2014
DOI: 10.1016/j.neuroimage.2014.05.016
|View full text |Cite
|
Sign up to set email alerts
|

Impaired functional organization in the visual cortex of muscarinic receptor knock-out mice

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
16
0

Year Published

2014
2014
2023
2023

Publication Types

Select...
7
1

Relationship

2
6

Authors

Journals

citations
Cited by 20 publications
(18 citation statements)
references
References 78 publications
2
16
0
Order By: Relevance
“…The differential action of ACh on lateral connections might simultaneously enhance specific modules of the same orientation (lateral correlation) while depressing adjacent irrelevant modules (McGuire et al, 1991; Stettler et al, 2002). A recent study using optogenetics showed that inhibition of the intracortical excitatory neurons leads to a receptive field reduction (Li et al, 2013), and this finding is consistent with the effect of ACh release in V1 (Roberts et al, 2005; Zinke et al, 2006) and the increases in the population receptive fields of M1/M3 mAChR knock-out mice (Groleau et al, 2014). Furthermore, an ACh esterase inhibitor reduces surround suppression in a perceptual study in humans (Kosovicheva et al, 2012), which could be indicative of a weakening of lateral connections.…”
Section: Acetylcholine Modulates the Flow Of Visual Information In V1supporting
confidence: 57%
See 1 more Smart Citation
“…The differential action of ACh on lateral connections might simultaneously enhance specific modules of the same orientation (lateral correlation) while depressing adjacent irrelevant modules (McGuire et al, 1991; Stettler et al, 2002). A recent study using optogenetics showed that inhibition of the intracortical excitatory neurons leads to a receptive field reduction (Li et al, 2013), and this finding is consistent with the effect of ACh release in V1 (Roberts et al, 2005; Zinke et al, 2006) and the increases in the population receptive fields of M1/M3 mAChR knock-out mice (Groleau et al, 2014). Furthermore, an ACh esterase inhibitor reduces surround suppression in a perceptual study in humans (Kosovicheva et al, 2012), which could be indicative of a weakening of lateral connections.…”
Section: Acetylcholine Modulates the Flow Of Visual Information In V1supporting
confidence: 57%
“…Moreover, ACh release might be triggered by local neuronal activity to induce locally restricted rather than generalized action of the cholinergic system (Laplante et al, 2005). The variety of the cholinergic receptors and their distributions convey subtype-specific functions (Thiele, 2013; Groleau et al, 2014). In V1, AChRs exhibit differential subtype densities across the cortical layers (I-VI) on both excitatory (Gulledge et al, 2009; Thiele, 2013) and inhibitory neurons (Hashimoto et al, 1994).…”
Section: Organization Of the Cholinergic System In V1mentioning
confidence: 99%
“…This change in neuron properties is due to improved neuronal sensitivity resulting from a change in membrane conductance, synaptic strength or connectivity with adjacent neurons and long-range cortical projections. The M1 and M3 subunits seem to have a strong influence on neuronal sensitivity because the optimal spatial frequency of the neuronal population is decreased and the contrast sensitivity is increased in M1/M3-KO mice (Groleau et al, 2014). …”
Section: Muscarinic Influence On Visual Processing In V1mentioning
confidence: 99%
“…Nicotinic β2 receptors may also be protective with age, as β2 KO mice also exhibit accelerated aging effects of both basal and apical dendritic loss in layer V neurons in ACC and, to a lesser extent, V1 (Konsolaki and Skaliora, 2015). Data also suggest muscarinic receptors contribute to refinement of circuit development in V1 in mice, where genetic knock-out of different muscarinic receptors alters retinotopic map development (Groleau et al, 2014). …”
Section: Acetylcholine In Brain Developmentmentioning
confidence: 99%
“…These M2R expression patterns map closely with geniculocortical parvocellular projections as well as cholinergic terminals, indicating these receptors are poised to regulate incoming color and fine detail sensory information from thalamic nuclei on both excitatory presumed glutamatergic axons, as well as cholinergic afferents from the basal forebrain (Mrzljak et al, 1993, 1996). Genetic KO studies in mice support a key role for both M1-like and M2-like muscarinic receptors in V1 circuit refinement, as these genetic alterations cause disruptions in visual field size (Groleau et al, 2014). …”
Section: Mature Cortexmentioning
confidence: 99%