascular function.

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Impaired flow-mediated vasoactivity during post-prandial phase in young healthy men

Cited by 128 publications

References 26 publications

Trans monounsaturated fatty acids and saturated fatty acids have similar effects on postprandial flow-mediated vasodilation

Trans monounsaturated fatty acids and saturated fatty acids have similar effects on postprandial flow-mediated vasodilation

The postprandial state does not impair endothelial function in women with Type 2 diabetes irrespective of glycaemic control

Effects of glucose tolerance on the changes provoked by glucose ingestion in microvascular function

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