Impaired Glucose Tolerance in Sleep Disorders

Objective To determine whether obstructive sleep apnea mediates the relationship between posttraumatic stress disorder (PTSD) and psychosomatic and somatic disorders and its implications for self-rated health (SRH) among Iraqi immigrants in the United States. Methods A random sample of immigrants who had left Iraq before the 1991 Gulf War (n = 145) or after (n = 205) and are residing in metropolitan Detroit responded to a structured interview covering questions on sociodemographics, premigration trauma, SRH, physician-diagnosed and -treated obstructive sleep apnea, somatic disorders, and psychosomatic disorders. Structural equation modeling was used to evaluate the relationship between premigration trauma scores and health, as well as to explore mediating pathways between PTSD, obstructive sleep apnea, and health. Results The prevalence of obstructive sleep apnea among post-Gulf War immigrants (30.2%) was significantly higher than among pre-Gulf War immigrants (0.7%; p < .001). Premigration trauma scores were positively associated with depression and PTSD. Structural equation modeling supported a model in which obstructive sleep apnea mediated the relationship between PTSD and psychosomatic and somatic disorders. Premigration trauma also related directly to SRH. Conclusions Part of the PTSD-associated adverse health effects observed in Iraqi immigrants is mediated by obstructive sleep apnea. Because sleep apnea in the current study is based on medical history and current treatment, there is a need for future confirmatory polysomnographic studies.

show abstract

“…As reported by others as well, obstructive sleep apnea was predictive of somatic disorders in our model (40–42). …”

Section: Discussionsupporting

confidence: 87%

Obstructive Sleep Apnea, Posttraumatic Stress Disorder, and Health in Immigrants

Arnetz

Templin

Saudi

et al. 2012

Psychosomatic Medicine

View full text Add to dashboard Cite

show abstract

“…Keckels et al found no association between insomnia and impaired glucose metabolism. However, the mean TST in the insomnia group was greater than 5h, and no sub-group analysis was performed to compare TST below and above 5h 26 . In fact, an objective sleep duration of less than 5 h is necessary to increase the risk of diabetes 8,27 .…”

Section: Discussionmentioning

confidence: 99%

Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia

D’Aurea¹,

Poyares²,

Piovezan³

et al. 2015

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Objective To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity.Method A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters.Results The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time.Conclusion Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype.

show abstract

“…In the current study, both short and long sleep durations may contribute to poor self-rated health by increasing fatigue. 46 Previous studies report that both short and long sleep duration are related to a number of adverse physiological changes, including impaired glucose tolerance, 47 inflammation, 48 and high uric acid levels, 49 which increase the risk of chronic diseases such as diabetes, obesity, and hypertension. 17 Conversely, short and long sleep duration could be a result of poor self-rated health.…”

Section: Discussionmentioning

confidence: 99%

The Association between Sleep Duration and Self-Rated Health in the Korean General Population

Kim

Cho

et al. 2013

Journal of Clinical Sleep Medicine

View full text Add to dashboard Cite

Study Objectives: Sleep duration is recognized as one of the most common issues in modern society. Self-rated health is a commonly used subjective health measure based on a single question asking individuals to rate their general health on a four-or fi ve-point scale. However, few studies have examined the relationship between sleep duration and self-rated health. Here, we examined the association between sleep duration and poor self-rated health, using a large representative sample of the general Korean adult population. Design: We conducted a cross-sectional study of 15,252 participants in the Korea National Health and Nutrition Examination Survey IV (2007)(2008)(2009)) who were aged 19 years and older. Sleep duration was categorized as ≤ 5, 6, 7, 8, or ≥ 9 hours. The main outcome of interest was poor self-rated health (n = 3,705, 19.7%). Multiple logistic regression analysis was performed to examine the association between sleep duration and self-rated health. Results: We found both short (≤ 5 h) and long (≥ 9 h) sleep duration to be associated with poor self-rated health independent of sociodemographic, health risk, and health status variables. Compared with 7-h sleep duration, the multivariate odds of poor self-rated health were 1.358 times higher (95% CI 1.167-1.580) with short sleep duration and 1.322 times higher (95% CI 1.091-1.601) with long sleep duration. This association persisted in subgroup analyses of gender, body mass index, and age by gender. Conclusions:In a large representative sample of the Korean general adult population, compared with sleep duration of 7 hours, we found a positive association between short and long sleep duration and poor self-rated health in Korean adults. Furthermore, the association between sleep duration and poor self-rated health was consistently present in subgroups divided by gender, age, and BMI. Keywords: Sleep, sleep duration, self-rated health, gender, age, body mass index (BMI), KNHANES Citation: Kim JH; Kim KR; Cho KH; Yoo KB; Kwon JA; Park EC. The association between sleep duration and self-rated health in the Korean general population.

show abstract

Impaired Glucose Tolerance in Sleep Disorders

Cited by 62 publications

References 33 publications

Obstructive Sleep Apnea, Posttraumatic Stress Disorder, and Health in Immigrants

Obstructive Sleep Apnea, Posttraumatic Stress Disorder, and Health in Immigrants

Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia

The Association between Sleep Duration and Self-Rated Health in the Korean General Population

Contact Info

Product

Resources

About