Impaired gallbladder motility and delayed orocecal transit contribute to pigment gallstone and biliary sludge formation in β -thalassemia major adults

Portincasa, Piero; Moschetta, Antonio; Berardino, Massimo; Ciaula, Agostino Di; Vacca, Michèle; Baldassarre, Giuseppe; Pietrapertosa, Anna; Cammarota, Rosario; Tannoia, N; Palasciano, Giuseppe

doi:10.3748/wjg.v10.i16.2383

Cited by 37 publications

(47 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The small intestinal transit time in response to the test meal was comparable to that observed in previous studies [28,32], while it was 27% more rapid after both almonds.…”

Section: Discussionsupporting

confidence: 73%

“…Gallbladder, gastric motility and orocecal transit time were studied simultaneously [26][27][28][29][30][31][32][33][34]. Time-dependent changes of fasting and postprandial gallbladder volumes (mL) and antral areas (cm 2 ) were measured from frozen sonograms on a portable scanner (Noblus, Hitachi Medical, Tokyo, Japan) equipped with a 3.5 MHz convex transducer.…”

Section: Gallbladder and Gastric Motilitymentioning

confidence: 99%

See 1 more Smart Citation

Distinct Effects of two Almond Cultivars on Agreeability and Gastrointestinal Motility in Healthy Subjects: more than mere Nutraceuticals

Diella

Ciaula

Lorusso

et al. 2018

JGLD

Self Cite

View full text Add to dashboard Cite

Background: Almonds are healthy nutraceuticals, which vary across different cultivars. We compared the composition, agreeability and gastrointestinal effects of two almond cultivars from different areas.Methods: Californian Carmel (CAcv) and local Apulian Filippo Cea (FCcv) cultivars were compared for the chemical composition and sensory evaluation according to visual analogue and semiquantitative scales in 60 volunteers. Gallbladder/gastric motility (ultrasonography) and orocecal transit time (H2-breath test) were studied in another 24 subjects by comparing the effects of a standard liquid test meal with isovolumetric almond test meals (24 g of CAcv or FCcv almonds).Results: Proteins prevailed in CAcv, while FCcv contained more lipids and 10-times more total phenol content than CAcv. For agreeability, CAcv scored higher than FCcv for smell, texture and appearance, although different perceptions existed in lean (scores for smell, taste, texture, appearance higher for CAcv than FCcv), obese (CAcv better than FCcv only for appearance) and elderly subjects (CAcv better than FCcv only for texture). Gallbladder emptying was stronger with FCcv than CAcv. Antral dilatation after ingestion of both cultivars was greater than the dilatation observed after the test meal. Gastric emptying, however, was similar after FCcv, CAcv and the test meal. The orocecal transit time in response to both cultivars was shorter than after the test meal.Conclusions: Differences in composition and effects of FCcv and CAcv cultivars support their potential use as valuable nutraceutical tools, to be confirmed in further clinical studies.

show abstract

“…The small intestinal transit time in response to the test meal was comparable to that observed in previous studies [28,32], while it was 27% more rapid after both almonds.…”

Section: Discussionsupporting

confidence: 73%

Section: Gallbladder and Gastric Motilitymentioning

confidence: 99%

Distinct Effects of two Almond Cultivars on Agreeability and Gastrointestinal Motility in Healthy Subjects: more than mere Nutraceuticals

Diella

Ciaula

Lorusso

et al. 2018

JGLD

Self Cite

View full text Add to dashboard Cite

show abstract

“…Cholelithiasis may be diagnosed incidentally or in the form of silent stones via ultrasound, however sometimes it may be associated with cholecystitis and cholangitis [3] . About 50-70% of the cholelithiasis cases are asymptomatic and their conversion to symptomatic cases is very low accounting for 10-25% [4] .…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Management of Cholelithiasis in Population of Rajasthan: A Clinical Study

Sarda¹

2018

jmscr

View full text Add to dashboard Cite

“…The tests based on cardiovascular reflexes include Beat-to-beat heart rate variation (DB), heart rate changes after standing (LS), heart rate response to Valsalva maneuver (Vs), heart rate changes induced by cough (cough test, CT), systolic blood pressure response to upright position (PH) [11,6,[12][13][14], (Table 2). All tests are usually performed with portable computerized systems that are used for step-by-step performance of several cardiovascular tests for autonomic neuropathy.…”

Section: Screening Tests For Autonomic Dysfunctionmentioning

confidence: 99%

Links between Autonomic Dysfunction and Metabolic Syndrome

Giampetruzzi¹,

Garruti²

2016

J Metabolic Synd

View full text Add to dashboard Cite

The autonomic nervous system (ANS) plays a key role in the control of a number of vital functions including cardiovascular, endocrine/neurovascular, gastrointestinal, genitourinary, pupil and thermoregulatory functions. Its abnormalities have been associated with early mortality, sudden death, silent myocardial infarction, gastrointestinal diseases.The manifestation of the ANS dysfunction in several human diseases is underestimated. Evidences exist on the important role of ANS dysfunctions in different clinically relevant conditions, including diabetes mellitus, chronic functional constipation, scleroderma, thalassemia major.Beside the classical evaluation in patients with diabetes mellitus, little is known about the effects of metabolic factors on ANS dysfunction. The metabolic syndrome (MetS) includes a cluster of frequent abnormalities (impaired fasting glycaemia, dyslipidemia, arterial hypertension and increased visceral adiposity) predisposing to the atherosclerotic changes and increased cardiovascular mortality. Early signs of autonomic dysfunction are often found in subjects with MetS even in the absence of diabetes. Epidemiological studies demonstrated that diabetics display a cardiovascular risk which is twice that of sex-and age-matched non-diabetic population. Manifestations of such a high cardiovascular risk of subjects with DM are the frequent silent myocardial infarctions (MI)s of diabetics which are often due to impaired cardiovascular autonomic function. Only recently major attention has been given to the interactions between impaired glucose tolerance (IGT) and cardiovascular autonomic dysfunctions. When increased waist circumference (one of the features of the MetS) and IGT are both present, cardiovascular autonomic dysfunction also occurs. Some adipokines (e.g. adiponectin) seem to play a role in cardiovascular risk and autonomic dysfunction. This review will therefore focus on some subtle aspects linking ANS dysfunction and MetS.

show abstract

Impaired gallbladder motility and delayed orocecal transit contribute to pigment gallstone and biliary sludge formation in β -thalassemia major adults

Cited by 37 publications

References 58 publications

Distinct Effects of two Almond Cultivars on Agreeability and Gastrointestinal Motility in Healthy Subjects: more than mere Nutraceuticals

Distinct Effects of two Almond Cultivars on Agreeability and Gastrointestinal Motility in Healthy Subjects: more than mere Nutraceuticals

Prevalence and Management of Cholelithiasis in Population of Rajasthan: A Clinical Study

Links between Autonomic Dysfunction and Metabolic Syndrome

Contact Info

Product

Resources

About