Impaired glucose tolerance in rat islet isograft recipients after cytomegalovirus infection

Smelt, Maaike J.; Haan, de Bart; Faas, Marijke M.; Haan, Aalzen de; Vos, de Paul

doi:10.1111/tid.12041

Cited by 1 publication

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Historically, studies elucidating the link between viruses and hyperglycemia have focused on the role of viruses in inducing or exacerbating diabetes. These studies done both in vitro and in vivo in small animal models have utilized numerous viral pathogens, including herpes viruses ( 119 ), encephalomyocarditis virus (EMCV) ( 120 , 121 ), coxsackievirus B4 ( 122 ), and reoviruses ( 123 ). Infection by the viruses highlighted in these studies was shown to inflict cellular damage on beta cells, leading to hypoinsulinemia, and consequently causing hyperglycemia.…”

Section: Impact Of Hyperglycemia On Viral Immunitymentioning

confidence: 99%

Metabolic syndrome and aberrant immune responses to viral infection and vaccination: Insights from small animal models

et al. 2022

View full text Add to dashboard Cite

This review outlines the propensity for metabolic syndrome (MetS) to induce elevated disease severity, higher mortality rates post-infection, and poor vaccination outcomes for viral pathogens. MetS is a cluster of conditions including high blood glucose, an increase in circulating low-density lipoproteins and triglycerides, abdominal obesity, and elevated blood pressure which often overlap in their occurrence. MetS diagnoses are on the rise, as reported cases have increased by greater than 35% since 1988, resulting in one-third of United States adults currently diagnosed as MetS patients. In the aftermath of the 2009 H1N1 pandemic, a link between MetS and disease severity was established. Since then, numerous studies have been conducted to illuminate the impact of MetS on enhancing virally induced morbidity and dysregulation of the host immune response. These correlative studies have emphasized the need for elucidating the mechanisms by which these alterations occur, and animal studies conducted as early as the 1940s have linked the conditions associated with MetS with enhanced viral disease severity and poor vaccine outcomes. In this review, we provide an overview of the importance of considering overall metabolic health in terms of cholesterolemia, glycemia, triglyceridemia, insulin and other metabolic molecules, along with blood pressure levels and obesity when studying the impact of metabolism-related malignancies on immune function. We highlight the novel insights that small animal models have provided for MetS-associated immune dysfunction following viral infection. Such animal models of aberrant metabolism have paved the way for our current understanding of MetS and its impact on viral disease severity, dysregulated immune responses to viral pathogens, poor vaccination outcomes, and contributions to the emergence of viral variants.

show abstract

Section: Impact Of Hyperglycemia On Viral Immunitymentioning

confidence: 99%

Metabolic syndrome and aberrant immune responses to viral infection and vaccination: Insights from small animal models

et al. 2022

View full text Add to dashboard Cite

show abstract

Impaired glucose tolerance in rat islet isograft recipients after cytomegalovirus infection

Abstract: Impaired glucose tolerance in rat islet isograft recipients after cytomegalovirus infection Smelt, M.J.; de Haan, Bart; Faas, M.M.; de Haan, A.; de Vos, P.

Cited by 1 publication

References 10 publications

Metabolic syndrome and aberrant immune responses to viral infection and vaccination: Insights from small animal models

Metabolic syndrome and aberrant immune responses to viral infection and vaccination: Insights from small animal models

Contact Info

Product

Resources

About